Abstract:A new chemical entity must demonstrate efficacy and safety in order to be considered a successful therapeutic agent. Towards that goal, it is best to discover drugs demonstrating a wide concentration range between (lower) preclinical efficacious plasma concentrations and (higher) plasma concentrations eliciting preclinical off-target adverse effects. Drugs possessing such characteristics provide greater flexibility in clinical trials and explorations into alternative indications. Thus, preclinical studies rela… Show more
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