Preclinical mobility disability predicts incident mobility disabilityin older women

Fried, Linda P.; Bandeen‐Roche, Karen; Chaves, Paulo H.M.; Johnson, Brent A.

doi:10.1093/gerona/55.1.m43

Cited by 374 publications

(94 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Study staff members evaluated the five components of the Fried frailty assessment tool, i.e., weakness, assessed by grip strength (an average of 3 trials with the dominant hand, measured with a Jamar dynamometer), walking speed (one way for 15 feet in a straight line), unintended weight loss of Ն10 pounds in the past year, self-reported exhaustion (two Likert-type questions from the Center for Epidemiological Studies Depression [CES-D] scale [32]), and physical activity, based on the Minnesota Leisure Time Physical Activity (LTA) questionnaire (33). Grip strength was stratified by sex and body mass index, walking speed was stratified by sex and height, and physical activity scores were stratified by sex, as suggested by Fried and colleagues (31). Subjects were assigned to the nonfrail (NF) category for 0 criteria met on the Fried frailty instrument, prefrail (PF) for 1 or 2 criteria met, and frail (F) for 3 or more criteria met.…”

Section: Methodsmentioning

confidence: 99%

Preexisting Immunity, Not Frailty Phenotype, Predicts Influenza Postvaccination Titers among Older Veterans

Epps

Tumpey

Pearce

et al. 2017

Clin Vaccine Immunol

View full text Add to dashboard Cite

Both preexisting immunity to influenza and age have been shown to be correlates of influenza vaccine responses. Frailty, an indicator of functional impairment in older adults, was also shown in one study to predict lower influenza vaccine responses among nonveterans. In the current study, we aimed to determine the associations between frailty, preexisting immunity, and immune responses to influenza vaccine among older veterans. We studied 117 subjects (age range, 62 to 95 years [median age, 81 years]), divided into three cohorts based on the Fried frailty test, i.e., nonfrail (NF) (n ϭ 23 [median age, 68 years]), prefrail (n ϭ 50 [median age, 80 years]), and frail (n ϭ 44 [median age, 82 years]), during the 2010-2011 and 2011-2012 influenza seasons. Subjects received the seasonal trivalent inactivated influenza vaccine, and baseline and postvaccination samples were obtained. Anti-influenza humoral immunity, as measured by hemagglutination inhibition (HI) and microneutralization assays, was measured for influenza B, A(H1N1)pdm09, and A(H3N2) viruses. Postvaccination titers were not different between frail and NF subjects overall in this older subset of veterans. However, preexisting HI titers were strongly correlated with postvaccination titers among all functional status groups. When microneutralization titers were compared, the association between preexisting immunity and vaccine responses varied by frailty status, with the strongest correlation being observed for the NF group. In conclusion, preexisting immunity rather than frailty appeared to predict postvaccination titers in this older veteran cohort.

show abstract

Section: Methodsmentioning

confidence: 99%

Preexisting Immunity, Not Frailty Phenotype, Predicts Influenza Postvaccination Titers among Older Veterans

Epps

Tumpey

Pearce

et al. 2017

Clin Vaccine Immunol

View full text Add to dashboard Cite

show abstract

“…10,11 Consequently, the inability to walk 400 m is often used as a benchmark for identifying mobility-related disability. Self-reported walking difficulty has also been shown to predict future disability and mortality 5,12,13 and may provide complementary information to performance-based measures.…”

mentioning

confidence: 99%

What Physical Attributes Underlie Self-Reported vs. Observed Ability to Walk 400 m in Later Life?

