Preclinical Testing Techniques: Paving the Way for New Oncology Screening Approaches
Antonia van Rijt,
Evan Stefanek,
Karolina Valente
Abstract:Prior to clinical trials, preclinical testing of oncology drug candidates is performed by evaluating drug candidates with in vitro and in vivo platforms. For in vivo testing, animal models are used to evaluate the toxicity and efficacy of drug candidates. However, animal models often display poor translational results as many drugs that pass preclinical testing fail when tested with humans, with oncology drugs exhibiting especially poor acceptance rates. The FDA Modernization Act 2.0 promotes alternative precl… Show more
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