Preclinical models of medication-related osteonecrosis of the jaw (MRONJ)

Aguirre, J. Ignacio; Castillo, E.J.; Kimmel, Donald B.

doi:10.1016/j.bone.2021.116184

Cited by 35 publications

(31 citation statements)

References 302 publications

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“…MRONJ is more common in cancer patients (1.8–5% incidence) than osteoporosis patients (0.01–0.03% incidence); this is partly due to the medical condition, but also the doses and potency of AR or AA drugs used. It can lead to debilitating effects due to unexplained causes [ 27 , 28 ]. The first series of cases of osteonecrosis of the jaw related to medications were reported by Marx at the University of Miami in 2003 and involved 36 cases of painful bony exposure in the maxilla and mandible that were not responding to any surgical or medical treatment in patients receiving intravenous bisphosphonates [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Teledentistry as a Supportive Tool for Dentists in Diagnosing MRONJ in Northern Cyprus

Firincioglulari

Orhan

2021

BioMed Research International

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Objective. This web-based survey, as a tool of teledentistry, is aimed at assessing the level of knowledge, attitudes, and awareness regarding MRONJ among dental professionals in Northern Cyprus. Methods. An online self-administered questionnaire about MRONJ was sent to all dentists in Northern Cyprus through Google Forms. The first part of the questionnaire consists of demographic and professional information, and the second part included questions about knowledge and awareness questions about MRONJ. The SPSS software was used for statistical data analysis. A Chi-square test was performed to compare between the groups. The significance level was set at p < 0.05 . Results. A total of 112 dentists participated in this survey. The participants showed an insufficient level of knowledge regarding MRONJ, as only 56.6% of the participants stated that they had general knowledge about MRONJ. Regarding the practical questions of the survey, the participants showed poor knowledge about implant and tooth extraction procedures while a patient is using antiresorptive or antiangiogenic drugs, particularly the usage of oral antiresorptive or antiangiogenic drugs for less than 3 years. Participants showed adequate knowledge in terms of usage area of medications and administration of them. Conclusion. Teledentistry can be used as a supportive tool for dentists in diagnosing MRONJ. Similar to previous studies, the knowledge and awareness of MRONJ of dentists in Northern Cyprus were found to be inadequate. There is a significant need to provide more professional information as part of undergraduate programs so that the next generation of dentists can practice more confidently.

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Section: Discussionmentioning

confidence: 99%

Teledentistry as a Supportive Tool for Dentists in Diagnosing MRONJ in Northern Cyprus

Firincioglulari

Orhan

2021

BioMed Research International

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“…Compared with large vertebrates, rodents have universal benefits of easy feeding and operation and relatively low cost. Among all kinds of MRONJ animal models from 2003 to date, most were rodents, as 60% were rats, 27% were mice, and 2% were rice rats 16 . Large vertebrates such as dogs (~4%), pigs (~3%), and sheep (~2%) have also been applied to establish MRONJ models 16 .…”

Section: Introductionmentioning

confidence: 99%

“…Among all kinds of MRONJ animal models from 2003 to date, most were rodents, as 60% were rats, 27% were mice, and 2% were rice rats 16 . Large vertebrates such as dogs (~4%), pigs (~3%), and sheep (~2%) have also been applied to establish MRONJ models 16 . However, rodents boast additional advantages in MRONJ research because the presence of Haversian remodeling in large vertebrates is not involved in the development of MRONJ.…”

Section: Introductionmentioning

confidence: 99%

“…1 Footprints of MRONJ rodent models. Representative MRONJ rodent models from 2009 to 2021 were established by Sonis et al 111 , Mawardi et al 112 , Aghaloo et al 79 , Aguirre et al 16 , Kang et al 41 , Williams et al 76 , Kim et al 26 , Curra et al 6 , Rao et al 81 , and Mine et al 113 …”

Section: Introductionmentioning

confidence: 99%

“…Another powerful model for spontaneous periodontitis, the rice rat, has also been utilized in MRONJ research 20 , 21 . Apart from different local risk factors adopted in establishing models, to further simulate abnormal bone tissue metabolism conditions exhibited by MRONJ patients, such as osteoporosis, researchers have created MRONJ models based on ovariectomized (OVX) rodents 8 , 16 , 22 – 28 .…”

Section: Introductionmentioning

confidence: 99%

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Establishment and assessment of rodent models of medication-related osteonecrosis of the jaw (MRONJ)

Yan

Jiang

et al. 2022

Int J Oral Sci

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Medication-related osteonecrosis of the jaw (MRONJ) is primarily associated with administering antiresorptive or antiangiogenic drugs. Despite significant research on MRONJ, its pathogenesis and effective treatments are still not fully understood. Animal models can be used to simulate the pathophysiological features of MRONJ, serving as standardized in vivo experimental platforms to explore the pathogenesis and therapies of MRONJ. Rodent models exhibit excellent effectiveness and high reproducibility in mimicking human MRONJ, but classical methods cannot achieve a complete replica of the pathogenesis of MRONJ. Modified rodent models have been reported with improvements for better mimicking of MRONJ onset in clinic. This review summarizes representative classical and modified rodent models of MRONJ created through various combinations of systemic drug induction and local stimulation and discusses their effectiveness and efficiency. Currently, there is a lack of a unified assessment system for MRONJ models, which hinders a standard definition of MRONJ-like lesions in rodents. Therefore, this review comprehensively summarizes assessment systems based on published peer-review articles, including new approaches in gross observation, histological assessments, radiographic assessments, and serological assessments. This review can serve as a reference for model establishment and evaluation in future preclinical studies on MRONJ.

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Medication‐related osteonecrosis of the jaw: A literature review and update

Kuroshima

Al-Omari

Sasaki

et al. 2022

Genesis

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Since the initial description of medication-related osteonecrosis of the jaw (MRONJ) almost two decades ago, the potential pathophysiology and risk factors have been elaborated on in many investigations and guidelines. However, the definitive pathophysiology based on scientific evidence remains lacking. Consequently, the optimal clinical treatment and prevention strategies for MRONJ have not been established.Despite their different mechanisms of action, many drugs, including bisphosphonates, denosumab, angiogenesis inhibitors, and other medications, have been reported to be associated with MRONJ lesions in cancer and osteoporosis patients. Importantly, MRONJ occurs predominantly in the jawbones and other craniofacial regions, but not in the appendicular skeleton. In this up-to-date review, the currently available information and theories regarding MRONJ are presented from both clinical and basic science perspectives. The definition and epidemiology of MRONJ, triggering medication, and histopathology are comprehensively summarized. The immunopathology and the

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Preclinical models of medication-related osteonecrosis of the jaw (MRONJ)

Cited by 35 publications

References 302 publications

Teledentistry as a Supportive Tool for Dentists in Diagnosing MRONJ in Northern Cyprus

Teledentistry as a Supportive Tool for Dentists in Diagnosing MRONJ in Northern Cyprus

Establishment and assessment of rodent models of medication-related osteonecrosis of the jaw (MRONJ)

Medication‐related osteonecrosis of the jaw: A literature review and update

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