Precision and Advanced Nano-Phytopharmaceuticals for Therapeutic Applications

Abstract

Phytopharmaceuticals have been widely used globally since ancient times and acknowledged by healthcare professionals and patients for their superior therapeutic value and fewer side-effects compared to modern medicines. However, phytopharmaceuticals need a scientific and methodical approach to deliver their components and thereby improve patient compliance and treatment adherence. Dose reduction, improved bioavailability, receptor selective binding, and targeted delivery of phytopharmaceuticals can be likely achieved by molding them into specific nano-formulations. In recent decades, nanotechnology-based phytopharmaceuticals have emerged as potential therapeutic candidates for the treatment of various communicable and non-communicable diseases. Nanotechnology combined with phytopharmaceuticals broadens the therapeutic perspective and overcomes problems associated with plant medicine. The current review highlights the therapeutic application of various nano-phytopharmaceuticals in neurological, cardiovascular, pulmonary, and gastro-intestinal disorders. We conclude that nano-phytopharmaceuticals emerge as promising therapeutics for many pathological conditions with good compliance and higher acceptance.

Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches

“…Since the phytopharmaceuticals used would not have site-specific targeting therefore the use of nanotechnology-based drug delivery systems is being learned about. This can address a number of safety issues including biocompatibility, potential toxicity (of unknown natural substances), and a dearth of clinical studies on medicinal plants and herbal remedies [357][358][359].…”

“…To ensure patient safety, a thorough study of the long-term effects of quantum dots on the skin and body is required. For the sake of reducing the possibility of hazardous or unfavorable reactions, the materials utilized to make quantum dots must be biocompatible [357].…”

The Role of Medicinal and Aromatic Plants against Obesity and Arthritis: A Review

“…Flavonoids are natural polyphenolic compounds with antioxidant, anti-inflammatory, and antiviral properties, as well as protective effects on the gastrointestinal tract [ 379 , 380 , 381 , 382 ]. Apigenin, cyanidin, (-)-epigallocatechin-3-O-gallate (EGCG), genistein, kaempferol, luteolin, puerarin, and quercetin are all antioxidants ( Table 6 ); therefore, these compounds demonstrate an inverse relationship between oxidative stress and arthritis, with or without obesity [ 383 , 384 , 385 , 386 , 387 ].…”

Stixis scandens leaf extract-loading ZnO nanoparticles for porcine epidemic diarrhea virus (PEDV) treatment

“…Developing nanoformulations of medicinal substances from plants is a potential trend in the treatment of many virus diseases. 17 There are various nanoformulations used as antiviral drug delivery vehicles such as lipid nanosystems, polymer nanosystems, lipid–polymer nanosystems, carbon nanocomposites, metal nano/inorganic metal oxides…, 18 among which nano ZnO nanoformulations show much potential.…”