Preclinical Molecular Signatures of Spinal Cord Functional Restoration: Optimizing the Metamorphic Axolotl (<i>Ambystoma mexicanum</i>) Model in Regenerative Medicine

Demircan, Turan; Hacıbektaşoğlu, Harbiye; Sibai, Mustafa; Fesçioğlu, Ece Cana; Altuntaş, Ebru; Öztürk, Gürkan; Süzek, Barış E.

doi:10.1089/omi.2020.0024

Cited by 9 publications

(9 citation statements)

References 47 publications

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“…The blastema is a region of dedifferentiated cells that forms from underlying tissues at the site of injury. 13,21,38,119,[123][124][125] This transient structure interacts with the wound epidermis in similar ways to mesodermal-epidermal interactions seen during embryonic development. 55,88 However, dedifferentiation and blastemal formation are not sufficient to drive the formation of a fully functional and patterned limb or tail after amputation.…”

Section: The Ultimate Regeneratormentioning

confidence: 84%

“…One of the secrets to axolotl limb and tail regeneration lies in its ability to form a blastema after injury. The blastema is a region of dedifferentiated cells that forms from underlying tissues at the site of injury 13,21,38,119,123‐125 . This transient structure interacts with the wound epidermis in similar ways to mesodermal–epidermal interactions seen during embryonic development 55,88 .…”

Section: The Ultimate Regeneratormentioning

confidence: 99%

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The amazing and anomalous axolotls as scientific models

Adamson

Morrison-Welch

Rogers

2022

Developmental Dynamics

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Ambystoma mexicanum (axolotl) embryos and juveniles have been used as model organisms for developmental and regenerative research for many years. This neotenic aquatic species maintains the unique capability to regenerate most, if not all, of its tissues well into adulthood. With large externally developing embryos, axolotls were one of the original model species for developmental biology. However, increased access to, and use of, organisms with sequenced and annotated genomes, such as Xenopus laevis and tropicalis and Danio rerio, reduced the prevalence of axolotls as models in embryogenesis studies. Recent sequencing of the large axolotl genome opens up new possibilities for defining the recipes that drive the formation and regeneration of tissues like the limbs and spinal cord. However, to decode the large A. mexicanum genome will take a herculean effort, community resources, and the development of novel techniques. Here, we provide an updated axolotl‐staging chart ranging from one‐cell stage to immature adult, paired with a perspective on both historical and current axolotl research that spans from their use in early studies of development to the recent cutting‐edge research, employment of transgenesis, high‐resolution imaging, and study of mechanisms deployed in regeneration.

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Section: The Ultimate Regeneratormentioning

confidence: 84%

Section: The Ultimate Regeneratormentioning

confidence: 99%

The amazing and anomalous axolotls as scientific models

Adamson

Morrison-Welch

Rogers

2022

Developmental Dynamics

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“…In relations with the TUBA1B expresión, we observe that TUBA1B presented the lowest value estimate the pooled effect size of log2 fold change (−1.4919 [95%-CI=−1.4964; −1.4873]) to 5 transcriptomic studies in the context of PD, According to Independent Enrichment Analysis of gene sets the TUBA1B is a component of the Gonadotropin releasing hormone receptor pathway (P06664) as well as NOS1 and DRD2, The effect of Gonadotropin releasing hormone receptor pathway in PD is a controversial topic[46]; however, Gonadotropin releasing hormone receptor pathway the has been demonstrated participate in the process of Neuronal Survival [47, 48] that in parkinson’s context where is observed neuron decline subependymal zone, subgranular zone and the midbrain, It is possible to draw a picture in which alteration in the Neuronal Survival mechanism can contribute to the decrease of neurons in these areas, in addition to the TUBA1B downrelation, we propose that hsa-miR-23b-3p, hsa-miR-2277-3p, hsa-miR-342-5p, hsa-miR-155-5p, hsa-miR-30b-3p, hsa-miR-193b-3p, hsa-miR-221-5p, hsa-miR-744-5p, hsa-miR-126-5p, hsa-miR-28-5p, hsa-miR-182-5p, hsa-miR-212-3p and hsa-miR-3150a-5p (figure.5) found upregulated in parkinson patient [49] and experimentally shown to target TUBA1B[50], which the TUBA1B downrelation may have a key role in regulation of dopaminergic neurons Survival in parkinson’s context[51, 52].…”

Section: Discussionmentioning

confidence: 99%

Differential gene expression in the interactome of the Human Dopamine transporter in the context of Parkinson’s disease

Navarro

Scott

Philot

et al. 2020

Preprint

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Background: The human dopamine transporter is the main regulator of dopamine tone and an intricate network exists to regulate the expression, conformation, and kinetics of the hDAT. hDAT dysfunction is directly related to Parkinson's disease. The objective of this work is to evaluate the differential gene expression in the interactome of the Dopamine transporter in the context of Parkinson's disease. Methods:To do this, we evaluated hDAT interaction data in string-db, mint.bio, IntAct, reactome, hprd and BioGRID, subsequently, data was obtained from the differential gene expression of mRNA and miRNAs for this hDAT interactome in the context of PD. Results: The analysis of the differential expression changes of genes of the hDAT interactome in tissues of patients with PD compared with tissues of individuals without PD, allowed to identify an expression pattern of 32 components of the hDAT interactome, of which 31 presented a negative change proportion in PD. Conclusions: We found a total of 90 miRNAs that could regulate the expression of 27 components of the hDAT interactome, at the same time, 39 components of the hDAT interactome may participate in 40 metabolic pathways. Together, these findings show a systematic effect on the hDAT-mediated dopamine internalization process in patients with Parkinson's, which would contribute to a greater susceptibility to neuronal oxidative stress in PD patients.

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“…It can also repair other tissues-such as the retinal tissues-and heal wounds without leaving scars. They can also easily accept transplants from other individuals, including the eyes and parts of the brain, restoring their full functionality [33].…”

Section: The Axolotl In Naturementioning

confidence: 99%

Mexican Axolotl Optimization: A Novel Bioinspired Heuristic

et al. 2021

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When facing certain problems in science, engineering or technology, it is not enough to find a solution, but it is essential to seek and find the best possible solution through optimization. In many cases the exact optimization procedures are not applicable due to the great computational complexity of the problems. As an alternative to exact optimization, there are approximate optimization algorithms, whose purpose is to reduce computational complexity by pruning some areas of the problem search space. To achieve this, researchers have been inspired by nature, because animals and plants tend to optimize many of their life processes. The purpose of this research is to design a novel bioinspired algorithm for numeric optimization: the Mexican Axolotl Optimization algorithm. The effectiveness of our proposal was compared against nine optimization algorithms (artificial bee colony, cuckoo search, dragonfly algorithm, differential evolution, firefly algorithm, fitness dependent optimizer, whale optimization algorithm, monarch butterfly optimization, and slime mould algorithm) when applied over four sets of benchmark functions (unimodal, multimodal, composite and competition functions). The statistical analysis shows the ability of Mexican Axolotl Optimization algorithm of obtained very good optimization results in all experiments, except for composite functions, where the Mexican Axolotl Optimization algorithm exhibits an average performance.

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Preclinical Molecular Signatures of Spinal Cord Functional Restoration: Optimizing the Metamorphic Axolotl (Ambystoma mexicanum) Model in Regenerative Medicine

Cited by 9 publications

References 47 publications

The amazing and anomalous axolotls as scientific models

The amazing and anomalous axolotls as scientific models

Differential gene expression in the interactome of the Human Dopamine transporter in the context of Parkinson’s disease

Mexican Axolotl Optimization: A Novel Bioinspired Heuristic

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