Precise pitch-scaling of carbon nanotube arrays within three-dimensional DNA nanotrenches

Sun, Wei; Shen, Jie; Zhao, Zhao; Arellano, Noel; Rettner, Charles; Tang, Jianshi; Cao, Tianyang; Zhou, Zhiyu; Ta, Toan; Streit, Jason K.; Fagan, Jeffrey; Schaus, Thomas E.; Zheng, Ming; Han, Shu‐Jen; Shih, William M.; Maune, Hareem; Yin, Peng

doi:10.1126/science.aaz7440

Cited by 108 publications

(121 citation statements)

References 35 publications

(30 reference statements)

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“…sufficient drain current for field-effect transistors 79,250 ). Therefore, a method is sought-after to produce networks of parallel aligned GNRs, as the resistance along the ribbon is up to three orders of magnitude lower than the resistance between ribbons 254 (the same principle also constitutes the main drive behind recent work to prepare aligned arrays of carbon nanotubes 255,256 ). The synthesis of an aligned network of GNRs was first achieved by Linden et al 77 by the use of a vicinal Au(788) surface.…”

Section: Aligned Networkmentioning

confidence: 99%

Atomically precise graphene nanoribbons: interplay of structural and electronic properties

2021

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Section: Aligned Networkmentioning

confidence: 99%

Atomically precise graphene nanoribbons: interplay of structural and electronic properties

2021

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“…In the early years, it was a major accomplishment to even design and construct simple wireframe structures from a small number of oligonucleotides [9,104]. Nowadays, large, often intricately complex, structures consisting of several hundred or more strands, which can template the positions of large collections of accessory molecules, are used for applications that range from synthetic vaccines [105] to the nanofabrication of inorganic materials and substrates [54,95,[106][107][108][109], or measurements of molecular forces that are exerted by single proteins [107].…”

Section: Discussionmentioning

confidence: 99%

“…These features make this method an attractive strategy for industrial nanofabrication, where nanoscale precision over distances approaching wafer sizes are invaluable. Indeed, one of the most promising studies based upon this technique demonstrates unprecedented long-range spatial control over the placement of carbon nanotubes, pointing towards a potential real-world future in nano-circuitry [54]. Nevertheless, the application of DNA bricks in research or practical applications has hardly moved the needle in comparison to DNA origami, and it largely remains a niche technique most frequently used to study addressable self-assembly [55][56][57][58][59][60][61][62][63][64][65].…”

Section: Dna Tiles and Dna Bricksmentioning

confidence: 99%

The Art of Designing DNA Nanostructures with CAD Software

et al. 2021

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Since the arrival of DNA nanotechnology nearly 40 years ago, the field has progressed from its beginnings of envisioning rather simple DNA structures having a branched, multi-strand architecture into creating beautifully complex structures comprising hundreds or even thousands of unique strands, with the possibility to exactly control the positions down to the molecular level. While the earliest construction methodologies, such as simple Holliday junctions or tiles, could reasonably be designed on pen and paper in a short amount of time, the advent of complex techniques, such as DNA origami or DNA bricks, require software to reduce the time required and propensity for human error within the design process. Where available, readily accessible design software catalyzes our ability to bring techniques to researchers in diverse fields and it has helped to speed the penetration of methods, such as DNA origami, into a wide range of applications from biomedicine to photonics. Here, we review the historical and current state of CAD software to enable a variety of methods that are fundamental to using structural DNA technology. Beginning with the first tools for predicting sequence-based secondary structure of nucleotides, we trace the development and significance of different software packages to the current state-of-the-art, with a particular focus on programs that are open source.

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“…Based on straightforward Watson-Crick base pairing, DNA nanotechnology offers exceptional control over the shape, size, geometry, and site-specific functionalization of DNA nanostructures [10][11][12][13][14][15] . DNA nanostructures can be further designed as dynamic molecular devices, also known as "DNA nanomachines" [16][17][18] .…”

Section: Mainmentioning

confidence: 99%

Genetically Encoding Ultra-Stable Virus-like Particles Encapsulating Functional DNA Nanostructures in Living Bacteria

Zilberzwige‐Tal

Alon

Gazit

et al. 2020

Preprint

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DNA nanotechnology is leading the field of in vitro molecular-scale device engineering, accumulating to a dazzling array of applications from zeolite-like catalysts to bio-imaging. However, while DNA nanostructures' function is robust under in vitro settings, their implementation in real-world conditions requires overcoming their rapid degradation and subsequent loss of function. Viruses are incredibly sophisticated supramolecular assemblies, able to protect their nucleic acid content in the relatively inhospitable biological environment. Inspired by this natural ability, we engineered both in vitro and in vivo technologies, enabling the encapsulation and protection of functional DNA nanostructures inside MS2 bacteriophage virus-like particles (VLPs). We demonstrate the ssDNA-VLPs nanocomposites (NCs) abilities to encapsulate single-stranded-DNA (ssDNA) of an unprecedented variety of sizes (200–1500 nucleotides (nt)), sequences, and structures while retaining their functionality. Moreover, by exposing these NCs to hostile biological conditions, such as human blood serum, we exhibit that the VLPs serves as an excellent protective shell. To the best of our knowledge, these engineered NCs pose key properties that are yet unattainable by current fabrication methods.

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Precise pitch-scaling of carbon nanotube arrays within three-dimensional DNA nanotrenches

Cited by 108 publications

References 35 publications

Atomically precise graphene nanoribbons: interplay of structural and electronic properties

Atomically precise graphene nanoribbons: interplay of structural and electronic properties

The Art of Designing DNA Nanostructures with CAD Software

Genetically Encoding Ultra-Stable Virus-like Particles Encapsulating Functional DNA Nanostructures in Living Bacteria

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