Precocious and accelerated puberty in children with neurofibromatosis type 1: results from a close follow-up of a cohort of 45 patients

Pinheiro, Sara; Maciel, Joana; Cavaco, Daniela; Figueiredo, Ana; Damasio, Ines; Donato, Sara; Passos, João; Simões‐Pereira, Joana

doi:10.1007/s42000-022-00411-9

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…And may increase the risk of high blood pressure, diabetes, obesity, and infertility in adulthood [ 4 ]. Previous studies showed [ 5 – 7 ] that the occurrence of early puberty in children may be related to gender, leptin, daily activity time, etc., but the results of each study are not completely consistent. Therefore, it is necessary to identify the relevant factors that cause precocious puberty in children as early as possible, and prevent its risk factors, so as to avoid the adverse effects of precocious puberty on children.…”

Section: Introductionmentioning

confidence: 99%

Analysis of risk factors of precocious puberty in children

Dong,

Dai,

Dong

et al. 2023

BMC Pediatr

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Background The purpose of this study is to explore the related factors of precocious puberty in children. Methods 1239 children who underwent physical examination in our hospital from January 2020 to December 2022 were analyzed, including 198 precocious children and 1041 normal children. According to the age of 198 precocious children and 1041 normal children, 205 normal children were selected, and the remaining 836 normal children were excluded. They were divided into precocious group and normal group. The general data of the two groups were recorded. Logistic regression was used to analyze the influencing factors of precocious puberty in children. Results There were statistically significant differences (P < 0.05) between the two groups in sex, bone age, daily exercise time, E2, FSH, LH, leptin, mother’s menarche time, living environment, consumption of nutritional supplements, consumption of foods containing pigments and preservatives, consumption of high-protein foods, and sleeping time. The multifactor logistic regression analysis shows that the risk factors of children’s precocious puberty included gender (female), bone age (> 10 years old), and daily exercise time (< 0.9 h), E2 (≥ 66.00pmol/L), FSH (≥ 6.00U/L), LH (≥ 3.50U/L), leptin (≥ 8.00 µ G/L), mother’s menarche time (< 12 years old), living environment (chemical industry zone), consumption of nutritional supplements (often), consumption of high-protein food (often), and sleep time (< 10 h). Conclusion In conclusion, children’s gender, bone age, exercise habits, E2, FSH, LH, leptin, mother’s menarche time, living environment, eating habits, sleep time and other factors are closely related to precocious puberty in children. Reminding parents to actively prevent related factors in clinical work is helpful to prevent the occurrence of precocious puberty in children.

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Section: Introductionmentioning

confidence: 99%

Analysis of risk factors of precocious puberty in children

Dong,

Dai,

Dong

et al. 2023

BMC Pediatr

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“…Endocrine genetics is a rapidly developing new component of endocrinology and of everyday clinical endocrine practice. This issue of Hormones includes observations recently made in children with neurofibromatosis type 1 [14] and a case of salt-wasting congenital adrenal hyperplasia due to TNXA/TNXB chimera [15].…”

mentioning

confidence: 99%

COVID-19, diabetes mellitus type 2, endocrine genetics, and pituitary and adrenal diseases

Stratakis

2023

Hormones

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Endocrine morbidity in neurofibromatosis 1: a nationwide, register-based cohort study

Kenborg

Ebbehøj

Ejerskov

et al. 2023

European Journal of Endocrinology

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Objective Previous studies have found that neurofibromatosis 1 (NF1) is associated with an increased risk for endocrine disorders, but no comprehensive overview of the risk for specific endocrine disorders has been published. We assessed endocrine morbidity in individuals with NF1 from information on hospital admissions, surgery for endocrine disorders, and relevant medication. Design A nationwide population registry-based cohort study. Methods We identified 2467 individuals with NF1 diagnosed between 1977–2013 from the Danish National Patient Register and the RAREDIS database and 20 132 randomly sampled age- and sex-matched population comparisons. Information on endocrine diseases was identified using registrations of discharge diagnoses, surgery, and medication prescriptions. The rates of endocrine disorders in individuals with NF1 were compared with those in the comparison cohort in Cox proportional hazard models. Results Individuals with NF1 had a higher rate than the comparison group of any endocrine discharge diagnosis (hazard ratio (HR) 1.72, 95% confidence interval (CI): 1.58–1.87), endocrine-related surgery (2.03, 1.39–2.96), and prescribed medications (1.32, 1.23–1.42). Increased HRs were observed for diseases and surgical operations of several glands, including pheochromocytoma, and for osteoporosis, and osteoporotic fractures. Decreased rates were observed with drugs for type 2 diabetes. Women with NF1 had higher HRs for surgery of the ovaries, uterus, and sterilization, but lower rates of surgeries of cervix and prescriptions for birth control pills. Conclusions NF1 is associated with a variety of endocrine disorders, surgery, and medication related to endocrine disease. Awareness of endocrine morbidity is important in the clinical follow-up of individuals with NF1.

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Precocious and accelerated puberty in children with neurofibromatosis type 1: results from a close follow-up of a cohort of 45 patients

Cited by 4 publications

References 22 publications

Analysis of risk factors of precocious puberty in children

Analysis of risk factors of precocious puberty in children

COVID-19, diabetes mellitus type 2, endocrine genetics, and pituitary and adrenal diseases

Endocrine morbidity in neurofibromatosis 1: a nationwide, register-based cohort study

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