Precise Manufacturing and Performance Validation of Paper-Based Passive Microfluidic Micromixers

Samae, Mahdee; Ritmetee, Pawarit; Chirasatitsin, Somyot; Kojić, Sanja; Kojić, Tijana; Jevremov, Jovana; Stojanović, Goran M.; Al‐Salami, Hani

doi:10.1007/s12541-019-00272-0

Cited by 12 publications

(4 citation statements)

References 35 publications

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“…This hydrophobicity leads to increased pressure and resistance of a liquid to flow through the microchannels. The most popularly used polymers in the fabrication of microfluidics include polymethyl methacrylate (Matellan & Armando, 2018 ; Kotz et al., 2020 ), polyvinyl chloride (Sitanurak et al., 2019 ; Samae et al., 2020 ), and polyethylene terephthalate (Cui et al., 2020 ; Kim et al., 2021 ), and polydimethylsiloxane (PDMS) (Hiltunen et al., 2018 ; Akther et al., 2020 ; Ferraz et al., 2020 ).…”

Section: Approaches For Efficient Microfluidicsmentioning

confidence: 99%

Merits and advances of microfluidics in the pharmaceutical field: design technologies and future prospects

et al. 2022

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Microfluidics is used to manipulate fluid flow in micro-channels to fabricate drug delivery vesicles in a uniform tunable size. Thanks to their designs, microfluidic technology provides an alternative and versatile platform over traditional formulation methods of nanoparticles. Understanding the factors that affect the formulation of nanoparticles can guide the proper selection of microfluidic design and the operating parameters aiming at producing nanoparticles with reproducible properties. This review introduces the microfluidic systems’ continuous flow (single-phase) and segmented flow (multiphase) and their different mixing parameters and mechanisms. Furthermore, microfluidic approaches for efficient production of nanoparticles as surface modification, anti-fouling, and post-microfluidic treatment are summarized. The review sheds light on the used microfluidic systems and operation parameters applied to prepare and fine-tune nanoparticles like lipid, poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles as well as cross-linked nanoparticles. The approaches for scale-up production using microfluidics for clinical or industrial use are also highlighted. Furthermore, the use of microfluidics in preparing novel micro/nanofluidic drug delivery systems is presented. In conclusion, the characteristic vital features of microfluidics offer the ability to develop precise and efficient drug delivery nanoparticles.

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Section: Approaches For Efficient Microfluidicsmentioning

confidence: 99%

Merits and advances of microfluidics in the pharmaceutical field: design technologies and future prospects

et al. 2022

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“…Mixing fluids is an important process in chemical engineering 1 , 2 , food engineering 3 , electronics, mining 4 , and others. Until now, lots of studies have been conducted to improve the efficiency of the mixing ratio with diverse mixer designs 3 , 4 .…”

Section: Introductionmentioning

confidence: 99%

“…Until now, lots of studies have been conducted to improve the efficiency of the mixing ratio with diverse mixer designs 3 , 4 . As the advancement of various industrial fields and environmental issues are raised, the mixing process of chemicals requires high performance as well as low pollution and safety 2 – 7 . For example, PPO (polyphenylene oxide), is one of the key materials for fifth-generation (5G) communication antennas with good electrical performance, low dielectric loss, and small change in dielectric performance with a wide range of frequencies.…”

Section: Introductionmentioning

confidence: 99%

Design and evaluation of additive manufactured highly efficient inclined-wing type continuous mixer

Baek

Yang

et al. 2022

Sci Rep

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We develop a novel milli-scale mixer (tilted-wings mixing unit, TWM unit) based on the design for additive manufacturing (DfAM). The proposed tilted-wings mixer has basically designed to have three separate wings that split and combine fluids in order to mix together effectively. Its structure is simple for easy fabrication: two major design parameters of angle among three wings and connecting angle between tilted-unit, which are optimized using the computational fluid dynamics (CFD) analysis. From the CFD analysis, we obtain the best-combined mixing module from analyses of various combinations of TWM units for a highly effective mixing ratio. The mixing ratio of three combined units reaches near 100%, which is validated by the experiment and analysis. We believe that the proposed milli-scale mixer can be utilized in diverse chemical continuous mixers and reactors for minimizing of use of chemicals that can pollute the environment.

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“…Moreover, the techniques for paper-based microfluidics [13,14], such as hydrophobic-ink printing and masking, have a low resolution of patterns, a requirement for specific equipment and reagents. On the other hand, the xurographic technique [15][16][17] using both polymer and paper involves the use of a cutting plotter to create microchannels with the desired patterns, enabling the fabrication of inexpensive devices and materials in a short amount of time (a few minutes) without the need for robust devices and specific substances. Therefore, xurography could be chosen for microfabrication for both polymer and paper.…”

Section: Introductionmentioning

confidence: 99%

Hemagglutination Detection with Paper–Plastic Hybrid Passive Microfluidic Chip

2021

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Hemagglutination is a critical reaction that occurs when antigens expressed on red blood cells (RBCs) react with the antibodies used for blood typing. Even though blood typing devices have been introduced to the market, they continue to face several limitations in terms of observation by the eye alone, blood manipulation difficulties, and the need for large-scale equipment, particularly process automated machines. Thus, this study aimed to design, fabricate, and test a novel hybrid passive microfluidic chip made of filter paper and polymer using a cost-effective xurography manufacturing technique. This chip is referred to as the microfluidic paper–plastic hybrid passive device (PPHD). A passive PPHD does not require external sources, such as a syringe pump. It is composed of a paper-based component that contains dried antibodies within its porous paper and a polymer component that serves as the detection zone. A single blood sample was injected into the chip’s inlet, and classification was determined using the mean intensity image. The results indicated that embedded antibodies were capable of causing RBC agglutination without a saline washing step and that the results could be classified as obviously agglutination or nonagglutination for blood typing using both the naked eye and a mean intensity image. As a proof-of-concept, this study demonstrated efficiency in quantitative hemagglutination measurement within a passive PPHD for blood typing, which could be used to simplify blood biomarker analysis.

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Precise Manufacturing and Performance Validation of Paper-Based Passive Microfluidic Micromixers

Cited by 12 publications

References 35 publications

Merits and advances of microfluidics in the pharmaceutical field: design technologies and future prospects

Merits and advances of microfluidics in the pharmaceutical field: design technologies and future prospects

Design and evaluation of additive manufactured highly efficient inclined-wing type continuous mixer

Hemagglutination Detection with Paper–Plastic Hybrid Passive Microfluidic Chip

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