Preclinical Assessment of a Zwitterionic Tantalum Oxide Nanoparticle X-ray Contrast Agent

Bonitatibus, Peter J.; Torres, Andrew S.; Kandapallil, Binil; Lee, Brian D.; Goddard, Greg D.; Colborn, Robert E.; Marino, Michael

doi:10.1021/nn300928g

Cited by 73 publications

(76 citation statements)

References 41 publications

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“…These important considerations are beyond the scope of tantalum clearly merits further consideration. Results published to date suggest that some tantalum oxide nanoparticles have physicochemical and biological characteristics that make them attractive for use as intravascular CT contrast agents (16,19,21,22). These water-soluble agents can be formulated at concentrations required for CT and radiography and are well tolerated at high doses.…”

Section: Contrast Media: Ct Image Contrast Of High-z Elements: Phantomentioning

confidence: 99%

CT Image Contrast of High-ZElements: Phantom Imaging Studies and Clinical Implications

Fitzgerald¹,

Colborn²,

Edic³

et al. 2016

Radiology

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Purpose:To quantify the computed tomographic (CT) image contrast produced by potentially useful contrast material elements in clinically relevant imaging conditions. Materials and Methods:Equal mass concentrations (grams of active element per milliliter of solution) of seven radiodense elements, including iodine, barium, gadolinium, tantalum, ytterbium, gold, and bismuth, were formulated as compounds in aqueous solutions. The compounds were chosen such that the active element dominated the x-ray attenuation of the solution. The solutions were imaged within a modified 32-cm CT dose index phantom at 80, 100, 120, and 140 kVp at CT. To simulate larger body sizes, 0.2-, 0.5-, and 1.0-mmthick copper filters were applied. CT image contrast was measured and corrected for measured concentrations and presence of chlorine in some compounds. Results:Each element tested provided higher image contrast than iodine at some tube potential levels. Over the range of tube potentials that are clinically practical for averagesized and larger adults-that is, 100 kVp and higher-barium, gadolinium, ytterbium, and tantalum provided consistently increased image contrast compared with iodine, respectively demonstrating 39%, 56%, 34%, and 24% increases at 100 kVp; 39%, 66%, 53%, and 46% increases at 120 kVp; and 40%, 72%, 65%, and 60% increases at 140 kVp, with no added x-ray filter. Conclusion:The consistently high image contrast produced with 100-140 kVp by tantalum compared with bismuth and iodine at equal mass concentration suggests that tantalum could potentially be favorable for use as a clinical CT contrast agent.q RSNA, 2015

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Section: Contrast Media: Ct Image Contrast Of High-z Elements: Phantomentioning

confidence: 99%

CT Image Contrast of High-ZElements: Phantom Imaging Studies and Clinical Implications

Fitzgerald¹,

Colborn²,

Edic³

et al. 2016

Radiology

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“…[ 135 ] Moreover, this research demonstrated that the mixed-charge zwitterionic surfaces on NPs can also be constructed from other types of ligands besides alkanethiols. So it promises to surface modify various types of NPs with mixed-charge monolayers by using the corresponding ligands that have end groups can conjugate with NPs.…”

Section: Stabilization Of Nps With Mixed-charge Monolayersmentioning

confidence: 83%

“…Previously, a assessment of zwitterionic tantalum oxide nanoparticles in vivo showed that the small 5 nm mixed-charge siloxanes coated nanoparticles have much lower retention in liver, spleen and kidney than the non-zwitterionic diethylphosphatoethyl-derivatized siloxane coated nanoparticles. [ 135 ] What's more, these tantalum oxide nanoparticles with the mixed-charge zwitterionic coating did not induce pathological responses in the kidneys due to effi cient renal clearance, which makes them very promising as novel X-ray contrast media. Importantly, the mixed-charge AuNPs showed higher accumulation and slower clearance in tumors than PEGylated AuNPs do for times of 24-72 h (Figure 7 D).…”

Section: Nonfouling Mixed-charge Nps In Vitro and In Vivomentioning

confidence: 99%

Surface Tailoring of Nanoparticles via Mixed‐Charge Monolayers and Their Biomedical Applications

Liu

Jin

et al. 2014

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The recent convergence of nanomaterials and medicine has provided an expanding horizon for people to achieve encouraging advances in many biomedical applications such as cancer diagnosis and therapy. However, to realize desirable functions in the rather complex biological systems, a suitable surface coating is greatly in need for nanoparticles (NPs), regardless of the species. In this review, a recently developed surface modification strategy is highlighted--mixed-charge monolayers--with an emphasis on the nanointerfaces of inorganic NPs. Two typical mixed-charge gold NPs (AuNPs) prepared from surface modifications with different combinations of oppositely charged alkanethiols are shown as detailed examples to discuss how the mixed-charge monolayer can help NPs meet the criteria for in vitro and in vivo biomedical applications, including those critical issues like colloidal stability, nonfouling properties, and smart responses (pH-sensitivity) for tumor targeting.

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“…26 Preclinical murine data has shown superior imaging performance, encouraging physicochemical properties, and low retention levels. 22,24 Although the biological properties of tungsten are less well understood, tungsten agents have also been identified as potential CT contrast agents and were used in preclinical DECT imaging. 23,32 Other high-Z elements with potential as possible CT contrast agents include gold, 33,34 ytterbium, 35 and gadolinium.…”

Section: Discussionmentioning

confidence: 99%

“…The aim of this study was to evaluate a representative selection (Table 1) of conventional and novel CT contrast elements either in development [22][23][24][25] or in routine clinical use. The nearthreefold difference in k edge energy between different elements was anticipated to result in widely varying attenuation profiles over the 40 to 140 keV range.…”

Section: Introductionmentioning

confidence: 99%

Complementary contrast media for metal artifact reduction in dual-energy computed tomography

et al. 2015

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Abstract. Metal artifacts have been a problem associated with computed tomography (CT) since its introduction. Recent techniques to mitigate this problem have included utilization of high-energy (keV) virtual monochromatic spectral (VMS) images, produced via dual-energy CT (DECT). A problem with these high-keV images is that contrast enhancement provided by all commercially available contrast media is severely reduced. Contrast agents based on higher atomic number elements can maintain contrast at the higher energy levels where artifacts are reduced. This study evaluated three such candidate elements: bismuth, tantalum, and tungsten, as well as two conventional contrast elements: iodine and barium. A water-based phantom with vials containing these five elements in solution, as well as different artifact-producing metal structures, was scanned with a DECT scanner capable of rapid operating voltage switching. In the VMS datasets, substantial reductions in the contrast were observed for iodine and barium, which suffered from contrast reductions of 97% and 91%, respectively, at 140 versus 40 keV. In comparison under the same conditions, the candidate agents demonstrated contrast enhancement reductions of only 20%, 29%, and 32% for tungsten, tantalum, and bismuth, respectively. At 140 versus 40 keV, metal artifact severity was reduced by 57% to 85% depending on the phantom configuration.

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Preclinical Assessment of a Zwitterionic Tantalum Oxide Nanoparticle X-ray Contrast Agent

Cited by 73 publications

References 41 publications

CT Image Contrast of High-ZElements: Phantom Imaging Studies and Clinical Implications

CT Image Contrast of High-ZElements: Phantom Imaging Studies and Clinical Implications

Surface Tailoring of Nanoparticles via Mixed‐Charge Monolayers and Their Biomedical Applications

Complementary contrast media for metal artifact reduction in dual-energy computed tomography

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