Preclinical regulatory validation of an engineered diaphragmatic tendon made with amniotic mesenchymal stem cells

Turner, Christopher G.; Klein, Jessica; Steigman, Shaun A.; Armant, Myriam; Nicksa, Grace A.; Zurakowski, David; Ritz, Jérôme; Fauza, Dario O.

doi:10.1016/j.jpedsurg.2010.09.063

Cited by 70 publications

(36 citation statements)

References 20 publications

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“…For example, recent large animal studies have shown that the repair of congenital diaphragmatic hernia, tracheal, chest wall and craniofacial defects can be enhanced by the respective use of tendon, cartilaginous/airway, or bone grafts engineered from aMSCs during surgical reconstruction (Figs. 26.4 and 26.5) [24,32,33,37,39,40,43,44]. Another …”

Section: Amscsmentioning

confidence: 96%

Tissue Engineering and Transplantation in the Fetus

Fauza

2014

Principles of Tissue Engineering

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Section: Amscsmentioning

confidence: 96%

Tissue Engineering and Transplantation in the Fetus

Fauza

2014

Principles of Tissue Engineering

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“…Mesenchymal stem cells (MSCs), hematopoietic stem cells (HSCs) and amniotic fluid stem cells are all multipotent cells which can easily be obtained from recipient tissues without any ethical concerns. These kind of cells have been successfully used in many experimental studies [18][19][20]. The advantages of multipotent cells include their differentiation capacity, good availability, immunomodulatory effects and no need for immunosuppressive medication.…”

Section: Cellsmentioning

confidence: 99%

Current status of tracheal tissue engineering

Kumbasar¹,

Uysal²

2017

Curr Thorac Surg

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Management of large airway defects is challenging for clinicians due to lack of effective treatment modalities and eventually interest has turned to the field of airway tissue engineering. Considerable progress has been made within the field of airway tissue engineering in recent years and herein we review these recent advances within this field as applied to regeneration and/or replacement of the trachea. Although there are many encouraging researches, we are still far from any routine clinical application of tissue engineered tracheal grafts and it is essential to perform further experimental and clinical researches in order to improve current results and to broaden the clinical application of airway tissue engineering.

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“…Furthermore, compared with ESCs, AFSCs do not require human embryo tissue for their isolation, thus avoiding current ethical issues, suggesting that stem cells present in the amniotic fluid might be promising candidates for tissue engineering. Importantly, several studies have demonstrated that AFSCs present a proangiogenic effect that recruits the host's progenitor cells to sites of AFSCs implantation [62,126,127]. To date, AFSCs have exhibited many promising properties and have attracted global attention.…”

Section: Amniotic Fluid Stem Cellsmentioning

confidence: 99%

Re-Epithelialization: A Key Element in Tracheal Tissue Engineering

Zhang

2015

Regen. Med.

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Trachea-tissue engineering is a thriving new field in regenerative medicine that is reaching maturity and yielding numerous promising results. In view of the crucial role that the epithelium plays in the trachea, re-epithelialization of tracheal substitutes has gradually emerged as the focus of studies in tissue-engineered trachea. Recent progress in our understanding of stem cell biology, growth factor interactions and transplantation immunobiology offer the prospect of optimization of a tissue-engineered tracheal epithelium. In addition, advances in cell culture technology and successful applications of clinical transplantation are opening up new avenues for the construction of a tissue-engineered tracheal epithelium. Therefore, this review summarizes current advances, unresolved obstacles and future directions in the reconstruction of a tissue-engineered tracheal epithelium.

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Preclinical regulatory validation of an engineered diaphragmatic tendon made with amniotic mesenchymal stem cells

Cited by 70 publications

References 20 publications

Tissue Engineering and Transplantation in the Fetus

Tissue Engineering and Transplantation in the Fetus

Current status of tracheal tissue engineering

Re-Epithelialization: A Key Element in Tracheal Tissue Engineering

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