“…One of the peptides that displayed bold characteristics as a radiotracer for HER2 imaging is a peptide with the sequence Leu-Thr-Val-Pro-Trp-Tyr (LTVPWY). The reports suggest that 99m Tc-radiolabeled derivatives of LTVPWY ( 99m Tc-HYNIC-(Ser) 3 -LTVPWY) not only bind to HER2 overexpressing ovarian tumor xenografts but also successfully visualize GBM xenografts [6,15,16]. Moreover, DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)-conjugated LTVSPWY is also evaluated for ovarian tumor xenografts with the overexpression of HER2 receptor after radiolabeling with 68 -Galium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaceticacid-Ser-Ser-Ser-Leu-Thr-Val-Ser-Pro-Trp-Tyr ( 68 Ga-DOTA-(Ser)3-LTVSPWY) [17].…”