Precocious Puberty Resulting from Congenital Hypothalamic Hamartoma: Persistent Darkened Areolae After Birth as the Hallmark of Estrogen Excess

Arisaka, Osamu; Negishi, Masao; Numata, Michio; Hoshi, Megumi; Kanazawa, Sanae; Oyama, Mariko; Nitta, Akihisa; Suzumuara, Hiroshi; Kuribayashi, Takeo; Nakayama, Yuko

doi:10.1177/000992280104000307

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Cited by 3 publications

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“…7 Pigmented stimulated areolae and nipples are hallmarks of estrogen excess. 8 Estrogen receptor is also present in the labia minora, 9 but in the present case, the labia minora failed to grow despite exposure to excess estrogen. This finding indicates that IGF-I is essential for development of the labia minora, and it is of note that maturation of the labia minora is reported to be delayed in Laron syndrome.…”

Section: Discussioncontrasting

confidence: 47%