Preclinical toxicological study of long-circulating and fusogenic liposomes co-encapsulating paclitaxel and doxorubicin in synergic ratio

Roque, Marjorie Coimbra; Silva, Caroline Dohanik da; Lempek, Marthin Raboch; Cassali, Geovanni Dantas; Barros, André Luís Branco de; Melo, Marília Martins; Oliveira, Mônica Cristina

doi:10.1016/j.biopha.2021.112307

Cited by 7 publications

(1 citation statement)

References 39 publications

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“…The co-delivery approach can be based on the joint administration of different single drugcontaining NPs as well as dual drug-loaded delivery systems. However, it has been shown in numerous papers that the best results are observed for co-loaded systems as opposed to the combination of two separate drug nanoformulations [304,465,466]. A combination of two small drugs with different activities [130,467] or a small drug with a gene therapy agent [342] is usually used to obtain dual drug-loaded systems.…”

Section: Cancer Treatmentmentioning

confidence: 99%

Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery

Stepanova,

Nikiforov,

Tennikova

et al. 2023

Pharmaceutics

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Synthetic polypeptides are biocompatible and biodegradable macromolecules whose composition and architecture can vary over a wide range. Their unique ability to form secondary structures, as well as different pathways of modification and biofunctionalization due to the diversity of amino acids, provide variation in the physicochemical and biological properties of polypeptide-containing materials. In this review article, we summarize the advances in the synthesis of polypeptides and their copolymers and the application of these systems for drug delivery in the form of (nano)particles or hydrogels. The issues, such as the diversity of polypeptide-containing (nano)particle types, the methods for their preparation and drug loading, as well as the influence of physicochemical characteristics on stability, degradability, cellular uptake, cytotoxicity, hemolysis, and immunogenicity of polypeptide-containing nanoparticles and their drug formulations, are comprehensively discussed. Finally, recent advances in the development of certain drug nanoformulations for peptides, proteins, gene delivery, cancer therapy, and antimicrobial and anti-inflammatory systems are summarized.

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