Preclinical Evaluation of a Novel Polymer-free Everolimus-eluting Stent in a Mid-term Porcine Coronary Restenosis Model

Cho, Kyung Hoon; Cho, Jeong Gwan; Park, Dae Sung; Kim, Moon-Ki; Kim, Jung-Ha; Park, Jun Kyu; Han, Xiongyi; Hyun, Dae Young; Kim, Min Chul; Sim, Doo Sun; Hong, Young Joon; Kim, Ju Han; Ahn, Youngkeun

doi:10.3346/jkms.2021.36.e259

Cited by 5 publications

(9 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was subjected to a delicate manufacturing process with laser cutting (Rofin; Starcut, Hamburg, Germany) and ultrasonic cleaning using ethanol, acetone, and distilled water. [ 8 ] Furthermore, N-TiO 2 film was deposited onto this platform using plasma-enhanced chemical vapor deposition. [ 8 , 9 ] This stent is a promising alternative to polymer-based DESs and has demonstrated good adhesion, biocompatibility, and mechanical stability.…”

Section: Discussionmentioning

confidence: 99%

“…[ 8 ] Furthermore, N-TiO 2 film was deposited onto this platform using plasma-enhanced chemical vapor deposition. [ 8 , 9 ] This stent is a promising alternative to polymer-based DESs and has demonstrated good adhesion, biocompatibility, and mechanical stability. [ 21 , 22 ] The drug release rate of the TIGEREVOLUTION stent has been shown to be comparable to that of a commercial durable-polymer everolimus-eluting stent (XIENCE Prime ® ; Abbott Vascular, Santa Clara, CA).…”

Section: Discussionmentioning

confidence: 99%

“…[ 24 ] Furthermore, we also performed an OCT-based preclinical comparative study between the TIGEREVOLUTION and XIENCE Alpine ® stents, which demonstrated comparable efficacy and safety outcomes. [ 8 ] On the basis of this preclinical evidence, the use of the TIGEREVOLUTION stent in human beings was approved by the Korean Food and Drug Administration on July 31, 2020. This case report is the first to describe the implantation of a TIGEREVOLUTION stent in the human coronary artery.…”

Section: Discussionmentioning

confidence: 99%

“…[ 8 , 9 ] By using this technique, we also invented a novel polymer-free everolimus-eluting stent with nitrogen-doped TiO 2 (N-TiO 2 ) film, named the TIGEREVOLUTION ® stent. [ 8 , 9 ]…”

Section: Introductionmentioning

confidence: 99%

“…[8,9] By using this technique, we also invented a novel polymer-free everolimus-eluting stent with nitrogen-doped TiO 2 (N-TiO 2 ) film, named the TIGEREVOLUTION ® stent. [8,9] We herein report a case of successful implantation of the TIGEREVOLUTION stent.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Successful implantation of a novel polymer-free everolimus-eluting stent using nitrogen-doped titanium dioxide film with good patency on follow-up angiography: A case report

Jeong

Park

et al. 2022

Medicine

Self Cite

View full text Add to dashboard Cite

Rationale: Despite technological advances in interventional cardiology during the last decades, many concerns remain regarding the narrowing and occlusion of the in-stent area. Particularly, polymer materials pose several problems, including chronic arterial inflammation, impaired arterial healing, and stent thrombosis. To avoid these complications, we invented the TIGEREVOLUTION stent with a cobalt–chromium alloy-based stent platform deposited with N-TiO2 film, which has demonstrated good biocompatibility. As this stent is not coated with polymer, it is expected to have decreased risk of stent thrombosis. Patient concerns: A 62-year-old Korean man visited our department because of angina. We commenced coronary angiography (CAG). Diagnosis: CAG revealed critical stenosis in the mid-portion of the right coronary artery, with a minimum lumen area of 1.08mm2 on optical coherence tomography (OCT). Intervention: Percutaneous coronary intervention was performed with implantation of a novel 3.5 × 26-mm polymer-free everolimus-eluting stent using nitrogen-doped titanium dioxide film (TIGEREVOLUTION® stent). Post-percutaneous coronary intervention OCT showed good stent expansion and apposition, and the patient was discharged successfully and uneventfully. Outcomes: Eight months later, follow-up coronary angiography demonstrated good stent patency with no definitive evidence of in-stent restenosis, with thin stent strut coverage demonstrated on OCT. Lessons: We report the first case of TIGEREVOLUTION stent implantation with follow-up OCT at 8 months.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…[ 8 , 9 ] By using this technique, we also invented a novel polymer-free everolimus-eluting stent with nitrogen-doped TiO 2 (N-TiO 2 ) film, named the TIGEREVOLUTION ® stent. [ 8 , 9 ]…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Successful implantation of a novel polymer-free everolimus-eluting stent using nitrogen-doped titanium dioxide film with good patency on follow-up angiography: A case report

Jeong

Park

et al. 2022

Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

Preliminary Investigation on Efficacy and Safety of Substance P-Coated Stent for Promoting Re-Endothelialization: A Porcine Coronary Artery Restenosis Model

Park,

Oh,

Jin

et al. 2023

Tissue Eng Regen Med

View full text Add to dashboard Cite

Drug-Eluting, Bioresorbable Cardiovascular Stents─Challenges and Perspectives

Vallejo-Zamora

Vega-Cantú

Rodrı́guez

et al. 2022

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Globally, the leading causes of natural death are attributed to coronary heart disease and type 1 and type 2 diabetes. High blood pressure levels, high cholesterol levels, smoking, and poor eating habits lead to the agglomeration of plaque in the arteries, reducing the blood flow. The implantation of devices used to unclog vessels, known as stents, sometimes results in a lack of irrigation due to the excessive proliferation of endothelial tissue within the blood vessels and is known as restenosis. The use of drug-eluting stents (DESs) to deliver antiproliferative drugs has led to the development of different encapsulation techniques. However, due to the potency of the drugs used in the initial stent designs, a chronic inflammatory reaction of the arterial wall known as thrombosis can cause a myocardial infarction (MI). One of the most promising drugs to reduce this risk is everolimus, which can be encapsulated in lipid systems for controlled release directly into the artery. This review aims to discuss the current status of stent design, fabrication, and functionalization. Variables such as the mechanical properties, metals and their alloys, drug encapsulation and controlled elution, and stent degradation are also addressed. Additionally, this review covers the use of polymeric surface coatings on stents and the recent advances in layer-by-layer coating and drug delivery. The advances in nanoencapsulation techniques such as liposomes and micro- and nanoemulsions and their functionalization in bioresorbable, drug-eluting stents are also highlighted.

show abstract

Preclinical Evaluation of a Novel Polymer-free Everolimus-eluting Stent in a Mid-term Porcine Coronary Restenosis Model

Cited by 5 publications

References 32 publications

Successful implantation of a novel polymer-free everolimus-eluting stent using nitrogen-doped titanium dioxide film with good patency on follow-up angiography: A case report

Successful implantation of a novel polymer-free everolimus-eluting stent using nitrogen-doped titanium dioxide film with good patency on follow-up angiography: A case report

Preliminary Investigation on Efficacy and Safety of Substance P-Coated Stent for Promoting Re-Endothelialization: A Porcine Coronary Artery Restenosis Model

Drug-Eluting, Bioresorbable Cardiovascular Stents─Challenges and Perspectives

Contact Info

Product

Resources

About