Preconceptual caffeine exposure increases glucose utilization and accelerates development in the preimplantation rat embryo

Loupis, Anne; Ryan, John P.; Waite, Kathleen; Pollard, Irina

doi:10.1002/(sici)1520-6661(199611/12)5:6<321::aid-mfm6>3.3.co;2-j

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two rat studies, both originating from this author's concern and interests, have directly addressed this question. The first demonstrated that caffeine administered to female rats prior to fertilization affected the rate of development of a proportion of the subsequent preimplantation rat embryos (Loupis et al, 1996). The second study investigated whether such a caffeine-induced developmental change is sustained to the extent of affecting the progeny after birth .…”

Section: The Preconceptional Period: Female-mediated Effectsmentioning

confidence: 99%

Substance Abuse and Parenthood: Biological Mechanisms-Bioethical Challenges

Pollard

2000

Women & Health

Self Cite

View full text Add to dashboard Cite

This review catalogues the long-term health effects of parental recreational drug abuse on the fetus and the subsequent well-being of the child. It is hard to conceive that parents would knowingly harm the health of their children, yet toxic effects resulting from ignorance, addiction or any of a number of socioeconomic factors are still responsible for handicapping countless potentially healthy offspring. The negative effects of female recreational drug and alcohol abuse during pregnancy are well documented, but exposure prior to conception and male-mediated effects are less well publicized. Abnormalities in the sperm are prevalent among men who consume recreational drugs, and birth defects are more often linked with paternal than with maternal DNA damage. This review is divided into three parts. Part I describes the biology and potential mechanisms of adverse alterations in reproductive potential, Part II explores the socioeconomic determinants of substance use, and raises the question of poverty. Drug-induced disability is not evenly distributed among the population as there are ethnic and socioeconomic disparities of infant mortality, childhood morbidity and reproductive dysfunction. Part III describes the author's conclusion that fundamental social change is needed to protect future children without threatening parents' basic freedom, and real change requires new beliefs and prioritics that must evolve from the ground up. An ecological model of care concentrating on health issues is described. Such an ecological model of care is in tune with the fundamental principles of bioscience ethics and emphasises that high quality education, health and good preconceptional/prenatal care are essentials in the search for greater equity in standard of living across a population.

show abstract

Section: The Preconceptional Period: Female-mediated Effectsmentioning

confidence: 99%