Preconceptual paternal environmental stimulation alters behavioural phenotypes and adaptive responses intergenerationally in Swiss mice

Hoffmann, Lucas Barbosa; Rae, Mariana; Marianno, Priscila; Pang, Terence Y; Hannan, Anthony J; Camarini, Rosana

doi:10.1016/j.physbeh.2020.112968

Cited by 7 publications

(18 citation statements)

References 63 publications

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“…However, unexpectedly, their F1 male offspring showed impaired performance on the same tests and less attractiveness to females than controls. However, when F1 males of prereproductive EE fathers were exposed to a short period of EE during adulthood, the deficits in behavioral outcomes were no longer observed 38 . The findings indicate that exposing fathers to an EE paradigm may have negative impacts on male offspring, suggesting a mismatch scenario where a previously advantageous trait becomes maladaptive due to environmental changes.…”

Section: Fathers Do Count: Role Of Paternal Enrichmentmentioning

confidence: 84%

“…It is consistently reported that EE induces animal bodyweight loss 37–39 . In a metabolic and physiological approach, pregestational (from postnatal week 12 to postnatal week 16) EE‐induced female weight loss correlated with decreases in white adipose tissue and decreased glucose, insulin, leptin, cholesterol, and triglyceride plasma levels, measured over the time to mating 40 .…”

Section: Pregestational Enriched Environmentmentioning

confidence: 90%

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Parental enriched environment: A look through key temporary windows

Mir

Renard

Rivarola

2023

J Neuroendocrinology

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Environmental enrichment is a widely used experimental manipulation that physically, cognitively and socially stimulates individuals. It has a great variety of long‐term effects at neuroanatomical, neurochemical, and behavioral level; however, the influence of parental environmental enrichment during gestation and pregestation on the development of the offspring and on the mother's behavior has been poorly explored. This article presents a review of the literature from the year 2000 about the effects of maternal and paternal environmental enrichment on the behavioral, endocrine, and neural systems of offspring and parents. Relevant research terms were searched for on the biomedical databases, PubMed, Medline, ScienceDirect, and Google Scholar. The data suggest that paternal/maternal environmental enrichment can profoundly affect the developmental trajectories of offspring through putative epigenetic mechanisms. Environmental enrichment presents as a promising therapeutic tool for human health interventions, especially to counteract the deleterious effects of impoverished and adverse growing conditions.

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Section: Fathers Do Count: Role Of Paternal Enrichmentmentioning

confidence: 84%

Section: Pregestational Enriched Environmentmentioning

confidence: 90%

Parental enriched environment: A look through key temporary windows

Mir

Renard

Rivarola

2023

J Neuroendocrinology

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“…the protocol was adapted from Hoffmann et al, 2020; Mitra and Sapolsky, 2012. Using a 3-chamber interaction test, a fertile female (assessed daily before the test by vaginal smear) explored the apparatus for 10 min.…”

Section: Methodsmentioning

confidence: 99%

“…Mate-choice test: the protocol was adapted from Hoffmann et al, 2020;Mitra and Sapolsky, 2012. Using a 3-chamber interaction test, a fertile female (assessed daily before the test by vaginal smear) explored the apparatus for 10 min. Then, one male from each experimental group was put inside a small cage on each side of the apparatus, and the female explored the apparatus again for 10 min, during which the time she spent interacting with each male mouse was measured.…”

Section: Behavioural Experimentsmentioning

confidence: 99%

“…Paternal environment preconception can affect offspring behaviour via intergenerational epigenetic inheritance (Chan et al, 2020; Crews et al, 2007; Gapp et al, 2014b; Hoffmann et al, 2020; Zhang et al, 2018). Various animal models have been developed to study this phenomenon, with effects described most commonly in the offspring of these animals, but also up to the third generation (van Steenwyk et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Increased paternal corticosterone exposure preconception shifts offspring social behaviours and expression of urinary pheromones

Hoffmann

McVicar

Hannan

et al. 2022

Preprint

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Studies have shown that paternal stress prior to conception can influence the innate behaviours of their offspring. The evolutionary benefits of such intergenerational adaptations continue to be speculated upon. Our group previously showed that glucocorticoid treatment of adult male breeders prior to conception leads to increased anxiety-related behaviours in male offspring. Here, we aimed to understand the transgenerational effects of paternal stress exposure on the social behaviour of progeny and its potential influence on adaptive fitness. We assessed social parameters including social reward, male attractiveness and social dominance, in the offspring (F1) and grand-offspring (F2). We report that paternal corticosterone-treatment was associated with increased display of subordination towards other male mice. Those mice were unexpectedly more attractive to female mice while expressing reduced levels of the key rodent pheromone Darcin, contrary to its conventional purpose. No overt differences of the prefrontal cortex transcriptome were found in F1 offspring, implying that peripheral mechanisms are likely contributing to the phenotypic differences. Interestingly, no phenotypic differences were observed in the F2 grand-offspring. Overall, our findings highlight the contribution of moderate paternal stress to an intergenerational adaptive response, informing future studies of adaptive fitness in rodents, humans and other species.

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