Preclinical model for lumbar interbody fusion in small ruminants: Rationale and guideline

Duits, Anneli; Salvatori, Daniela; Schouten, Jacobine; Urk, Paul van; Gaalen, Steven van; Ottink, Karsten D.; Öner, Cuhmur; Kruyt, Moyo C.

doi:10.1016/j.jot.2022.10.006

Cited by 3 publications

(3 citation statements)

References 61 publications

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“…To further validate the antipullout capability of the screw, a large-animal model was used for in vivo experiment. Goats are widely used in spinal surgery models because of their analogy to the human spine with the similar disc geometries, biomechanical and pathologic features. , Therefore, a goat model was considered for the implantation of pedicle screws for practical and translational reasons. All screws were well placed, and no misalignment occurred after one year of breeding.…”

Section: Discussionmentioning

confidence: 99%

3D Printed Pedicle Screws with Microarc Oxidation Ceramic Interfaces Enhance Osteointegration and Orthopedic Fixation Feasibility

Chen,

Wang,

Yang

et al. 2024

ACS Appl. Mater. Interfaces

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Section: Discussionmentioning

confidence: 99%

3D Printed Pedicle Screws with Microarc Oxidation Ceramic Interfaces Enhance Osteointegration and Orthopedic Fixation Feasibility

Chen,

Wang,

Yang

et al. 2024

ACS Appl. Mater. Interfaces

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“…Photon-counting detector CT is an existing new development that can provide high-quality, ultra-high-resolution images 43,44 to substitute surgical exploration are of utmost importance to improve and standardize image-based fusion assessment. Large animal IF models and postmortem studies should be used to test the diagnostic accuracy of fusion classifications using improved imaging techniques, for both innovative and standard implants, compared with manual palpation and histologic assessment 45 .…”

Section: Future Researchmentioning

confidence: 99%

Radiologic Assessment of Interbody Fusion

Duits,

van Urk,

Lehr

et al. 2024

JBJS Reviews

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Background: Lumbar interbody fusion (IF) is a common procedure to fuse the anterior spine. However, a lack of consensus on image-based fusion assessment limits the validity and comparison of IF studies. This systematic review aims to (1) report on IF assessment strategies and definitions and (2) summarize available literature on the diagnostic reliability and accuracy of these assessments. Methods: Two searches were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Search 1 identified studies on adult lumbar IF that provided a detailed description of image-based fusion assessment. Search 2 analyzed studies on the reliability of specific fusion criteria/classifications and the accuracy assessed with surgical exploration. Results: A total of 442 studies were included for search 1 and 8 studies for search 2. Fusion assessment throughout the literature was highly variable. Eighteen definitions and more than 250 unique fusion assessment methods were identified. The criteria that showed most consistent use were continuity of bony bridging, radiolucency around the cage, and angular motion <5°. However, reliability and accuracy studies were scarce. Conclusion: This review highlights the challenges in reaching consensus on IF assessment. The variability in IF assessment is very high, which limits the translatability of studies. Accuracy studies are needed to guide innovations of assessment. Future IF assessment strategies should focus on the standardization of computed tomography–based continuity of bony bridging. Knowledge from preclinical and imaging studies can add valuable information to this ongoing discussion. Level of Evidence: Diagnostic Level III. See Instructions for Authors for a complete description of levels of evidence.

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“…provided basic principles for species selection and practical guidelines for surgical procedures in a goat animal model. Information from this study will improve methodological rigor and documentation of future experiments [ 19 ]. Clinical examinations of scoliosis often include X-rays.…”

mentioning

confidence: 99%

2023 January issue Journal of Orthopaedic Translation

Xiao¹

2023

Journal of Orthopaedic Translation

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Preclinical model for lumbar interbody fusion in small ruminants: Rationale and guideline

Cited by 3 publications

References 61 publications

3D Printed Pedicle Screws with Microarc Oxidation Ceramic Interfaces Enhance Osteointegration and Orthopedic Fixation Feasibility

3D Printed Pedicle Screws with Microarc Oxidation Ceramic Interfaces Enhance Osteointegration and Orthopedic Fixation Feasibility

Radiologic Assessment of Interbody Fusion

2023 January issue Journal of Orthopaedic Translation

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