2017
DOI: 10.5599/admet.5.4.437
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Preclinical assessment of ulixertinib, a novel ERK1/2 inhibitor

Abstract: <p class="ADMETabstracttext">Ulixertinib (BVD-523) is a novel and selective reversible inhibitor of ERK1/ERK2. In xenograft studies it inhibited tumor growth in BRAF-mutant melanoma and colorectal xenografts as well as KRAS-mutant colorectal and pancreatic models. Ulixertinib is currently in Phase I clinical development for the treatment of advance solid tumors. The objective of the study is to assess the metabolic stability (in various pre-clinical and human liver microsomes/hepatocytes), permea… Show more

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