Precision of MRI radiomics features in the liver and hepatocellular carcinoma

Carbonell, Guillermo; Kennedy, Paul; Bane, Octavia; Kirmani, Ammar; Homsi, Maria El; Stocker, Daniel; Said, Daniela; Mukherjee, Pritam; Gevaert, Olivier; Lewis, Sara; Hectors, Stefanie; Taouli, Bachir

doi:10.1007/s00330-021-08282-1

Cited by 24 publications

(18 citation statements)

References 38 publications

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“…Of note, one study showed that intra-reader tumoral and peritumoral reproducibility were greatest in MRI[ 88 ]. Another study showed that for test-retest (same MRI system, 2 different MRI exams), the intraclass correlation coefficient varied from 0.53-0.99 and the inter-platform reproducibility (MRI systems from 2 different vendors) varied from 0.58-0.99[ 89 ]. Regarding different contrast phases, Ibrahim et al [ 90 ] showed that 25% of extracted features had a concordance correlation coefficient (CCC) > 0.9 across arterial and portal venous phases.…”

Section: Radiomics Reproducibility In Hccmentioning

confidence: 99%

Current status and future perspectives of radiomics in hepatocellular carcinoma

Miranda¹,

Horvat²,

Fonseca³

et al. 2023

World J Gastroenterol

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Given the frequent co-existence of an aggressive tumor and underlying chronic liver disease, the management of hepatocellular carcinoma (HCC) patients requires experienced multidisciplinary team discussion. Moreover, imaging plays a key role in the diagnosis, staging, restaging, and surveillance of HCC. Currently, imaging assessment of HCC entails the assessment of qualitative characteristics which are prone to inter-reader variability. Radiomics is an emerging field that extracts high-dimensional mineable quantitative features that cannot be assessed visually with the naked eye from medical imaging. The main potential applications of radiomic models in HCC are to predict histology, response to treatment, genetic signature, recurrence, and survival. Despite the encouraging results to date, there are challenges and limitations that need to be overcome before radiomics implementation in clinical practice. The purpose of this article is to review the main concepts and challenges pertaining to radiomics, and to review recent studies and potential applications of radiomics in HCC.

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Section: Radiomics Reproducibility In Hccmentioning

confidence: 99%

Current status and future perspectives of radiomics in hepatocellular carcinoma

Miranda¹,

Horvat²,

Fonseca³

et al. 2023

World J Gastroenterol

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“…Primary liver cancer is the second most common cause of cancer mortality worldwide and the sixth most common cancer overall [398]. MRI is superior to CT in sensitivity, specificity, and accuracy [399] and can be used to determine the differential diagnosis [400][401][402], variant analysis [403], arterial phase hyperenhancement [404], small precursor and recurrent lesions [405,406], liver perfusion [407], histological grade, microvascular invasion status, local and systemic therapeutic responses, prognosis [408,409], and as a preoperative marker [410] in hepatocellular carcinoma patients. PET/MRI imaging is also used for the diagnosis of patients with hepatocellular carcinoma [411][412][413], whereas multi-phasic MRI staging was found to be more accurate than the straight hepatocellular carcinomagrading approach [414].…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%

Magnetic Fields and Cancer: Epidemiology, Cellular Biology, and Theranostics

Maffei

2022

IJMS

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Humans are exposed to a complex mix of man-made electric and magnetic fields (MFs) at many different frequencies, at home and at work. Epidemiological studies indicate that there is a positive relationship between residential/domestic and occupational exposure to extremely low frequency electromagnetic fields and some types of cancer, although some other studies indicate no relationship. In this review, after an introduction on the MF definition and a description of natural/anthropogenic sources, the epidemiology of residential/domestic and occupational exposure to MFs and cancer is reviewed, with reference to leukemia, brain, and breast cancer. The in vivo and in vitro effects of MFs on cancer are reviewed considering both human and animal cells, with particular reference to the involvement of reactive oxygen species (ROS). MF application on cancer diagnostic and therapy (theranostic) are also reviewed by describing the use of different magnetic resonance imaging (MRI) applications for the detection of several cancers. Finally, the use of magnetic nanoparticles is described in terms of treatment of cancer by nanomedical applications for the precise delivery of anticancer drugs, nanosurgery by magnetomechanic methods, and selective killing of cancer cells by magnetic hyperthermia. The supplementary tables provide quantitative data and methodologies in epidemiological and cell biology studies. Although scientists do not generally agree that there is a cause-effect relationship between exposure to MF and cancer, MFs might not be the direct cause of cancer but may contribute to produce ROS and generate oxidative stress, which could trigger or enhance the expression of oncogenes.

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“…This may be related to the overall tendency to perform and publish explorative radiomics studies based on the novelty of the topic rather than to improve the strict methodology and workflow of radiomics analysis [ 52 , 58 ]. Standardization of the acquisition protocols in liver imaging is a fundamental effort in order to minimize the variability of radiomics features across centers and scanners [ 59 ]. Furthermore, the International Biomarker Standardization Initiative (IBSI) is working toward standardization of extraction of quantitative features extracted from medical images and it already provided reference values for radiomics features on CT [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

Systematic review with radiomics quality score of cholangiocarcinoma: an EuSoMII Radiomics Auditing Group Initiative

et al. 2023

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Objectives To systematically review current research applications of radiomics in patients with cholangiocarcinoma and to assess the quality of CT and MRI radiomics studies. Methods A systematic search was conducted on PubMed/Medline, Web of Science, and Scopus databases to identify original studies assessing radiomics of cholangiocarcinoma on CT and/or MRI. Three readers with different experience levels independently assessed quality of the studies using the radiomics quality score (RQS). Subgroup analyses were performed according to journal type, year of publication, quartile and impact factor (from the Journal Citation Report database), type of cholangiocarcinoma, imaging modality, and number of patients. Results A total of 38 original studies including 6242 patients (median 134 patients) were selected. The median RQS was 9 (corresponding to 25.0% of the total RQS; IQR 1–13) for reader 1, 8 (22.2%, IQR 3–12) for reader 2, and 10 (27.8%; IQR 5–14) for reader 3. The inter-reader agreement was good with an ICC of 0.75 (95% CI 0.62–0.85) for the total RQS. All studies were retrospective and none of them had phantom assessment, imaging at multiple time points, nor performed cost-effectiveness analysis. The RQS was significantly higher in studies published in journals with impact factor > 4 (median 11 vs. 4, p = 0.048 for reader 1) and including more than 100 patients (median 11.5 vs. 0.5, p < 0.001 for reader 1). Conclusions Quality of radiomics studies on cholangiocarcinoma is insufficient based on the radiomics quality score. Future research should consider prospective studies with a standardized methodology, validation in multi-institutional external cohorts, and open science data.

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Precision of MRI radiomics features in the liver and hepatocellular carcinoma

Cited by 24 publications

References 38 publications

Current status and future perspectives of radiomics in hepatocellular carcinoma

Current status and future perspectives of radiomics in hepatocellular carcinoma

Magnetic Fields and Cancer: Epidemiology, Cellular Biology, and Theranostics

Systematic review with radiomics quality score of cholangiocarcinoma: an EuSoMII Radiomics Auditing Group Initiative

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