Preconception Folate and Vitamin B6 Status and Clinical Spontaneous Abortion in Chinese Women

Ronnenberg, Alayne G.; Goldman, Marlene B.; Chen, Dafang; Aitken, Iain; Willett, Walter C.; Selhub, Jacob; Xu, Xiping

doi:10.1097/00006250-200207000-00017

Cited by 15 publications

(19 citation statements)

References 21 publications

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“…Our findings that moderate folate levels in early pregnancy are associated with higher birth weight regardless of race/ethnicity are consistent with previous studies, [14][15][16][17][18][19][20][21][22][23][24]50 although an equally large number of studies from Europe, Asia and the US [25][26][27][28][29][30][31] have not confirmed these associations. Reasons for discordant findings are unclear.…”

Section: Discussionsupporting

confidence: 88%

“…13 In humans, evidence of associations between maternal folate concentrations and fetal growth is conflicting, as high levels have been linked to both low and high birth weight, [14][15][16][17][18][19][20][21][22][23][24] while other studies found no associations. [25][26][27][28][29][30][31] Extremes of the birth weight distribution have been associated with a wide range of childhood and adultonset chronic diseases and conditions including obesity, impaired glucose tolerance, type 2 diabetes, coronary artery disease, congestive heart failure and some cancers. [32][33][34][35][36] Periconceptional and perinatal exposure to FA supplements has also been linked to wheezing in mice 37 and humans, 38 as well as childhood asthma.…”

Section: Introductionmentioning

confidence: 99%

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Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort

et al. 2014

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort

et al. 2014

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“…These observations are partly confirmed by the Dutch Generation R study, showing that the degree of adherence to the Mediterranean diet is positively associated with maternal serum levels of folic acid and vitamin B12 and that, on the other hand, a poor diet correlates with increased risk of hypertension in the gestational period [99]. Some observations also support the efficacy of supplementation with multivitamins and multiminerals [100,101]. …”

Section: Focus On Conditions Associated With Nutrient Deficienciesmentioning

confidence: 73%

Maternal Diet and Nutrient Requirements in Pregnancy and Breastfeeding. An Italian Consensus Document

Marangoni¹,

et al. 2016

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The importance of lifestyle and dietary habits during pregnancy and breastfeeding, for health of mothers and their offspring, is widely supported by the most recent scientific literature. The consumption of a varied and balanced diet from the preconceptional period is essential to ensure both maternal well-being and pregnancy outcomes. However, the risk of inadequate intakes of specific micronutrients in pregnancy and lactation is high even in the most industrialized countries. This particularly applies to docosahexaenoic acid (DHA), iron, iodine, calcium, folic acid, and vitamin D, also in the Italian population. Moreover, the risk of not reaching the adequate nutrient supply is increased for selected groups of women of childbearing age: those following exclusion diets, underweight or overweight/obese, smokers, adolescents, mothers who have had multiple or close pregnancies, and those with previous unfavorable pregnancy outcomes.

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“…In most studies, tHcy has been measured either in the nonpregnant state (retrospectively) or at the time of the event. In two studies in which blood samples were collected before conception, increased tHcy was associated with increased risk of spontaneous abortions and preterm births (205,206 ). The data on the predictive role of increased tHcy during pregnancy and the effect of tHcy-reducing therapy in the prevention of adverse pregnancy outcomes are conflicting (198,(207)(208)(209).…”

Section: Pregnancy Complications and Birth Defectsmentioning

confidence: 99%

“…Increased tHcy is associated with birth defects and pregnancy complications, but it is uncertain whether tHcy-lowering treatment is beneficial in hyperhomocysteinemic women. The results of prospective studies on whether increased tHcy predicts adverse pregnancy outcomes are conflicting (198,(205)(206)(207)(208)(209). Thus, the use of tHcy measurement should be confined to certain high-risk groups.…”

Section: Pregnancy Complications and Birth Defectsmentioning

confidence: 99%

Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion

et al. 2004

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Background: Measurement of plasma total homocysteine has become common as new methods have been introduced. A wide range of disorders are associated with increased concentrations of total homocysteine. The purpose of this review is to provide an international expert opinion on the practical aspects of total homocysteine determinations in clinical practice and in the research setting and on the relevance of total homocysteine measurements as diagnostic or screening tests in several target populations. Methods: Published data available on Medline were used as the basis for the recommendations. Drafts of the recommendations were critically discussed at meetings over a period of 3 years. Outcome: This review is divided into two sections: (a) determination of homocysteine (methods and their performance, sample collection and handling, biological determinants, reference intervals, within-person variability, and methionine loading test); and (b) risk assessment and disease diagnosis (homocystinuria, folate and cobalamin deficiencies, cardiovascular disease, renal failure, psychiatric disorders and cognitive impairment, pregnancy complications and birth defects, and screening of elderly and newborns). Each of these subsections concludes with a separate series of recommendations to assist the clinician and the research scientist in making informed decisions. The review concludes with a list of unresolved questions. © 2004 American Association for Clinical ChemistryIncreased plasma total homocysteine (tHcy) 7 is a sensitive marker of folate and cobalamin (vitamin B 12 ) deficiency (1, 2 ) and an independent risk factor for cardiovascular disease (CVD) (3,4 ). Plasma tHcy concentrations are also related to birth defects (5 ), pregnancy complications (6 ), psychiatric disorders (7 ), and cognitive impairment in the elderly (8 ). The measurement of tHcy in the clinical setting is thus potentially of great importance (9 ).The introduction of tHcy assays in the mid-1980s (10, 11 ) started a new era of research on Hcy. However, it was the advent of immunoassays in the latter half of the 1990s (12, 13 ) that changed tHcy determinations from research tools to widely used clinical chemistry tests. As a result, interest in this field has increased exponentially in both routine diagnostics and research.Although several reviews on tHcy determinations have been published (14 -18 ), few have provided recommendations for their use in clinical practice (19 -23 ). Our aim was to review the practical aspects of tHcy determinations in clinical practice as well as in the research setting and to survey the data on tHcy in diagnostics or as screening tests in several target populations.Ideally, guidelines should be established by a multidisciplinary team including all relevant stakeholders, and the recommendations should be according to evidence-based medicine (24 ). There are not sufficient data in the Hcy field, however, to use such an approach. In particular, -32 (2004) Review 3 data from controlled clinical trials are sparse. Neverth...

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Preconception Folate and Vitamin B6 Status and Clinical Spontaneous Abortion in Chinese Women

Cited by 15 publications

References 21 publications

Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort

Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort

Maternal Diet and Nutrient Requirements in Pregnancy and Breastfeeding. An Italian Consensus Document

Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion

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