Preclinical assessment of MAGMAS inhibitor as a potential therapy for pediatric medulloblastoma
Zahra Motahari,
Javier J. Lepe,
Malia R. Bautista
et al.
Abstract:Medulloblastoma, the most common pediatric brain malignancy, has Sonic Hedgehog (SHH) and non-SHH group3 subtypes. MAGMAS (Mitochondrial Associated Granulocyte Macrophage colony-stimulating factor Signaling molecules) encode for mitochondrial import inner membrane translocase subunit and is responsible for translocation of matrix proteins across the inner membrane. We previously reported that a small molecule MAGMAS inhibitor, BT9, decreases cell proliferation, migration, and oxidative phosphorylation in adult… Show more
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