Precise genome editing underlines the distinct contributions of mutations in
ERG11
,
ERG3
,
MRR1
, and
TAC1
genes to antifungal resistance in
Candida parapsilosis
Sophie Hartuis,
Isabelle Ourliac-Garnier,
Estelle Robert
et al.
Abstract:Candida parapsilosis
has recently emerged as a major threat due to the worldwide emergence of fluconazole-resistant strains causing clonal outbreaks in hospitals and poses a therapeutic challenge due to the limited antifungal armamentarium. Here, we used precise genome editing using CRISPR-Cas9 to gain further insights into the contribution of mutations in
ERG11
,
ERG3
,
MRR1
, and
TAC1
… Show more
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