Preclinical Hepatoprotective Effect of Herbalism Against Ethanol Induced Hepatotoxicity: A Review

Singh, Mohinder; Hussain, Talib; Firdous, Hina; Shaikh, Sibhghatulla; Rizvi, Syed Mohd Danish; Moin, Afrasim; Khan, M. Faisal; Kamal, Mohammad Amjad

doi:10.2174/1389200219666180330125003

Cited by 13 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, it is greatly significant to investigate the pathogenesis of alcoholic liver disease and develop effective treatment medicine in the treatment and prevention of alcoholic liver disease. Recently, herbal medicines have attracted increasing attention in the treatment of alcoholic liver injury, due to the wide availabilities, multitarget actions, and low side effects [ 14 – 16 ]. Chinese herbal medicines of saponins from the leaves of Panax notoginseng , Camellia nitidissima, and phenol have been used to improve the alcohol-induced liver injury [ 6 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Dendrobium officinale Flower Extraction Mitigates Alcohol‐Induced Liver Injury in Mice: Role of Antisteatosis, Antioxidative, and Anti‐Inflammatory

Sihan

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

The study aimed to evaluate the protective effect of Dendrobium officinale flower extraction (DOFE) on alcohol-induced liver injury and its probable mechanisms in mice. The chemical composition of DOFE was performed via UPLC/MS. Male Kunming mice were used to establish alcohol-induced liver injury models by oral gavage of 56% alcohol. Results showed that DOFE dramatically attenuated the increased serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), and triacylglycerol (TG). Meanwhile, hematoxylin and eosin and Oil Red O staining showed that DOFE attenuated degeneration, inflammatory infiltration, and lipid droplet accumulation. DOFE was also found to suppress the activity of malonaldehyde (MDA) and enhanced the level of glutathione (GSH) and the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in the liver. The protection of DOFE against oxidative stress was associated with the downregulation of hepatic cytochrome P450 2E1 (CYP2E1) and upregulation of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and NAD(P)H quinone oxidoreductase l (NQO1). Additionally, DOFE suppressed inflammation via downregulating Toll-like receptor-4 (TLR-4) and nuclear factor kappa-B P65 (NF-κB P65). Thus, DOFE exhibited a significant protective effect against alcohol-induced liver injury through its antisteatosis, antioxidative, and anti-inflammatory effect.

show abstract

Section: Introductionmentioning

confidence: 99%

Dendrobium officinale Flower Extraction Mitigates Alcohol‐Induced Liver Injury in Mice: Role of Antisteatosis, Antioxidative, and Anti‐Inflammatory

Sihan

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Experimental studies have shown that S. miltiorrhiza can inhibit hepatic stellate cell activity by enhancing natural killer cell functions to block liver fibrosis (82). Moreover, TCMs can protect the liver and reduce liver fibrosis by improving inflammation and reducing steatosis (83).…”

Section: Treatment Of Liver Fibrosis With Tcmmentioning

confidence: 99%

Traditional Chinese medicine, liver fibrosis, intestinal flora: is there any connection?—a narrative review

Liu¹,

Qi²,

Sun³

2021

Ann Palliat Med

View full text Add to dashboard Cite

This paper aims to analyze how intestinal flora regulates liver fibrosis pathogenesis and to evaluate the regulatory effect of traditional Chinese medicine on the intestinal flora, providing new insights into liver fibrosis treatment. Destruction of the intestinal microbiome can lead to liver fibrosis development, accelerating the intestinal microbiome's disruption. Traditional Chinese Medicine can effectively regulate the intestinal flora, helping prevent and treat liver fibrosis. This review discusses the mechanisms behind intestinal flora changes in liver fibrosis and how traditional Chinese medicine can regulate these changes.We searched PubMed, the Wanfang database, and CNKI for "liver fibrosis", "intestinal microflora", and "intestinal microbiota" and reviewed the retrieved literature. We detail the prevention and treatment options for liver fibrosis though the use of traditional Chinese medicine in regulating intestinal flora. We also highlight the influence of the intestinal flora on liver fibrosis and present the research regarding the prevention and treatment of liver fibrosis using traditional Chinese medicine. We also describe the effects of traditional Chinese medicine on the intestinal flora. Traditional Chinese medicine can effectively regulate the intestinal flora to prevent and treat liver fibrosis through the liver-intestine axis.

show abstract

“…Plowes, Geranium schiedeanum Schltdl., and Phyllanthus emblica L. are also effective in this respect (Ibrahim et al, 2015;Madrigal-Santillán et al, 2015;Chaphalkar et al, 2017). Recently a number of reviews have been published on the topic (Guan et al, 2018;Singh et al, 2018).…”

Section: Preclinical and Clinical Research Based On Ethnopharmacologimentioning

confidence: 99%

Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook

et al. 2020

View full text Add to dashboard Cite

Excessive alcohol consumption is the cause of several diseases and thus is of a major concern for society. Worldwide alcohol consumption has increased by many folds over the past decades. This urgently calls for intervention and relapse counteract measures. Modern pharmacological solutions induce complete alcohol self-restraint and prevent relapse, but they have many side effects. Natural products are most promising as they cause fewer adverse effects. Here we discuss in detail the medicinal plants used in various traditional/folklore medicine systems for targeting alcohol abuse. We also comprehensively describe preclinical and clinical studies done on some of these plants along with the possible mechanisms of action.

show abstract

Preclinical Hepatoprotective Effect of Herbalism Against Ethanol Induced Hepatotoxicity: A Review

Abstract: Accordingly, this review provides several evidences which show that these medicinal plants could be used for the treatment and prevention of ALD.

Cited by 13 publications

References 0 publications

Dendrobium officinale Flower Extraction Mitigates Alcohol‐Induced Liver Injury in Mice: Role of Antisteatosis, Antioxidative, and Anti‐Inflammatory

Dendrobium officinale Flower Extraction Mitigates Alcohol‐Induced Liver Injury in Mice: Role of Antisteatosis, Antioxidative, and Anti‐Inflammatory

Traditional Chinese medicine, liver fibrosis, intestinal flora: is there any connection?—a narrative review

Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook

Contact Info

Product

Resources

About