Preconception origins of asthma, allergies and lung function: The influence of previous generations on the respiratory health of our children

Svanes, Cecilie; Holloway, John W.; Krauss‐Etschmann, Susanne

doi:10.1111/joim.13611

Cited by 10 publications

(3 citation statements)

References 135 publications

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“…It is evident that children born to mothers that smoked during pregnancy have several genomic loci with altered methylation patterns, but whether this can be inherited in subsequent generations remains unclear. Smoking in teenage boys has also been proposed to impact on sperm condition and alter the risk of producing allergic offspring 62 . With cigarette smoking having come into and out of the human population and with rates of vaping now rapidly increasing, there are at least opportunities to address the impact of smoking or inhaled tobacco on heritable nongenetic traits, but these studies will have to be well controlled to provide meaningful results.…”

Section: What Role Do You See For Nongenetic But Heritable Traits (Ie...mentioning

confidence: 99%

A conversation on allergy: recognizing the past and looking to the future

Melén,

Lambrecht,

Lloyd

et al. 2023

Immunol Cell Biol

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Allergy is an ever‐evolving group of disorders, which includes asthma, atopic dermatitis, rhinitis and food allergies and that currently affects over 1 billion people worldwide. This group of disorders has exploded in incidence since around the start of the 20th century, implying that genetics is not solely responsible for its development but that environmental factors have an important role. Here, Fabio Luciani and Jonathan Coquet, in their role as editors at Immunology & Cell Biology, asked nine prominent researchers in the field of allergy to define the term ‘allergy’, discuss the role of genetics and the environment, nominate the most important discoveries of the past decade and describe the best strategies to combat allergy at the population level going forward.

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Section: What Role Do You See For Nongenetic But Heritable Traits (Ie...mentioning

confidence: 99%

A conversation on allergy: recognizing the past and looking to the future

Melén,

Lambrecht,

Lloyd

et al. 2023

Immunol Cell Biol

View full text Add to dashboard Cite

show abstract

“…To what extent improving FEV 1 will improve non-respiratory outcomes is not known, but clearly a low FEV 1 should always be taken very seriously. Also importantly, there are transgenerational effects of adverse exposures (reviewed in SVANES et al [18]). If the child with a low FEV 1 becomes a parent, his/her children will have impaired spirometry; approximately 30% of offspring spirometry is determined by parental spirometry [3].…”

Section: Introductionmentioning

confidence: 99%

“…Also importantly, there are transgenerational effects of adverse exposures (reviewed in S vanes et al [ 18 ]). If the child with a low FEV 1 becomes a parent, his/her children will have impaired spirometry; approximately 30% of offspring spirometry is determined by parental spirometry [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Social determinants of respiratory health from birth: still of concern in the 21st century?

Bush,

Byrnes,

Chan

et al. 2024

Eur Respir Rev

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Respiratory symptoms are ubiquitous in children and, even though they may be the harbinger of poor long-term outcomes, are often trivialised. Adverse exposures pre-conception, antenatally and in early childhood have lifetime impacts on respiratory health. For the most part, lung function tracks from the pre-school years at least into late middle age, and airflow obstruction is associated not merely with poor respiratory outcomes but also early all-cause morbidity and mortality. Much would be preventable if social determinants of adverse outcomes were to be addressed. This review presents the perspectives of paediatricians from many different contexts, both high and low income, including Europe, the Americas, Australasia, India, Africa and China. It should be noted that there are islands of poverty within even the highest income settings and, conversely, opulent areas in even the most deprived countries. The heaviest burden of any adverse effects falls on those of the lowest socioeconomic status. Themes include passive exposure to tobacco smoke and indoor and outdoor pollution, across the entire developmental course, and lack of access even to simple affordable medications, let alone the new biologicals. Commonly, disease outcomes are worse in resource-poor areas. Both within and between countries there are avoidable gross disparities in outcomes. Climate change is also bearing down hardest on the poorest children. This review highlights the need for vigorous advocacy for children to improve lifelong health. It also highlights that there are ongoing culturally sensitive interventions to address social determinants of disease which are already benefiting children.

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Study on the mechanism of Cutaneous and Respiratory Comorbidities with Chinese and Western medicine theories and research

Liu,

Xie,

Yan

et al. 2024

Advanced Chinese Medicine

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In the realms of traditional Chinese medicine and Western medicine research, the skin and lungs are recognized for their integral roles in both the physiological functions and pathological mechanisms affecting the human body. These organs are not only complementary and coordinated in their physiological functions but also interact pathologically, providing feedback and influencing each other. The etiology of immune‐mediated skin diseases is multifaceted, involving numerous factors beyond mere skin characteristics, often including multisystem diseases. Cutaneous and Respiratory Comorbidities denote the concurrent presence of skin and lung diseases, sharing a common pathogenic mechanism. Although research on Cutaneous and Respiratory Comorbidities has received increasing attention, the foundational theories and the specifics of related diseases remain unclear. This paper aims to elucidate the theoretical basis of both traditional Chinese and Western medicine concerning immune‐mediated Cutaneous and Respiratory Comorbidities, thereby laying a groundwork for the early detection and integrated treatment of these diseases.

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Preconception origins of asthma, allergies and lung function: The influence of previous generations on the respiratory health of our children

Abstract: Svanes C, Holloway JW, Krauss-Etschmann S. Preconception origins of asthma, allergies and lung function: The influence of previous generations on the respiratory health of our children.

Cited by 10 publications

References 135 publications

A conversation on allergy: recognizing the past and looking to the future

A conversation on allergy: recognizing the past and looking to the future

Social determinants of respiratory health from birth: still of concern in the 21st century?

Study on the mechanism of Cutaneous and Respiratory Comorbidities with Chinese and Western medicine theories and research

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