Precise grafting of macrocyclics and dendrons to a linear polymer chain

Abstract

Sequential growth of multifunctional telechelic polymer chains allowing grafting of polymeric dendrons and cyclics equally spaced along the backbone.

50th Anniversary Perspective: Block Polymers—Pure Potential

“…The coalescence of such intricate sequence and architectural effects represents a relatively unexplored direction in the context of block polymers, although promising reports with architecturally elaborate homopolymers suggest further evolution should be forthcoming. 74,75 Advances in synthetic chemistry also translate into essentially unlimited opportunities to precisely ornament macromolecules with useful functionality. One example intimately coupled to macroscopic performance is the installation of special "triggers" that upon appropriate provocation instigate polymer degradation.…”

“…One could envision extrapolating these concepts to construct complex three-dimensional molecular structures by precisely tailoring local rigidity, packing, and composition using a design toolkit including backbone and side-chain lengths and stiffness, grafting density, branch connectivity and position, and block distribution. The coalescence of such intricate sequence and architectural effects represents a relatively unexplored direction in the context of block polymers, although promising reports with architecturally elaborate homopolymers suggest further evolution should be forthcoming. , …”

Densely Arrayed Cage-Shaped Polymer Topologies Synthesized via Cyclopolymerization of Star-Shaped Macromonomers

“…Approach (ii) may be applied to the construction of cage -GPs by grafting a separately prepared cage-shaped macromolecule onto a reactive polymer backbone. This is probably feasible because some researchers have reported the synthesis of GPs possessing monocyclic side chains ( c -GPs) by the grafting onto method. ,− However, the necessity of preparing cage-shaped macromolecules containing a reactive functional group is a major hurdle in the way of realizing this approach. Furthermore, this strategy inherently produces poorly defined cage -GPs because the quantitative grafting of bulky polymeric chains is challenging.…”

Polymer‐Brush‐Grafted Mesoporous Silica Nanoparticles for Triggered Drug Delivery

“…However, unlike linear polymers, the chemical composition and monomer ratios for the preparation of these polymers must be precisely optimized; hence, it is relatively difficult to control the synthesis process and the complex purification for each stage may result in a low yield ,. Additionally, linear polymers are much more flexible to integrate with other polymer chains to achieve multifunctional merits, allowing for more diverse biomedical applications . These stimuli‐responsive linear molecules (e. g., linear polyamine, saccharide derivative and peptide sequence) can be densely end‐grafted onto the surface of MSNs to form a polymer brush layer inside the pore and/or on the surface of the porous NPs to block the pore entrance, and the “close/open” mechanism can be divided into “across/parallel” or “shorten” of the liner molecules .…”

“…[4,15] Additionally, linear polymers are much more flexible to integrate with other polymer chains to achieve multifunctional merits, allowing for more diverse biomedical applications. [16] These stimuli-responsive linear molecules (e. g., linear polyamine, saccharide derivative and peptide sequence) can be densely end-grafted onto the surface of MSNs to form a polymer brush layer inside the pore and/or on the surface of the porous NPs to block the pore entrance, and the "close/open" mechanism can be divided into "across/ parallel" or "shorten" of the liner molecules. [12] In the presence of different triggers like pH, temperature variation and light or ultrasound irradiation, the polymer brushes will extend to open the pore entrance to release the encapsulated cargoes.…”