Precision medicine and theranostics using radiopharmaceuticals in oncology

Beek, Erik T. te; Teunissen, Jaap J.M.; Postema, Jan W A; Lafeber, Albert; Broek, Marc R J Ten

doi:10.1111/bcp.14942

Cited by 11 publications

(3 citation statements)

References 15 publications

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“…The term, theranostics literally means a combination of diagnosis and therapeutics and refers to the pairing of diagnostic methods such as the proteogenomics approach to biomarker discovery, with appropriate therapeutic interventions for effective management of the disease. Theranostics focuses on patient-centered care and thus provides a transition from conventional to personalized medicine for targeted, efficient and safe pharmacotherapy relevantly applicable in precision oncology [49,50].…”

Section: Signaling Pathway Deregulation and Targeted Drug Therapy Of ...mentioning

confidence: 99%

Precision Oncology, Signaling Pathways Reprogramming and Targeted Therapy: A Holistic Approach to Molecular Cancer Therapeutics

KUMAR

2024

Preprint

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In recent decades, there has been a deluge in the large-scale production of anticancer agents, primarily due to advances in genomic technologies enabling precise targeting of oncogenic pathways involved in disease progression. This initiated a paradigm shift in cancer research and therapeutics based on the ability to study molecular changes throughout the genome. It provided a unique opportunity in the field of translational cancer research and have led to the concept of precision medicine in cancer therapy, raising hopes of developing better diagnostic and therapeutic means for the management of cancer. The purpose of this article is to briefly review the tools and techniques involved in precision oncology research and their applications in the field of cancer treatment.

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Section: Signaling Pathway Deregulation and Targeted Drug Therapy Of ...mentioning

confidence: 99%

Precision Oncology, Signaling Pathways Reprogramming and Targeted Therapy: A Holistic Approach to Molecular Cancer Therapeutics

KUMAR

2024

Preprint

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Section: Precision Oncology and Targeted Drug Therapy Of Cancermentioning

confidence: 99%

Targeting Cancer Cell Signaling Using Precision Oncology Towards a Holistic Approach to Cancer Therapeutics

KUMAR

2024

Preprint

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Cancer is a complex and multifaceted disease having a number of composite problems to be considered including cancer immune evasion, therapy resistance, and recurrence for prevention and cure. Fundamentally it remains a genetic disease as diverse aspects of the complexity of tumor growth and cancer development relate to its genetic machinery and requires addressing the problems at the level of genome and epigenome. Presumably, the mutational changes occurring in the regulatory genes responsible for maintaining optimal cell growth, proliferation, and differentiation gradually lead to cancer progression and metastasis. Importantly, patients with the same cancer types respond differently to cancer therapies, indicating the need for a patient-specific treatment option for cancer cure. Precision oncology is a form of cancer therapy that focuses on the genetic profiling of individual tumors to identify molecular alterations involved in cancer development for custom-tailored personalized treatment of the disease. It is to rely upon the genomic study of cancer cells to get a clear picture of the prognosis and pathways involved in disease progression and to look for the means to selectively target them to ensure effective treatment of the deadly disease. Precision oncology now combines cancer diagnosis and prognosis followed by designing a treatment regimen for precise treatment of cancer at different stages and times. Recent advances in molecular technologies have indeed accelerated the implementation of precision oncology management, leading to improved clinical outcomes in selected cohorts of patients. This article aims to briefly explain the foundations and frontiers of precision oncology in the context of ongoing technological advances in this regard to assess its scope and importance in the realization of a proper cure for cancer.

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“…The core idea is to select the most suitable molecule (diagnostic and therapeutic) for the right patient, to improve treatment outcomes, and to minimize toxicity. Theranostics relies on whole-body molecular imaging to assess the expression and the accessibility of the target, followed by radioligand therapy, using the same molecule or a similar but differentially radiolabeled one to image and irradiate tumor cells, while sparing healthy surrounding tissue [17]. The potential of this approach has garnered positive evaluations in clinical practice in cases of prostate cancer (PC, 68 Ga-PSMA-11/ 177 Lu-PSMA-617) and neuroendocrine tumors (NET, 68 Ga-DOTA-TATE/ 177 Lu-DOTA-TATE), leading to FDA approval [18,19].…”

Section: Introductionmentioning

confidence: 99%

Recent Pre-Clinical Advancements in Nuclear Medicine: Pioneering the Path to a Limitless Future

Echavidre,

Fagret,

Faraggi

et al. 2023

Cancers

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The theranostic approach in oncology holds significant importance in personalized medicine and stands as an exciting field of molecular medicine. Significant achievements have been made in this field in recent decades, particularly in treating neuroendocrine tumors using 177-Lu-radiolabeled somatostatin analogs and, more recently, in addressing prostate cancer through prostate-specific-membrane-antigen targeted radionuclide therapy. The promising clinical results obtained in these indications paved the way for the further development of this approach. With the continuous discovery of new molecular players in tumorigenesis, the development of novel radiopharmaceuticals, and the potential combination of theranostics agents with immunotherapy, nuclear medicine is poised for significant advancements. The strategy of theranostics in oncology can be categorized into (1) repurposing nuclear medicine agents for other indications, (2) improving existing radiopharmaceuticals, and (3) developing new theranostics agents for tumor-specific antigens. In this review, we provide an overview of theranostic development and shed light on its potential integration into combined treatment strategies.

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Precision medicine and theranostics using radiopharmaceuticals in oncology

Abstract: The recent themed issue of the Journal on precision medicine-based drug treatment individualization in oncology (Volume 87, Issue 2) discusses a wide range of aspects of the precision medicine approach, including pharmacogenomics and therapeutic drug monitoring. To add

Cited by 11 publications

References 15 publications

Precision Oncology, Signaling Pathways Reprogramming and Targeted Therapy: A Holistic Approach to Molecular Cancer Therapeutics

Precision Oncology, Signaling Pathways Reprogramming and Targeted Therapy: A Holistic Approach to Molecular Cancer Therapeutics

Targeting Cancer Cell Signaling Using Precision Oncology Towards a Holistic Approach to Cancer Therapeutics

Recent Pre-Clinical Advancements in Nuclear Medicine: Pioneering the Path to a Limitless Future

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