Precision sampling fuels precision oncology: an evolutionary perspective

Manini, Claudia; López-Fernández, Estíbaliz; López, José I.

doi:10.1016/j.trecan.2021.08.006

Cited by 5 publications

(1 citation statement)

References 15 publications

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“…In addition, CCRCC is a quite common neoplasm in daily practice and a well-known example of intratumor heterogeneity (ITH). The following paragraphs review the principal arguments supporting the necessity to update tumor sampling strategies and revisit possible alternatives for the progressive implementation of a so-called “precision sampling” [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Towards Personalized Sampling in Clear Cell Renal Cell Carcinomas

Manini

López-Fernández

López

2022

Cancers

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Intratumor heterogeneity (ITH) is a constant evolutionary event in all malignant tumors, and clear cell renal cell carcinoma (CCRCC) is a paradigmatic example. ITH is responsible for most therapeutic failures in the era of precision oncology, so its precise detection remains a must in modern medicine. Unfortunately, classic sampling protocols do not resolve the problem as expected and several strategies have been being implemented in recent years to improve such detection. Basically, multisite tumor sampling (MSTS) and the homogenization of the residual tumor tissue are on display. A next step of the MSTS strategy considering the recently discovered patterns of ITH regionalization is presented here, the so-called personalized MSTS (pMSTS). This modification consists of paying more attention to sample the tumor periphery since it is this area with maximum levels of ITH.

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Section: Introductionmentioning

confidence: 99%