Precocious and Exaggerated Seric IgA Production in Children Affected by IDDM

Gasparini, N; Valerio, Giuliana; Argenziano, A.; Salerno, M.; Filippo, Gianpaolo De; Franzese, Adriana; Tenore, Alfred

doi:10.2337/diacare.19.7.779b

Cited by 1 publication

(4 citation statements)

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“…Moreover, prevalence of IgA-D in our case report is higher than previously described by Cerutti et al [ 7 ] by Picarelli et al [ 15 ] in Italy, although in another Italian study regarding children with type 1 diabetes, the prevalence rate of IgA-D was similar [ 10 ]. However, our results are hardly comparable with those of previous studies: study design, age and number of patients, diagnosis criteria of IgA-D, genetic and geographical background can explain the differences across studies; on the other hand, data published have emanated largely from paediatric referral departments rather than general diabetes centres and principally derived from studies designed to investigate association between CD and type 1 diabetes rather than IgA-D.…”

Section: Discussioncontrasting

confidence: 65%

“…Many studies have examined the association between IgA-D and type 1 diabetes mellitus: although a higher prevalence of IgA-D has been reported in screened diabetes clinic populations, frequencies largely differ among reports [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Selective immunoglobulin A deficiency (IgA-D) is the most common primary immunodeficiency disease but its prevalence varies widely within different geographical regions [ 1 , 2 , 3 ]. The association between type 1 diabetes and IgA-D has long been recognized in many populations: in several studies of children and adults with type 1 diabetes, a high prevalence of IgA-D has been found [ 1 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. Although no cases were observed in some studies [ 4 , 11 , 15 ], the prevalence rates of IgA-D in subjects with type 1 diabetes are estimated to be between 0.4% and 5.4% which is more than 10 times the prevalence in the general population.…”

Section: Introductionmentioning

confidence: 99%

“…There are few reports in literature regarding IgA-D in type 1 diabetes mellitus in Italian population [ 7 , 10 , 15 ]; furthermore, data published derived largely from studies designed to investigate the association between CD and diabetes rather than IgA-D and conducted principally in the paediatric age group [ 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Selective Immunoglobulin A Deficiency in Type 1 Diabetes Mellitus: A Prevalence Study in Western Sicily (Italy)

Greco

Maggio

2015

Diabetes Metab J

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BackgroundThe association between type 1 diabetes and immunoglobulin A deficiency (IgA-D) has long been recognized in many populations. The aim of this study was to assess the prevalence of IgA-D in patients with type 1 diabetes mellitus all coming from a defined geographical area and to investigate the clinical features of these subjects.MethodsThe records of 150 consecutive patients with type 1 diabetes mellitus referred in a period of one year were analyzed. A detailed history was obtained for each patient. Information was collected concerning age, gender, time of onset of diabetes, and presence of other autoimmune diseases.ResultsOut of 150 patients with type 1 diabetes, eight (5.3%) had a diagnosis of IgA-D. There were one female and seven male; all these patients were diagnosed by screening: none of them had history of recurrent infections. Autoimmune thyroiditis was coexisting in five patients (62%). Although other associated autoimmune disorders were found in a number of patients, there was no different prevalence rate in IgA deficient patients.ConclusionThis study shows the prevalence of IgA-D in Sicilian patients with type 1 diabetes as 5.3% which is much higher than reported in other Italian studies. Moreover, our data show a high prevalence of IgA-D in male gender and describe thyroiditis as the most frequent autoimmune disease present in these patients. Finally, in our case report, IgA-D diagnosis always followed routine IgA measurement when case finding for celiac disease with no history of recurrent infections in each patient.

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Section: Discussioncontrasting

confidence: 65%