Beauchamp

Leveille

Patel

et al. 2014

American Journal of Physical Medicine &Amp; Rehabilitation

View full text Add to dashboard Cite

Objective The aims of this study were to evaluate and contrast the physical attributes that are associated with self-reported vs. observed ability to walk 400 m among older adults. Design Analysis of baseline and 3-yr data from 1026 participants 65 yrs or older in the InCHIANTI (Invecchiare in Chianti) study was conducted. Observed and self-reported ability to walk 400 m at baseline and at 3 yrs were primary outcomes. Predictors included leg speed, leg strength, leg strength symmetry, range of motion, balance, and kyphosis. Results Balance, leg speed, leg strength, kyphosis, leg strength symmetry, and knee range of motion were associated with self-reported ability to walk 400 m at baseline (P < 0.001, c = 0.85). Balance, leg speed, and knee range of motion were associated with observed 400-m walk (P < 0.001, c = 0.85) at baseline. Prospectively, baseline leg speed and leg strength were predictive of both self-reported (P < 0.001, c = 0.79) and observed (P < 0.001, c = 0.72) ability to walk 400 m at 3 yrs. Conclusions The profiles of attributes that are associated with self-reported vs. observed walking ability differ. The factor most consistently associated with current and future walking ability is leg speed. These results draw attention to important foci for rehabilitation.

show abstract

“…11 This model has been applied to mobility outcomes using data from the Women’s Health and Aging Study II. 12 However, we believe that this study is the one of the first applications of this model to determine a potential pathway from visual impairment to mobility disability. The relationship between performance speed and incident disability that we observed mirrors results from Fried et al, adding validity to our findings.…”

Section: Discussionmentioning

confidence: 94%

“…The relationship between performance speed and incident disability that we observed mirrors results from Fried et al, adding validity to our findings. 12 …”

Section: Discussionmentioning

confidence: 99%

“…11 This WHO disability framework has been applied to mobility disability using data from the Women’s Health and Aging Study II, showing that non-disabled participants with slow walking speeds at baseline were more likely to report mobility disability 18 months later than those with moderate or fast walking speeds. 12 This result suggests that declines in mobility performance precede the report of mobility task difficulty, or mobility disability.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Does Walking Speed Mediate the Association Between Visual Impairment and Self‐Report of Mobility Disability? The Salisbury Eye Evaluation Study

Swenor

Bandeen‐Roche

Muñoz

et al. 2014

J American Geriatrics Society

View full text Add to dashboard Cite

Objectives To determine if performance speeds mediate the association between visual impairment and self-reported mobility disability over an eight-year period. Design Longitudinal analysis Setting Salisbury, MD Participants 2,520 Salisbury Eye Evaluation Study participants, age 65 years or older. Measurements Visual impairment was defined as best-corrected visual acuity worse than 20/40 in the better-seeing eye, or visual field less than 20°. Self-reported mobility disability on three tasks was assessed: walking up stairs, walking down stairs, and walking 150 feet. Performance speed on three similar tasks was measured: walking up steps (steps/second), walking down steps (steps/second), and walking 4 meters (meters/second). Results For each year of observation, the odds of reporting mobility disability was significantly greater for visually impaired than the non-visually impaired (OR difficulty walking up steps = 1.58, 95% CI: 1.32–1.89; OR difficulty walking down steps = 1.90, 95% CI: 1.59–2.28; OR difficulty walking 150 feet = 2.11, 95% CI: 1.77–2.51). Once performance speed on a similar mobility task was included in the models, the visually impaired were no longer more likely to report mobility disability than the non-visually impaired (OR difficulty walking up steps = 0.84, 95% CI: 0.65–1.11; OR difficulty walking down steps = 0.96, 95% CI: 0.74–1.24; OR difficulty walking 150 feet = 1.22, 95% CI: 0.98–1.50). Conclusion The difference in the odds of reporting mobility disability by visual impairment status is largely accounted for by slower performance speeds among the visually impaired. This suggests that visually impaired older adults walk slower and are therefore more likely to report mobility disability than the non-visually impaired. Improving mobility performance in older adults with visual impairment may minimize the perception of mobility disability.

show abstract

Preclinical mobility disability predicts incident mobility disabilityin older women

Cited by 374 publications

References 22 publications

Preexisting Immunity, Not Frailty Phenotype, Predicts Influenza Postvaccination Titers among Older Veterans

Preexisting Immunity, Not Frailty Phenotype, Predicts Influenza Postvaccination Titers among Older Veterans

What Physical Attributes Underlie Self-Reported vs. Observed Ability to Walk 400 m in Later Life?

Does Walking Speed Mediate the Association Between Visual Impairment and Self‐Report of Mobility Disability? The Salisbury Eye Evaluation Study

Contact Info

Product

Resources

About