Preclinical Study of Biofunctional Polymer-Coated Upconversion Nanoparticles

Guryev, Evgenii L.; Shilyagina, Natalia Yu.; Kostyuk, A. B.; Sencha, Ludmila M; Balalaeva, Irina V.; Vodeneev, Vladimir; Kutova, Olga M.; Lyubeshkin, A. V.; Yakubovskaya, Raisa I.; Панкратов, А. А.; Ingel, Faina I.; Novik, Tamara S; Deyev, Sergey M.; Ermilov, Sergey A.; Zvyagin, Andrei V.

doi:10.1093/toxsci/kfz086

Cited by 28 publications

(19 citation statements)

References 41 publications

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“…The use of UCNP, in relation to their unique photophysical properties, makes it possible to significantly expand the capabilities of traditional methods of optical diagnostics, which are based on the use of organic dyes and fluorescent proteins as labels for visualizing pathological targets [ 4 ]. In addition, nanoparticles serve as an excellent platform for the creation of multicomponent theranostic complexes by attaching to them targeted and toxic modules (for example, chemotherapy and radiotherapy agents, protein toxins) to target a specific type of tumors [ 5 , 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…The combination of photophysical and chemical properties of UCNP makes them highly demanded agents for intravital labeling of various targets, including tumor cells [ 8 , 9 , 10 , 11 ]. The possibility of attaching additional targeting and therapeutic components to UCNP surface makes it possible to obtain multifunctional agents for a variety of theranostic applications [ 5 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

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UCNP-based Photoluminescent Nanomedicines for Targeted Imaging and Theranostics of Cancer

et al. 2020

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Theranostic approach is currently among the fastest growing trends in cancer treatment. It implies the creation of multifunctional agents for simultaneous precise diagnosis and targeted impact on tumor cells. A new type of theranostic complexes was created based on NaYF4: Yb,Tm upconversion nanoparticles coated with polyethylene glycol and functionalized with the HER2-specific recombinant targeted toxin DARPin-LoPE. The obtained agents bind to HER2-overexpressing human breast adenocarcinoma cells and demonstrate selective cytotoxicity against this type of cancer cells. Using fluorescent human breast adenocarcinoma xenograft models, the possibility of intravital visualization of the UCNP-based complexes biodistribution and accumulation in tumor was demonstrated.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

UCNP-based Photoluminescent Nanomedicines for Targeted Imaging and Theranostics of Cancer

et al. 2020

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“…Today new technologies, methods and procedures have been developed with the help of photoconversion materials. Leaders in the creation, research and implementation of photoconversion materials are theranostics, biophotonics and a number of areas of physics associated with the creation of devices operating on the basis of sunlight [11][12][13][14]. The use of such technologies in agriculture is often limited to closed grounds (greenhouses, greenhouses, hotbeds, etc.)…”

Section: Introductionmentioning

confidence: 99%

Influence of Fluoropolymer Film Modified With Nanoscale Photoluminophor on Growth and Development of Plants

et al. 2020

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The red and blue ranges of the optical spectrum are most suitable for plant photosynthesis. Moreover, quanta of red light stimulate photosynthesis more than quanta of blue light. In northern latitudes, the average daily intensity of the red and blue parts of the spectrum is usually not sufficient for many plants. To increase the productivity of greenhouses in northern latitudes, a technology has been developed for fluoropolymer films with photoconversion nanoparticles (quantum dots) that convert UV radiation and violet light into red light. The use of photoconversion fluoropolymer films promotes an increase in the biomass of plants grown in greenhouses at high latitudes. The greatest effect is observed when tomato plants are grown under photoconversion fluoropolymer films. The biomass of tomato berry obtained from one bush grown under films is 20% higher than the biomass of berry of control tomato plants.

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“…DARPin 9_29 was covalently bound to upconverting radioactive nanoparticles coated with a maleic anhydride and 1-octadecene (PMAO) copolymer. The resulting nanoparticles were used to visualize breast tumors in a xenograft mouse model and exhibited low side toxicity in vivo [84]. The same conjugation method was applied to functionalize upconverting nanoparticles with the DARPin-mCherry protein [43].…”

Section: Application Of Darpins In Nanoparticle Deliverymentioning

confidence: 99%

DARPins: Promising Scaffolds for Theranostics

Shilova

Deyev

2019

Acta Naturae

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Monoclonal antibodies are the classical basis for targeted therapy, but the development of alternative binding proteins has made it possible to use non-immunoglobulin proteins as targeting modules. The advantages of DARPins, scaffold proteins based on ankyrin repeats, over antibodies are as follows: small size, stability over a wide range of temperatures and pH values, low aggregation tendency, and ease of production in heterologous expression systems. The differences in the structure of the paratope of DARPin and antibodies broaden the spectrum of target molecules, while the ease of creating hybrid fusion proteins allows one to obtain bispecific and multivalent constructs. In this article, we summarize recent data on the development of therapeutic and imaging compounds based on DARPins.

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Preclinical Study of Biofunctional Polymer-Coated Upconversion Nanoparticles

Cited by 28 publications

References 41 publications

UCNP-based Photoluminescent Nanomedicines for Targeted Imaging and Theranostics of Cancer

UCNP-based Photoluminescent Nanomedicines for Targeted Imaging and Theranostics of Cancer

Influence of Fluoropolymer Film Modified With Nanoscale Photoluminophor on Growth and Development of Plants

DARPins: Promising Scaffolds for Theranostics

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