Precision of Cell Density Estimates and Endothelial Cell Loss With Age

Cheng, H; Jacobs, P; McPherson, Klim; Noble, Mark J.

doi:10.1001/archopht.1985.01050100054017

Cited by 80 publications

(40 citation statements)

References 22 publications

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“…They did not perform regional specular microscopy in the area of the tube. In our study, we found a mean endothelial cell loss of approximatively 8% for the central and peripheral cornea during a 6-month period after surgery, which is higher than the reported age-related endothelial cell loss, 15 but comparable or even less to that following cataract extraction 16,17 or other glaucoma filtering procedures. 6,7,18 Smith et al 6 calculated a mean central endothelial cell loss ranging from 1.6 to 54.8% three months after glaucoma surgery, correlated with postoperative AC depth and intraoperative corneal touch.…”

Section: Discussionmentioning

confidence: 48%

Coupling of HRT II and AS-OCT to evaluate corneal endothelial cell loss and in vivo visualization of the Ahmed glaucoma valve implant

Mendrinos

Dosso

Sommerhalder

et al. 2008

Eye

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Section: Discussionmentioning

confidence: 48%

Coupling of HRT II and AS-OCT to evaluate corneal endothelial cell loss and in vivo visualization of the Ahmed glaucoma valve implant

Mendrinos

Dosso

Sommerhalder

et al. 2008

Eye

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“…However, this destruction of the endothelial cells continues further after surgery. The number of endothelial cells decreases by 0.9–1% per annum even in healthy corneas without any intervention [2]. After cataract surgery, it has been shown that endothelial cell density continues to decrease beyond 3 months, at least for a year, although the rate of loss decreases with time, being about 10% during the first year [3].…”

Section: Introductionsupporting

confidence: 39%

Complement Activation in the Aqueous Humor of Pseudophakic Bullous Keratopathy Patients

et al. 2012

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Background/Aims: According to some studies, inflammation is a potential etiological factor in pseudophakic bullous keratopathy (PBK). Our aim was to obtain information on the activation of the complement system in the aqueous humor in this disorder. Methods: Aqueous humor samples were collected during keratoplasty of 12 PBK patients, as well as during phacoemulsification surgery of 18 control patients. The concentrations of the protein-protein complexes generated during complement activation (C1rC1sC1inh and C3bBbP) through the classical and alternative pathways, respectively, as well as of the C3 cleavage product C3a, were measured with ELISA methods. The correlation among the complement factors and between the duration of the edema, the stage of the disease, and the level of the complement activation products was examined. Results: The concentration of C1rC1sC1inh, C3bBbP complex and C3a was significantly higher in the PBK group (p < 0.001) compared to the control group. In PBK patients, a correlation was found between the levels of the C1rC1sC1inh complex and C3a only. Conclusion: Our new findings indicate that in PBK the complement system is activated – via the classical pathway – in the aqueous humor. The activated complement may play a role in increased endothelial cell loss.

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“…It is well established that there is a gradual decrease in endothelial cell density (ECD) and a corresponding increase in polymegathism and pleomorphism with advancing age. 1,[3][4][5][6][7][8][9] Clinically, the assessment of ECD and morphology can provide valuable information in relation to the functional reserve of the corneal endothelium.…”

Section: Introductionmentioning

confidence: 99%

Identifying relationships between tomography-derived corneal thickness, curvature, and diameter and in vivo confocal microscopic assessment of the endothelium in healthy corneas of young adults

Patel

McGhee

2008

Eye

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Purpose Despite the importance of a healthy endothelial layer in anterior segment surgery, the possible influence of corneal parameters on endothelial cell density (ECD) has largely been ignored in the young adult eye. This study investigated the possible associations between corneal tomographic parameters and ECD values in young adults. Methods Subjects aged 21-30 years, with normal corneas were recruited. Mean ECD, mean cell area (MCA), coefficient of variation for cell area (COVA), and proportion of hexagonal cells were derived by in vivo confocal microscopy. The Orbscan II system was used to measure corneal parameters including: thickness, horizontal corneal diameter, corneal curvature, anterior and posterior elevation, and eccentricity. Results Sixty-two subjects (42 female, 20 male) were included (mean age 25±3 years). Overall mean ECD was 3169±309 cells/mm 2 with no differences between genders. Mean percentage of hexagonality was 53 ± 5%, male subjects (55%) had a higher percentage of hexagonal cells than female subjects (51%) (P ¼ 0.02). Central corneal thickness (CCT) was 529±43 lm. Central ECD was significantly correlated with CCT (Pearson's r ¼ 0.26, P ¼ 0.04). However, horizontal corneal diameter (r ¼ 0.19, P ¼ 0.14), anterior corneal curvature (r ¼ À0.07, P ¼ 0.6), and posterior corneal curvature (r ¼ À0.07, P ¼ 0.6) were not correlated with ECD or percentage of hexagonality. There was no statistically significant association between anterior chamber depth (3.6±0.3 mm) and ECD (r ¼ 0.15, P ¼ 0.3). Conclusion Corneal thickness is related to ECD in normal young adult eye, with lower ECD values identified in thinner corneas; however, corneal diameter and corneal curvature do not have a significant correlation with ECD.

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Precision of Cell Density Estimates and Endothelial Cell Loss With Age

Cited by 80 publications

References 22 publications

Coupling of HRT II and AS-OCT to evaluate corneal endothelial cell loss and in vivo visualization of the Ahmed glaucoma valve implant

Coupling of HRT II and AS-OCT to evaluate corneal endothelial cell loss and in vivo visualization of the Ahmed glaucoma valve implant

Complement Activation in the Aqueous Humor of Pseudophakic Bullous Keratopathy Patients

Identifying relationships between tomography-derived corneal thickness, curvature, and diameter and in vivo confocal microscopic assessment of the endothelium in healthy corneas of young adults

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