Precise optical dosimetry in low-level laser therapy of soft tissues in oral cavity

Stoykova, Elena; Sabotinov, O.

doi:10.1117/12.563280

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…As an approach to resolve these issues, laser penetration through tissues was studied numerically mostly using a single-layer model for the human skin. [12][13][14][15][16][17][18][19][20] For example, Roeva et al 18 investigated the laser penetration by applying LLLT on 142 patients and also evaluating light delivery within the tissue using the Monte Carlo method. They simulated human tissue as a single-layer medium with constant optical properties and showed the effect of absorption and scattering coefficients on laser penetration in the skin.…”

Section: Introductionmentioning

confidence: 99%

“…They simulated human tissue as a single-layer medium with constant optical properties and showed the effect of absorption and scattering coefficients on laser penetration in the skin. Moreover, Stoykova and Sabotinov 19 considered a single-layer model for periodontal tissue and investigated the influences of tissue optical properties (anisotropy factor, tissue refraction index, etc.) on energy deposition within the medium.…”

Section: Introductionmentioning

confidence: 99%

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Simulation of laser propagation through a three-layer human skin model in the spectral range from 1000 to 1900 nm

2014

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For understanding the mechanisms of low-level laser/light therapy (LLLT), accurate knowledge of light interaction with tissue is necessary. We present a three-dimensional, multilayer reduced-variance Monte Carlo simulation tool for studying light penetration and absorption in human skin. Local profiles of light penetration and volumetric absorption were calculated for uniform as well as Gaussian profile beams with different spreads over the spectral range from 1000 to 1900 nm. The results showed that lasers within this wavelength range could be used to effectively and safely deliver energy to specific skin layers as well as achieve large penetration depths for treating deep tissues, without causing skin damage. In addition, by changing the beam profile from uniform to Gaussian, the local volumetric dosage could increase as much as three times for otherwise similar lasers. We expect that this tool along with the results presented will aid researchers in selecting wavelength and laser power in LLLT.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Simulation of laser propagation through a three-layer human skin model in the spectral range from 1000 to 1900 nm

2014

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“…The probabilistic interpretation of the radiative transfer equation (RTE), which theoretically describes the photon movement in turbid media, leads to a statistical MC photon migration process 19,20 . In practice, MC-based photon migration simulation has been used in the research on in-vivo optical measurement and noninvasive biomedical diagnosis technology to investigate the distribution of illuminated photons in biological tissue 12,[21][22][23][24][25][26][27][28][29][30] . A lot of study on modeling sampling volume and spectra in relation to fiber-optics probes have been conducted [31][32][33] , voxelized MC 18 or GPU acceleration [34][35][36] www.nature.com/scientificreports/ learning combined MC methods were utilized to reduce time-consuming calculations [37][38][39][40][41] , yet sparse research has been performed in SWIR wavelength range.…”

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confidence: 99%

Performance estimation of optical skin probe in short wavelength infrared spectroscopy based on Monte-Carlo simulation

Lee

Ahn

Nam

2022

Sci Rep

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Optical throughput and optical path length are key parameters to obtain high signal to noise ratio and sensor sensitivity for the detection of skin tissue components based on short wavelength infrared (SWIR) spectroscopy. These parameters should be taken into account at the stage of optical system design. We aim to develop a method to estimate the optical efficiency and the effective water path length of a newly designed SWIR spectroscopy skin measurement system using Monte-Carlo photon migration simulation. To estimate the optical efficiency and the effective water path length, we investigated the characteristics of Monte-Carlo photon migration simulation utilizing one layered simple skin model. Simulation of photon transport in skin was conducted for transmission, transflection, and reflection optical configurations in both first overtone (1540 ~ 1820 nm) and combination (2040 ~ 2380 nm) wavelength ranges. Experimental measurement of skin spectrum was done using Fourier transform infrared spectroscopy based system to validate the estimation performance. Overall, the simulated results for optical efficiency and effective water path length are in good agreements with the experimental measurements, which shows the suggested method can be used as a means for the performance estimation and the design optimization of various in-vivo SWIR spectroscopic system.

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Performance estimation of optical skin probe in short wavelength infrared spectroscopy based on Monte-Carlo simulation

Lee

Ahn

Nam

2022

Preprint

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Optical throughput and optical path length are key parameters to obtain high signal to noise ratio and sensor sensitivity for the detection of skin tissue components based on short wavelength infrared (SWIR) spectroscopy. These parameters should be taken into account at the stage of optical system design. We aim to develop a method to estimate the optical efficiency and the effective water path length of a newly designed SWIR spectroscopy skin measurement system using Monte-Carlo photon migration simulation. To estimate the optical efficiency and the effective water path length, we investigated the characteristics of Monte-Carlo photon migration simulation utilizing one layered simple skin model. Simulation of photon transport in skin was conducted for transmission, transflection, and reflection optical configurations in both first overtone (1540 ~ 1820 nm) and combination (2040 ~ 2380 nm) wavelength ranges. Experimental measurement of skin spectrum was done using Fourier transform infrared spectroscopy based system to validate the estimation performance. The simulated results for optical efficiency are in good agreements with the experimental measurements, which shows the suggested method can be used as a means for the performance estimation and the design optimization of various in-vivo SWIR spectroscopic system.

show abstract

Precise optical dosimetry in low-level laser therapy of soft tissues in oral cavity

Cited by 4 publications

References 7 publications

Simulation of laser propagation through a three-layer human skin model in the spectral range from 1000 to 1900 nm

Simulation of laser propagation through a three-layer human skin model in the spectral range from 1000 to 1900 nm

Performance estimation of optical skin probe in short wavelength infrared spectroscopy based on Monte-Carlo simulation

Performance estimation of optical skin probe in short wavelength infrared spectroscopy based on Monte-Carlo simulation

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