2023
DOI: 10.1172/jci167624
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Preconception paternal ethanol exposures induce alcohol-related craniofacial growth deficiencies in fetal offspring

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Cited by 10 publications
(3 citation statements)
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“…Alcohol is a potent teratogen and the most common cause of birth defects, with an estimated 6-17 children per 1000 live births diagnosed with some degree of fetal alcohol spectrum disorder (May et al, 2017;Popova et al, 2017). Although well established that maternal alcohol use during pregnancy causes birth defects, our group recently reported teratogenic outcomes resulting from chronic preconception paternal alcohol exposures, including defects in craniofacial growth consistent with alcohol-related birth defects observed in maternal models of exposure (Thomas et al, 2022(Thomas et al, , 2023. Our studies demonstrate that male drinking is a plausible yet completely unexamined factor in the development of alcohol-related craniofacial abnormalities.…”
Section: Paternally Programmed Congenital Malformations Do They Exist?mentioning
confidence: 74%
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“…Alcohol is a potent teratogen and the most common cause of birth defects, with an estimated 6-17 children per 1000 live births diagnosed with some degree of fetal alcohol spectrum disorder (May et al, 2017;Popova et al, 2017). Although well established that maternal alcohol use during pregnancy causes birth defects, our group recently reported teratogenic outcomes resulting from chronic preconception paternal alcohol exposures, including defects in craniofacial growth consistent with alcohol-related birth defects observed in maternal models of exposure (Thomas et al, 2022(Thomas et al, , 2023. Our studies demonstrate that male drinking is a plausible yet completely unexamined factor in the development of alcohol-related craniofacial abnormalities.…”
Section: Paternally Programmed Congenital Malformations Do They Exist?mentioning
confidence: 74%
“…This challenge largely stems from our inability to measure dimensions of sperm quality beyond morphology, motility, and DNA strand breaks. For example, our research has identified significant impacts of preconception paternal alcohol exposure on offspring craniofacial development, fetoplacental growth, and longer‐term impacts on the metabolic health of the adult offspring, all of which occur without any overt changes in sperm counts, morphology, or fertility (Y. Bedi et al, 2019; R. C. Chang et al, 2017; R. C. Chang, Thomas, et al, 2019; R. C. Chang, Wang, et al, 2019; Thomas et al, 2022, 2023). Similarly, males maintained on a diet deficient in folic acid have normal testes morphology and sperm counts yet were able to transmit adverse outcomes to their offspring via epigenetic mechanisms (Lambrot et al, 2013; Lismer et al, 2021).…”
Section: Paternal Exposures and Teratogenesis: Current Challenges And...mentioning
confidence: 99%
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