Preclinical studies with the Faure high energy neutron facility: response of pig skin to fractionated doses of fast neutrons (66 MeVp → Be)

Blekkenhorst, G.; Hendrikse, A.; Kent, Charles R. H.; Jones, D. T. L.; Aardweg, G.J.M.J. van den

doi:10.1016/0167-8140(90)90140-r

Cited by 7 publications

(3 citation statements)

References 17 publications

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“…Typically, RBEs (relative biological effectiveness) for neutrons are between 2 and 5, varying with factors such as dose, endpoint and neutron energy [33]. RBEs of approximately 3 were found for moist desquamation and late dermal necrosis in pig skin (a model of human skin) using the neutron beam in this study (66 MeV pǞBe vs. 60 Co) for fractionated schedules similar to the clinical schedules described [4]. To achieve a therapeutic gain, the tumor RBE should be greater than normal tissue RBE.…”

Section: Introductionmentioning

confidence: 69%

Neutron Versus Photon Radiotherapy for Local Control in Inoperable Breast Cancer

et al. 2005

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Section: Introductionmentioning

confidence: 69%

Neutron Versus Photon Radiotherapy for Local Control in Inoperable Breast Cancer

et al. 2005

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“…Radiobiologists from Groote Schuur and Tygerberg Hospitals and the National Accelerator Centre undertook biological calibration experiments and conducted scientific investigations using the latest techniques, which contributed to the clinical utilisation and better understanding of these novel radiation modalities. 20,21,22,23,24,25 Research and teaching activities were cultivated and, up until 2002, the radiobiological momentum produced over 20 postgraduate degrees from Stellenbosch University and the University of Cape Town, but none have been produced since.…”

Section: The Importance Of Developing Scientific Competence In Radiob...mentioning

confidence: 99%

Radiation biology – An important science for an advanced nuclear nation like South Africa

Hunter

2012

S Afr J Sci

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The sustainability of radiation biology (radiobiology) is under threat in South Africa because of underdevelopment in the discipline, despite the fact that South Africa has been a user of radiation since radioactivity and X-rays were discovered. The widespread use of radiation in medicine, nuclear reactors, particle accelerators and other sophisticated nuclear facilities in South Africa makes it imperative that the interaction of radiation with biological systems is understood. For example, radiobiology is critical in radiation oncology and cancer treatment. Radiobiology is a distinctly biological science and its uniqueness and value should be highlighted to provide insight for authorities and other relevant parties. Regrettably, radiobiology has been largely neglected despite the importance of maintaining expertise and competence in this discipline. Many radiation-associated disciplines require radiobiology for their training and practice yet few radiobiologists are available nationally. The scientific community needs to be informed of the predicament of radiobiology in South Africa so that the situation can be addressed. Radiobiology is a scarce skill that needs to be developed to support South Africa's mature radiation infrastructure. The country has too few radiobiologist training programmes and there is a lack of succession planning. Radiobiology is required for training and practice in a number of disciplines that use radiation, but, as a result of a shortage of qualified personnel, teaching of radiobiology has frequently been conducted by non-experts. To reinvigorate radiobiology in South Africa, a collective effort by government, academia, industry and allied professionals is required.

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“…ducreyi is primarily a cutaneous pathogen; while involvement of regional lymph nodes is not uncommon in chancroid, H. ducreyi is seldom recovered from bubo aspirates (25), and the bacteria do not invade deeper tissue or cause systemic disease (34). Because the skin of juvenile pigs closely resembles human skin both structurally and physiologically (6,13,23,26,32,55,56), we investigated the ability of H. ducreyi to cause dermal lesions in swine. Lesions histologically resembling natural human chancres developed in pig skin following inoculation through abrasions in the epithelium, providing a useful animal model for the study of H. ducreyi pathogenesis and host response to infection.…”

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confidence: 99%

Swine model of Haemophilus ducreyi infection

et al. 1995

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Haemophilus ducreyi is a strict human pathogen that causes sexually transmitted genital ulcer disease. We infected domestic swine with H. ducreyi 35000, resulting in the development of cutaneous ulcers histologically resembling human chancroid lesions. Intraepidermal lesions progressed from pustules to ulcers containing polymorphonuclear leukocytes and were accompanied by a dermal inflammatory infiltrate containing T cells and macrophages. H. ducreyi was recovered from lesions up to 17 days after inoculation, and pigs did not develop immunity to reinfection with the challenge strain. Features of the model include inoculation through abrasions in the epidermis, ambient housing temperatures for infected pigs, the ability to deliver multiple different inocula to a single host, and the availability of monoclonal antibodies against porcine immune cells permitting immunohistochemical characterization of the host immune response to H. ducreyi infection.

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Preclinical studies with the Faure high energy neutron facility: response of pig skin to fractionated doses of fast neutrons (66 MeVp → Be)

Cited by 7 publications

References 17 publications

Neutron Versus Photon Radiotherapy for Local Control in Inoperable Breast Cancer

Neutron Versus Photon Radiotherapy for Local Control in Inoperable Breast Cancer

Radiation biology – An important science for an advanced nuclear nation like South Africa

Swine model of Haemophilus ducreyi infection

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