Precondition of right frontal region with anodal tDCS can restore the fear memory impairment induced by ACPA in male mice

Manteghi, Fariborz; Nasehi, Mohammad; Zarrindast, Mohammad‐Reza

doi:10.17179/excli2016-693

Cited by 6 publications

(2 citation statements)

References 62 publications

(65 reference statements)

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“…The available data was inadequate to perform a meta-analysis on several effects. Among the animal studies, there was only one article reported latency to freezing concerning the effect of anodal tDCS on long-term retention of contextual fear and cued fear (Manteghi et al, 2017). Additionally, there was only one article investigating the effect of cathodal tDCS on long-term fear retention (Duran et al, 2022).…”

Section: Resultsmentioning

confidence: 99%

The Effect of Transcranial Direct Current and Magnetic Stimulation on Fear Extinction and Return of Fear: A meta-analysis and Systematic Review

Lei,

Lai,

Lee

et al. 2023

Preprint

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Anxiety and fear-related disorders are among the most prevalent mental illnesses. Non-invasive brain stimulation methods such as transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) have been employed to modulate anxiety and fear-related symptoms, but their therapeutic effects remain inconclusive. Pavlovian conditioning and extinction are experimental analogues of exposure therapy that investigate the neural mechanisms of fear extinction and return of fear. We conducted a meta-analysis and qualitative review on the effects of tDCS and TMS on fear extinction and return of fear in non-primate animals and humans. Results show that both anodal and cathodal tDCS over the prefrontal cortex inhibit short-term contextual and cued fear retrieval in animal models. In human studies, anodal tDCS over the medial/ventromedial prefrontal cortex enhances fear extinction, whereas TMS over the dorsolateral/ventromedial prefrontal cortex inhibits return of fear. Our findings suggest the optimal non-invasive brain stimulation protocols for threat extinction in humans.

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Section: Resultsmentioning

confidence: 99%

The Effect of Transcranial Direct Current and Magnetic Stimulation on Fear Extinction and Return of Fear: A meta-analysis and Systematic Review

Lei,

Lai,

Lee

et al. 2023

Preprint

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“…However, it is important to note that the effectiveness of device-based techniques in reducing fear may vary. Some research has shown that the application of a-tDCS did not significantly reduce feelings of fear in patients or animals ( Manteghi et al, 2017 ; Wout et al, 2017 ). These conflicting findings could be attributed to differences in brain targets and stimulation frequencies used in the studies.…”

Section: Introductionmentioning

confidence: 99%

Enhancing emotion regulation: investigating the efficacy of transcutaneous electrical acupoint stimulation at PC6 in reducing fear of heights

Cong,

Yu,

Huang

et al. 2024

Front. Psychol.

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This study investigated the impact of transcutaneous electrical acupoint stimulation (TEAS) at Neiguan acupoint (PC6) on the physiological and behavioral responses of participants exposed in virtual height. 40 participants were included in the study and were randomly assigned to either a control group or an intervention group. Participants had an immersive experience with a VR interactive platform that provided somatosensory interaction in height stimulation scenes. Psychological scores, behavioral and cognitive performance, and physiological responses were recorded and analyzed. The results indicated that the intervention group had significantly lower fear scores compared to the control group. Analysis of heart rate variability revealed that the intervention group exhibited improved heart rate variability, indicating enhanced cardiovascular function and emotion regulation. The behavioral and cognitive results demonstrated that the intervention group exhibited higher left eye openness, faster reaction times, and greater movement distance, suggesting enhanced attentional focus, cognitive processing, and reduced avoidance behaviors. These findings suggest that TEAS at PC6 can effectively reduce fear and improve the regulation of physiological and behavioral responses to negative emotional stimuli.

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Memory and Cognition-Related Neuroplasticity Enhancement by Transcranial Direct Current Stimulation in Rodents: A Systematic Review

2020

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Brain stimulation techniques, including transcranial direct current stimulation (tDCS), were identified as promising therapeutic tools to modulate synaptic plasticity abnormalities and minimize memory and learning deficits in many neuropsychiatric diseases. Here, we revised the effect of tDCS on the modulation of neuroplasticity and cognition in several animal disease models of brain diseases affecting plasticity and cognition. Studies included in this review were searched following the terms (“transcranial direct current stimulation”) AND (mice OR mouse OR animal) and according to the PRISMA statement requirements. Overall, the studies collected suggest that tDCS was able to modulate brain plasticity due to synaptic modifications within the stimulated area. Changes in plasticity-related mechanisms were achieved through induction of long-term potentiation (LTP) and upregulation of neuroplasticity-related proteins, such as c-fos, brain-derived neurotrophic factor (BDNF), or N-methyl-D-aspartate receptors (NMDARs). Taken into account all revised studies, tDCS is a safe, easy, and noninvasive brain stimulation technique, therapeutically reliable, and with promising potential to promote cognitive enhancement and neuroplasticity. Since the use of tDCS has increased as a novel therapeutic approach in humans, animal studies are important to better understand its mechanisms as well as to help improve the stimulation protocols and their potential role in different neuropathologies.

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Precondition of right frontal region with anodal tDCS can restore the fear memory impairment induced by ACPA in male mice

Cited by 6 publications

References 62 publications

The Effect of Transcranial Direct Current and Magnetic Stimulation on Fear Extinction and Return of Fear: A meta-analysis and Systematic Review

The Effect of Transcranial Direct Current and Magnetic Stimulation on Fear Extinction and Return of Fear: A meta-analysis and Systematic Review

Enhancing emotion regulation: investigating the efficacy of transcutaneous electrical acupoint stimulation at PC6 in reducing fear of heights

Memory and Cognition-Related Neuroplasticity Enhancement by Transcranial Direct Current Stimulation in Rodents: A Systematic Review

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