Preclinical Ultra-High Dose Rate (FLASH) Proton Radiation Therapy System for Small Animal Studies

Cao, Ning; Erickson, Danielle P. Johnson; Ford, Eric C.; Emery, Robert C.; Kranz, Marissa; Goff, Peter; Schwarz, Marco; Meyer, Juergen; Wong, Tony; Saini, Jatinder; Bloch, Charles; Stewart, Robert D.; Sandison, George A.; Morimoto, Alec; DeLonais-Dick, Ava; Shaver, Ben A.; Rengan, Ramesh; Zeng, Jing

doi:10.1016/j.adro.2023.101425

Advances in Radiation Oncology

2024

DOI: 10.1016/j.adro.2023.101425

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Preclinical Ultra-High Dose Rate (FLASH) Proton Radiation Therapy System for Small Animal Studies

Ning Cao,

Danielle P. Johnson Erickson,

Eric C. Ford

et al.

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The FLASH effect—an evaluation of preclinical studies of ultra-high dose rate radiotherapy

McGarrigle,

Long,

Prezado

2024

Front. Oncol.

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FLASH radiotherapy (FLASH-RT) is a novel radiotherapy approach based on the use of ultra-high dose radiation to treat malignant cells. Although tumours can be reduced or eradicated using radiotherapy, toxicities induced by radiation can compromise healthy tissues. The FLASH effect is the observation that treatment delivered at an ultra-high dose rate is able to reduce adverse toxicities present at conventional dose rates. While this novel technique may provide a turning point for clinical practice, the exact mechanisms underlying the causes or influences of the FLASH effect are not fully understood. The study presented here uses data collected from 41 experimental investigations (published before March 2024) of the FLASH effect. Searchable databases were constructed to contain the outcomes of the various experiments in addition to values of beam parameters that may have a bearing on the FLASH effect. An in-depth review of the impact of the key beam parameters on the results of the experiments was carried out. Correlations between parameter values and experimental outcomes were studied. Pulse Dose Rate had positive correlations with almost all end points, suggesting viability of FLASH-RT as a new modality of radiotherapy. The collective results of this systematic review study suggest that beam parameter qualities from both FLASH and conventional radiotherapy can be valuable for tissue sparing and effective tumour treatment.

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The FLASH effect—an evaluation of preclinical studies of ultra-high dose rate radiotherapy

McGarrigle,

Long,

Prezado

2024

Front. Oncol.

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show abstract

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Preclinical Ultra-High Dose Rate (FLASH) Proton Radiation Therapy System for Small Animal Studies

Cited by 1 publication

References 23 publications

The FLASH effect—an evaluation of preclinical studies of ultra-high dose rate radiotherapy

The FLASH effect—an evaluation of preclinical studies of ultra-high dose rate radiotherapy

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