Preclinical evaluation of methotrexate-loaded polyelectrolyte complexes and thermosensitive hydrogels as treatment for rheumatoid arthritis

Agostini, Sandra Barbosa Neder; Malta, Iago Henrique Silva; Rodrigues, Rafaela Figueiredo; Freitas, Jennifer Tavares Jacon; Lino, Mônica Esselin de Sousa; Santos, Rafaela Silva; Elisei, Lívia; Moraes, Thamyris Reis; Giusto, Luana Aparecida dos Reis; Oliveira, Merelym Ketterym de; Silva, Jéssica Bassi da; Bruschi, Marcos Luciano; Santos, Aline Martins dos; Nogueira, Denismar Alves; Novaes, Rômulo Dias; Pereira, Gislaine Ribeiro; Galdino, Giovane; Carvalho, Flávia Chiva

doi:10.1016/j.ejps.2021.105856

Cited by 8 publications

(3 citation statements)

References 102 publications

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“… This product provided precise control over drug release with thermosensitive properties. [103] Transdermal hydrogels loaded with DMARDs MTX The PCL- PEG-PCL triblock copolymers were synthesized with MTX-loaded nano-micelles. The hydrogels were loaded with nano-micelles releasing the MTX drug in a controlled manner across the skin layers.…”

Section: Hydrogel For Ra Treatmentmentioning

confidence: 99%

“…MTX is the most frequently used DMARDs due to its outstanding performance in improving the functionality of joints [101] . However, RA patients often overdose on MTX in their daily intake, taking 15–25 mg per week which is significantly higher than the official amount of 10 mg per week [ 102 , 103 ]. The treatment even continues for four to eight weeks or longer, reaching and surpassing the maximum tolerable dosage [102] .…”

Section: Functionalization Of Hydrogels For Ra Treatmentmentioning

confidence: 99%

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Development of biomedical hydrogels for rheumatoid arthritis treatment

Baig,

Wong,

Zia

et al. 2024

Asian Journal of Pharmaceutical Sciences

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Section: Hydrogel For Ra Treatmentmentioning

confidence: 99%

Section: Functionalization Of Hydrogels For Ra Treatmentmentioning

confidence: 99%

Development of biomedical hydrogels for rheumatoid arthritis treatment

Baig,

Wong,

Zia

et al. 2024

Asian Journal of Pharmaceutical Sciences

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“…To circumvent MTX-associated toxicities, a poloxamer-based thermosensitive hydrogel containing MTX-loaded polyelectrolyte complexes was developed. Thus, the developed poloxamer hydrogel demonstrated prolonged MTX release, and further in vivo studies in RA rats via intra-articular injection resulted in recovered cartilage damage and decreased allodynia [ 132 ]. In this way, hydrogels provided enhanced therapeutic efficacy at low doses and frequencies while circumventing drug-associated toxicity issues to provide symptomatic relief in arthritis.…”

Section: Hydrogels As Depot Delivering System For the Treatment Of Ar...mentioning

confidence: 99%

Polymeric Hydrogels for Controlled Drug Delivery to Treat Arthritis

et al. 2022

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Rheumatoid arthritis (RA) and osteoarthritis (OA) are disabling musculoskeletal disorders that affect joints and cartilage and may lead to bone degeneration. Conventional delivery of anti-arthritic agents is limited due to short intra-articular half-life and toxicities. Innovations in polymer chemistry have led to advancements in hydrogel technology, offering a versatile drug delivery platform exhibiting tissue-like properties with tunable drug loading and high residence time properties This review discusses the advantages and drawbacks of polymeric materials along with their modifications as well as their applications for fabricating hydrogels loaded with therapeutic agents (small molecule drugs, immunotherapeutic agents, and cells). Emphasis is given to the biological potentialities of hydrogel hybrid systems/micro-and nanotechnology-integrated hydrogels as promising tools. Applications for facile tuning of therapeutic drug loading, maintaining long-term release, and consequently improving therapeutic outcome and patient compliance in arthritis are detailed. This review also suggests the advantages, challenges, and future perspectives of hydrogels loaded with anti-arthritic agents with high therapeutic potential that may alter the landscape of currently available arthritis treatment modalities.

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Biomimetic and Bioinspired Intervention Strategies for the Treatment of Rheumatoid Arthritis

Han

Pang

2021

Adv Funct Materials

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Rheumatoid arthritis (RA) affects the joints and extra-articular organs and poses a significant health care problem in the modern era. Although current standard treatment modalities successfully control RA flares, no curative treatment modality for RA has been developed. Nanomedicines have addressed the drug side effects and limited efficacy of RA treatment. However, synthetic nanoparticles (NPs) can be toxic and induce immune responses in vivo, posing a risk of further RA progression. Biomimetic nanodrug delivery systems have the potential to improve the biocompatibility of synthetic NPs and the stability and targeting of pharmaceuticals in vivo. For many immune-related diseases with a complex pathogenesis and that involve a large number of different cell types, biomimetic nanodelivery systems can reduce the immunogenicity of NPs. Furthermore, some bioinspired strategies can mimic certain components of the pathological process, allowing for a more precise drug delivery and effective disease control via the carriers. This article highlights recent research on biomimetic nanodelivery systems for the treatment of RA and categorizes the design methodologies for various targets and carriers.

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Preclinical evaluation of methotrexate-loaded polyelectrolyte complexes and thermosensitive hydrogels as treatment for rheumatoid arthritis

Cited by 8 publications

References 102 publications

Development of biomedical hydrogels for rheumatoid arthritis treatment

Development of biomedical hydrogels for rheumatoid arthritis treatment

Polymeric Hydrogels for Controlled Drug Delivery to Treat Arthritis

Biomimetic and Bioinspired Intervention Strategies for the Treatment of Rheumatoid Arthritis

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