Abstract:Acute lymphoblastic leukemia (ALL) is a disease of the bone marrow (BM) microenvironment, in which ALL-stroma interactions, signaling molecules, and low oxygen tension all contribute to leukemia development and maintenance. The cytokine interleukin 12 (IL12) is a key primer of the initial specific T-cell immune response for resisting cancer progression, however its potential as an anti-leukemia immunotherapeutic agent has been largely under-examined. One potential reason for this oversight is the inability of … Show more
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