Precocious Puberty in Internationally Adopted Girls

Teilmann, Grete; Parent, Anne-Simone; Skakkebæk, Niels E.; Bourguignon, Jean-Pierre

doi:10.1007/978-1-59745-499-5_21

Cited by 6 publications

(8 citation statements)

References 88 publications

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“…16 In contrast, in children adopted out of adverse environments such as institutional or foster care, many, though not all studies, 15,19 have documented a higher rate of early pubertal development particularly in girls. 10,17 In a longitudinal study of 276 internationally adopted girls to Denmark, the normal probability curves for breast development and menarche were similar in shape to those of typically developing Danish girls but were displaced 1.3 years earlier for both breast development and menarche. 41 Consequently, 16% entered puberty prior to 8 years of age and approximately the same percentage experienced menarche prior to 11 years of age.…”

Section: Discussionmentioning

confidence: 95%

“…Past studies reporting earlier puberty in girls were conducted in intercountry adoptees placed in Western Europe and the US. 10,17,18 Considering the social and financial requirements that parents must meet to qualify to adopt internationally, these children likely experienced permanent placement in economically stable families within high resource countries. 51 Conversely, our children were placed in foster care during the difficult economic times preceding Romania’s accession to the European Union in 2007 when nutrition or the level of overall family stress, may have been significantly different.…”

Section: Discussionmentioning

confidence: 99%

“…10–12 Many studies have documented catch-up growth over the short term in children placed in more nurturing environments, 10–12 3 longitudinal studies have tracked physical growth through late childhood or adolescence. 13–15 Less is known about how early institutionalization influences pubertal development with reports of delays, 16 accelerations, 10,14,17,18 and null 15,19 effects on various markers of pubertal development in boys and girls.…”

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confidence: 99%

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Caregiving Disruptions Affect Growth and Pubertal Development in Early Adolescence in Institutionalized and Fostered Romanian Children: A Randomized Clinical Trial

Johnson

Tang

Almas

et al. 2018

The Journal of Pediatrics

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Objectives To determine the effects of foster care vs institutional care, as well as disruptions in the caregiving environment on physical development through early adolescence. Study design This was a randomized controlled trial of 114 institutionalized, though otherwise healthy, children from 6 orphanages and 51 never institutionalized control children living in birth families (family care group) in Bucharest, Romania. Children were followed from baseline (21 months, range 5–31) through age 12 years for caregiving disruptions and growth trajectories and through age 14 years for pubertal development. Results Children randomized to the foster care group showed greater rates of growth in height, weight, and body mass index (BMI) through age 12 years than institutionalized group. Tanner development was delayed in institutionalized group boys compared with foster care group and family care group boys at 12 but not 14 years. There were no differences in Tanner development and age of menarche among foster care group, institutionalized group, and family care group girls at ages 12 and 14 years. More disruptions in caregiving between 30 months and 12 years moderated decreases in growth rates of height in foster care group and weight in foster care group and institutionalized group across age. institutionalized group boys with ≥2 disruptions showed lower Tanner scores at age 12 vs institutionalized group and foster care group boys with <2 disruptions. foster care group girls with ≥2 disruptions had higher Tanner scores at age 14 vs foster care group girls with <2 disruptions. Age of menarche was not affected by caregiving disruptions. Conclusions For children who experienced early institutionalization, stable placement within family care is essential to ensuring the best outcomes for physical developmental. Trial registration clinicaltrials.gov: NCT00747396.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Caregiving Disruptions Affect Growth and Pubertal Development in Early Adolescence in Institutionalized and Fostered Romanian Children: A Randomized Clinical Trial

Johnson

Tang

Almas

et al. 2018

The Journal of Pediatrics

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“…The female preponderance implies a factor of central origin, but peripheral signals may be permissive or enhancing. Suggested contributing factors have included low birth weight, perinatal stress, changes in diet and exposure to environmental chemicals with endocrine disrupting effects in the country of origin (11).…”

Section: Issues In Defining Precocitymentioning

confidence: 99%

The use of GnRH agonists in precocious puberty

Mul¹,

Hughes

2008

European Journal of Endocrinology

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In this review several aspects of gonadotrophin releasing hormone agonists (GnRHa) treatment in central precocious puberty (CPP) are highlighed. These include issues of the definition of precocity, assessment of CPP and thelarche variants. Indications for treatment with GnRH agonists are discussed, not only in CPP but also in children with other reasons to suppress central activation, e.g. adopted or developmental retardation. Finally, outcome data are summarized, both on growth and psychosocial parameters.European Journal of Endocrinology 159 S3-S8

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“…Girls that migrate to higher-income countries than girls that remain in lower-income countries or native-born girls from the host country, thereby suggesting that earlier onset of puberty among certain racial/ethnic groups is due to early life changes in nutritional and infectious factors Teilmann et al, 2006). Other studies, among children with varied migration circumstances, report that adopted girls and boys begin puberty earlier than girls and boys who migrate with their families, suggesting that psychosocial stress, in addition to nutrition and infection, is associated with earlier puberty (Bae et al, 2014;Mul et al, 2002;Teilmann et al, 2006;Teilmann et al, 2007). Whether these effects of migration on the first-generation migrants persist into the second and third generation is of particular interest especially among U.S. Hispanic/ Latino youth.…”

mentioning

confidence: 99%

Immigrant generation status and its association with pubertal timing and tempo among Hispanic girls and boys

Houghton

Paniagua-Ávila

Hua

et al. 2023

American J Hum Biol

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PurposeIn the United States, Hispanic‐Latino children reach puberty earlier on average than non‐Hispanic white children. Yet among U.S. Hispanic/Latino children, pubertal timing comparisons between immigrant generations have not been made, hence we examined whether pubertal timing differs by immigrant generational status, independent of BMI and acculturation measures.MethodsCross‐sectional data on 724 boys and 735 girls, aged 10–15 years, from the Hispanic Community Children's Health Study/Study of Latino (SOL) Youth, were used to predict the median ages of thelarche, pubarche, and menarche in girls, and pubarche and voice change in boys, using Weibull survival models, while adjusting for SOL center, BMI, and acculturation.ResultsIn girls, the first generation began thelarche earlier than second and third generations (median age [years] [95% confidence interval]: 7.4 [6.1, 8.8] vs. 8.5 [7.3, 9.7] and 9.1 [7.6, 10.7], respectively), but began menarche later (12.9 [12.0,137] vs. 11.8 [11.0, 12.5] and 11.6 [10.6, 12.6], respectively). Pubertal timing and tempo for boys did not differ by generational status.ConclusionsFirst‐generation U.S. Hispanic/Latino girls had the earliest thelarche, latest menarche and longest pubertal tempo, compared to second and third generations. Factors beyond BMI and acculturation may account for the differences in pubertal timing by generational status of U.S. Hispanic/Latino girls.

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Precocious Puberty in Internationally Adopted Girls

Cited by 6 publications

References 88 publications

Caregiving Disruptions Affect Growth and Pubertal Development in Early Adolescence in Institutionalized and Fostered Romanian Children: A Randomized Clinical Trial

Caregiving Disruptions Affect Growth and Pubertal Development in Early Adolescence in Institutionalized and Fostered Romanian Children: A Randomized Clinical Trial

The use of GnRH agonists in precocious puberty

Immigrant generation status and its association with pubertal timing and tempo among Hispanic girls and boys

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