Preclinical evaluation of the effect of periodontal regeneration by carbonate apatite in a canine one-wall intrabony defect model

Takeuchi, Shunsuke; Fukuba, Shunsuke; Okada, Munehiro; Nohara, Kohei; Sato, Ryo; Yamaki, Daichi; Matsuura, Takanori; Hoshi, Shu; Aoki, Kazuhiro; Iwata, Takanori

doi:10.1016/j.reth.2023.01.002

Cited by 3 publications

(6 citation statements)

References 35 publications

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“…Severe adverse events were not observed thorough out the study except slight postoperative pain, rednee, and swelling at the test sites. Our findings matched the previous preclinical and clinical studies assessing the safety of CO 3 Ap granules in periodontal regenerative therapy [ [27] , [28] , [29] ].…”

Section: Discussionsupporting

confidence: 90%

“…Regarding bone regeneration, previous preclinical and clinical studies revealed that CO 3 Ap granules significantly enhanced bone regeneration like alveolar ridge preservation and guided bone regeneration [ [22] , [23] , [24] , [25] , [26] ]. However, there are limited numbers of preclinical and clinical research to evaluate the efficacy of CO 3 Ap granules for periodontal regeneration [ [27] , [28] , [29] ]. Surprisingly, there are no clinical studies assessing the efficacy of single use of CO 3 Ap granules for periodontal tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

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Clinical outcomes of periodontal regenerative therapy with carbonate apatite granules for treatments of intrabony defects, Class II and Class III furcation involvements: A 9-month prospective pilot clinical study

Fukuba,

Okada,

Iwata

2023

Regenerative Therapy

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Clinical outcomes of periodontal regenerative therapy with carbonate apatite granules for treatments of intrabony defects, Class II and Class III furcation involvements: A 9-month prospective pilot clinical study

Fukuba,

Okada,

Iwata

2023

Regenerative Therapy

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“…Six healthy beagle dogs (1‐year‐old males) were included in the sample. All surgical procedures were conducted as previously described with slight modifications 27 …”

Section: Methodsmentioning

confidence: 99%

“…To adhere to the 3R principle and minimize the overall number of animals, the right sides of the mandibles were also applied to other experimentations. After healing, one‐wall intrabony defects (5 mm in height and 4 mm in width) were made on the distal surfaces of the second premolars and the mesial of the fourth premolars in the mandible according to previous studies 27–29 . In this study, all surgical procedures were performed by a single periodontal specialist (M.O.).…”

Section: Methodsmentioning

confidence: 99%

“…After healing, one-wall intrabony defects (5 mm in height and 4 mm in width) were made on the distal surfaces of the second premolars and the mesial of the fourth premolars in the mandible according to previous studies. [27][28][29] In this study, all surgical procedures were performed by a single periodontal specialist (M.O.). A crestal incision was performed from the first premolar to the third premolar distomesially forming buccal and lingual mucoperiosteal flaps (Figure 1A-C).…”

Section: Surgical Proceduresmentioning

confidence: 99%

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Octacalcium phosphate collagen composite for periodontal regeneration in a canine one‐wall intrabony defect

Yamaki,

Fukuba,

Okada

et al. 2024

J of Periodontal Research

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ObjectiveThis study aimed to evaluate the regenerative capacities of octacalcium phosphate collagen composite (OCP/Col) in one‐wall intrabony defects in dogs. The background data discuss the present state of the field: No study has assessed the efficacy of OCP/Col for periodontal regeneration therapy despite the fact that OCP/Col has proved to be efficient for bone regeneration.MethodsIn six beagle dogs, the mandibular left third premolars were extracted 12 weeks before the experimental surgery. Standardized bone defects (5 mm in height and 4 mm in width) were simulated on the distal surface of the second premolars and mesially on the fourth premolars. The defect was filled with either OCP/Col (experimental group) or left empty (control group). Histological and histomorphometric characteristics were compared 8 weeks after surgery.ResultsNo infectious or ankylotic complications were detected at any of the tested sites. The experimental group exhibited a significantly greater volume, height, and area of newly formed bone than the control group. The former also showed a greater height of the newly formed cementum than the latter, although the results were not statistically significant. The newly formed periodontal ligaments were inserted into newly formed bone and cementum in the experimental group.ConclusionOCP/Col demonstrated high efficacy for bone and periodontal tissue regeneration that can be successfully applied for one‐wall intrabony defects.

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In vivo trial of bioresorbable mesh cages contained bone graft granules in rabbit femoral bone defects

Yanagisawa,

Hayashi,

Tsuchiya

et al. 2024

Sci Rep

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Bone graft granules implanted in bone defects come into physical contact with the host bone and form interconnected porous structure. However, there exists an accidental displacement of granules to unintended locations and leakage of granules from bone defects. Although covering the defect with a barrier membrane prevents granule emanation, this procedure is troublesome. To resolve these problems, we fabricated bioresorbable mesh cages (BRMc) in this study. Bone graft granules composed of carbonate apatite alone (Gr) and bioresorbable mesh cages (BRMc/Gr) introduced the bone graft granules and were implanted into the bone defect in the rabbit femur. Micro-computed tomography and histological analysis were conducted at 4 and 12 weeks after implantation. Osteoprogenitors in the bloodstream from the host bone passed through the pores of BRMc, penetrated the porous structure of graft granules, and might interact with individual granules. Then bone remodeling could progress actively and new bone was formed. The new bone formation was similar to the host bone at 12 weeks and there were minimal signs of local tissue inflammation. BRMc/Gr could reduce the risk of unwanted new bone formation occurring due to loss of granules from the bone defects compared with Gr because BRMc enclosed granules and prevent granules leakage from bone defects and BRMc could not induce unfavorable effects to forme new bone. Additionally, BRMc/Gr could keep granules assembled in one place, avoid displacement of granules to unintended locations, and carry easily. These results demonstrated that BRMc/Gr was effective in bone regeneration and improved clinical handling.

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Preclinical evaluation of the effect of periodontal regeneration by carbonate apatite in a canine one-wall intrabony defect model

Cited by 3 publications

References 35 publications

Clinical outcomes of periodontal regenerative therapy with carbonate apatite granules for treatments of intrabony defects, Class II and Class III furcation involvements: A 9-month prospective pilot clinical study

Clinical outcomes of periodontal regenerative therapy with carbonate apatite granules for treatments of intrabony defects, Class II and Class III furcation involvements: A 9-month prospective pilot clinical study

Octacalcium phosphate collagen composite for periodontal regeneration in a canine one‐wall intrabony defect

In vivo trial of bioresorbable mesh cages contained bone graft granules in rabbit femoral bone defects

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