Precise preparation of four-arm-poly(ethylene glycol)-block-poly(trimethylene carbonate) star block copolymers via activated monomer mechanism and examination of their solution properties

Cho, Jae Song; Kim, Byung Soo; Hyun, Hoon; Youn, Ju Yong; Kim, Moon Suk; Ko, Jae Hoon; Park, Young Hwan; Khang, Gilson; Lee, Hai Bang

doi:10.1016/j.polymer.2008.02.030

Cited by 29 publications

(22 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After mixing, the THF was removed by rotary evaporation at 40°C for 2 h. The final concentration of pyrene was 6.0 ! 10 -7 mol/L [12,13]. The copolymers were dissolved in the aqueous pyrene solution at various concentrations between 1.0 !…”

Section: Determination Of Critical Association Concentrationmentioning

confidence: 99%

Characterization of Temperature-Responsive Graft Copolymer with Polycarbonate Oligo Segment

Nitta

Kimoto

Watanabe

et al. 2015

Trans. Mat. Res. Soc. Japan

View full text Add to dashboard Cite

Graft copolymers with temperature-responsive units were designed and synthesized using a macromonomer method. A hydrophilic monomer was copolymerized with a macromonomer with a hydrophobic oligo segment. The copolymer spontaneously formed polymer colloids by intermolecular interactions in aqueous solutions. The copolymers were analyzed by UV-Vis spectroscopy, dynamic light scattering, and a fluorescence probe technique under different temperatures. The particle size of the copolymer colloids ranged from 20 to 60 nm at 25°C and larger aggregates were observed at higher temperatures. Increasing the hydrophilic N-hydroxyethyl acrylamide monomer units in the copolymer was induced by decreasing of lower critical solution temperature along with polymeric aggregation. The molecular incorporation of the copolymer was estimated using pyrene as a fluorescence probe, and the change in critical association concentration (CAC) was estimated. The CAC values for the copolymers with hydrophobic segments were estimated to be between 3.0 ! 10 -2 and 4.0 ! 10 -2 mg/mL. In addition, the copolymers formed stable colloids in aqueous media.

show abstract

Section: Determination Of Critical Association Concentrationmentioning

confidence: 99%

Characterization of Temperature-Responsive Graft Copolymer with Polycarbonate Oligo Segment

Nitta

Kimoto

Watanabe

et al. 2015

Trans. Mat. Res. Soc. Japan

View full text Add to dashboard Cite

show abstract

“…The degree of polymerization (DP) was calculated from the 1 H NMR spectrum. 1 H NMR (500 MHz, CDCl 3 ) δ: 2.1 (m, 2H,…”

Section: Synthesis Of Heaa-ptmc Macromonomermentioning

confidence: 99%

“…Amphiphilic copolymers are known to have their solubility, configuration, and aggregation size controlled by varying the hydrophobic-hydrophilic balance [1]. Moreover, their solubility properties and polymer structures can be modified for use in a variety of fields such as cosmetics, painting, print, medicine, and food additives.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, their solubility properties and polymer structures can be modified for use in a variety of fields such as cosmetics, painting, print, medicine, and food additives. Among them, amphiphilic copolymers, which possess both biodegradable and biocompatible properties have been widely investigated for applications such as to apply for drug carriers, etc [1][2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…However, ring-opening polymerization (ROP) of TMC is not known to proceed by the activation of the amide group in the presence of an organic catalyst [1][2][3][4][5][6][7][8]. In addition, PTMC oligomers have not been widely studied.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Synthesis of Functional Macromonomers with Oligo Segment of Polycarbonate for Biomaterials

Nitta

Miyake

Watanabe

et al. 2012

Trans. Mat. Res. Soc. Japan

View full text Add to dashboard Cite

New macromonomers based on poly(trimethylene carbonate) (PTMC) were designed and synthesized under precisely controlled conditions using conventional ring-opening polymerization (ROP) techniques. We found that PTMC was connected via the hydroxyl group of N-hydroxyethyl acrylamide (HEAA) or 2-hydroxyethyl acrylate (HEA). However, the preparation of the macromonomers was strongly affected by the concentration of the organic catalyst, inducing unfavorable side reactions. Optimized ROP could be performed by adjusting the concentration of the organic catalyst, 1,8-diazabicyclo[5.4.0]undec-7-ene. The polymerization degree of HEAA-PTMC and HEA-PTMC was maintained in the range of 10 to 50. The reaction was confirmed from the results of 1 H NMR. In this study, we focused on HEAA-PTMC macromonomers. We synthesized the amphiphilic graft copolymer using HEAA and optimal synthetic conditions were proposed.

show abstract

Molecular Technology for Degradable Synthetic Hydrogels for Biomaterials

Ajiro

Sakai

2019

Molecular Technology

View full text Add to dashboard Cite

Precise preparation of four-arm-poly(ethylene glycol)-block-poly(trimethylene carbonate) star block copolymers via activated monomer mechanism and examination of their solution properties

Cited by 29 publications

References 22 publications

Characterization of Temperature-Responsive Graft Copolymer with Polycarbonate Oligo Segment

Characterization of Temperature-Responsive Graft Copolymer with Polycarbonate Oligo Segment

Synthesis of Functional Macromonomers with Oligo Segment of Polycarbonate for Biomaterials

Molecular Technology for Degradable Synthetic Hydrogels for Biomaterials

Contact Info

Product

Resources

About