Precision pinch force control via brain and spinal motor neuron excitability during motor imagery

Fukumoto, Yuki; Todo, Mitsugu; Bizen, Hiroki; Kimura, Daisuke; Suzuki, Toshiaki

doi:10.1016/j.neulet.2021.135843

Cited by 8 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Second, only a few reports have focused on spinal motor neuron excitability during KMI. In previous studies that simultaneously assessed brain activity, spinal motor neuron excitability, and precision pinch force control skills, changes in spinal motor neuron excitability, but not brain activity, were most strongly associated with precision pinch force control skills 20 . Spinal motor neuron is important as the final common pathway for motor commands, which are directly related to motor expression.…”

Section: Introductionmentioning

confidence: 78%

“…The sample size was calculated to be 12. The sample size estimation considered the possibility of high effect sizes in this study because our previous studies 20,38 showed a high effect size; therefore, an appropriate sample size was necessary to prevent error. Therefore, 21 healthy participants (13 men and 8 women; mean age: 24.8 ± 5.5 years) were included to ensure that the actual sample size was greater than the calculated sample size.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Differences in motor imagery strategy change behavioral outcome

Fukumoto

Todo²,

Bunno³

et al. 2022

Sci Rep

Self Cite

View full text Add to dashboard Cite

Kinesthetic motor imagery (KMI) involves imagining the feeling and experience of movements. We examined the effects of KMI, number visualizing, and KMI with number visualizing on the excitability of spinal motor neurons and a behavioral outcome measure in a pinch force task. Healthy participants (13 men and 8 women; mean age: 24.8 ± 5.5 years) were recruited. We compared the F-waves of the left thenar muscles after stimulating the left median nerve at the wrist during each motor imagery condition after a practice session. The KMI condition consisted of imagining muscle contraction, the number visualizing condition consisted of imagining the pinch force increasing numerically, and the KMI with number visualizing consisted of alternating between the KMI and imagining the pinch force increasing numerically. Before and after motor imagery, the time required to adjust to the target pinch force was compared. The time required to adjust the pinch force was shorter in the KMI with number visualizing condition than in the KMI and number visualizing conditions. There was no difference in the F/M amplitude ratio between each MI strategy condition, indicating the excitability of spinal motor neurons. Numerical information helped to improve the ability of participants to perform KMI.

show abstract

Section: Introductionmentioning

confidence: 78%

Section: Methodsmentioning

confidence: 99%

Differences in motor imagery strategy change behavioral outcome

Fukumoto

Todo²,

Bunno³

et al. 2022

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…From Table 1, it can be noticed that in The large difference between WT and HOM found in SN could be attributed to Krabbe disease, which is characterized by a profound neurodegeneration and demyelination of nerve tissue [30]. In fact, the classes most represented in the myelin sheaths (HexCer, SHexCer, PC, PE-O) are those most decreased in the SN of HOM [28].…”

Section: Within-class Comparison Of Lipid Profiles Of Diseased and He...mentioning

confidence: 99%

Untargeted Lipidomic Approach for Studying Different Nervous System Tissues of the Murine Model of Krabbe Disease

Alabed,

Del Grosso,

Bellani

et al. 2023

Biomolecules

View full text Add to dashboard Cite

Krabbe disease is a rare neurodegenerative disease with an autosomal recessive character caused by a mutation in the GALC gene. The mutation leads to an accumulation of psychosine and a subsequent degeneration of oligodendrocytes and Schwann cells. Psychosine is the main biomarker of the disease. The Twitcher mouse is the most commonly used animal model to study Krabbe disease. Although there are many references to this model in the literature, the lipidomic study of nervous system tissues in the Twitcher model has received little attention. This study focuses on the comparison of the lipid profiles of four nervous system tissues (brain, cerebellum, spinal cord, and sciatic nerve) in the Twitcher mouse compared to the wild-type mouse. Altogether, approximately 230 molecular species belonging to 19 lipid classes were annotated and quantified. A comparison at the levels of class, molecular species, and lipid building blocks showed significant differences between the two groups, particularly in the sciatic nerve. The in-depth study of the lipid phenotype made it possible to hypothesize the genes and enzymes involved in the changes. The integration of metabolic data with genetic data may be useful from a systems biology perspective to gain a better understanding of the molecular basis of the disease.

show abstract

“…The error in exerting a 10% MVC pinch force for 10 s was used as an index of fingertip dexterity (Fukumoto et al 2016(Fukumoto et al , 2021 because elderly participants have difficulty in exerting a stable amount of force of approximately 10% MVC during isometric contractions (Griffin et al 2009). Visual feedback was provided by the numeric value of pinch force (kgf) displayed on a monitor.…”

Section: Evaluation Of Fingertip Dexteritymentioning

confidence: 99%

Decreased nerve conduction velocity may be a predictor of fingertip dexterity and subjective complaints

et al. 2023

Self Cite

View full text Add to dashboard Cite

We examined the causes of decreased fingertip dexterity in elderly individuals with an aim to improve their quality of life by improving their activities of daily living. We calculated nerve conduction velocity, absolute error during force adjustment tasks, and fingertip dexterity test scores for 30 young (21–34 years old) and 30 elderly (60–74 years old) participants to identify age-related changes. We also assessed subjective complaints of pain, motor function, and numbness. Motor nerve (young: 55.8 ± 3.7 m/s; elderly: 52.2 ± 5.0 m/s) and sensory nerve (young: 59.4 ± 3.4 m/s; elderly: 55.5 ± 5.3 m/s) conduction velocities decreased in an age-dependent manner. Moreover, the decrease of motor nerve conduction velocity was associated with decreased fingertip dexterity (objective index), while the decrease of sensory nerve conduction velocity was associated with subjective complaints of pain and motor function (subjective index).

show abstract

Precision pinch force control via brain and spinal motor neuron excitability during motor imagery

Cited by 8 publications

References 23 publications

Differences in motor imagery strategy change behavioral outcome

Differences in motor imagery strategy change behavioral outcome

Untargeted Lipidomic Approach for Studying Different Nervous System Tissues of the Murine Model of Krabbe Disease

Decreased nerve conduction velocity may be a predictor of fingertip dexterity and subjective complaints

Contact Info

Product

Resources

About