Precision medicine: Vinpocetine as a potential treatment for GABRG2‐related epilepsy

Abstract

GABRG2 encodes the inhibitory GABAA (γ-aminobutyric acid type A) receptor γ2 subunit. GABAA receptors are the major mediators of fast inhibitory synaptic transmission in the central nervous system. The GABAA receptor belongs to a superfamily of ligand-gated ion channels, the majority containing two α subunits, two β subunits, and a γ or δ subunit. 1 GABRG2 pathogenic variants are associated with generalized epileptic syndromes, varying from simple febrile seizures and childhood absence epilepsy to more severe refractory phenotypes. [2][3][4] Vinpocetine, a synthetic vinca alkaloid derivative, has anti-inflammatory properties and the ability to inhibit