Precise excision of transposons and point mutations induced by chemicals

Rusina, O.Yu.; Mirskaya, Ekaterina; Андреева, И. В.; Skavronskaya, A.G.

doi:10.1016/0165-7992(92)90102-n

Cited by 7 publications

(1 citation statement)

References 19 publications

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“…Several studies have recently indicated that mutations would be possible in bacteria which are 'environmentally induced' [71][72][73][74][75][76], although the issue is subject to debate [77,78]. It will be very interesting to find more evidence of regulatory circuits in bacteria that, sensing changing environments [79] or the presence of toxic compounds [80,81], switch on mechanisms leading to favorable genetic alterations.…”

Section: Discussionmentioning

confidence: 99%

Genetic adaptation of bacteria to chlorinated aromatic compounds

Meer

1994

FEMS Microbiology Reviews

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Genetic mechanisms in bacteria provide a continuous source of alterations in DNA sequences that may lead to favourable adaptations. Bacteria that use chlorinated aromatics as sole carbon and energy sources show evidence of these different genetic alterations. The distinct effects of single base-pair mutations on adaptation of bacterial strains (e.g. by changing the substrate specificity of a key metabolic enzyme or regulator protein) have been demonstrated in various studies. In addition to these small sequence modifications, intermolecular or intercellular gene exchange mechanisms can result in new strains with altered metabolic capabilities. The details of these evolutionary processes with respect to the metabolism of chlorobenzenes and chlorocatechols are reviewed in this manuscript.

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Section: Discussionmentioning

confidence: 99%

Genetic adaptation of bacteria to chlorinated aromatic compounds

Meer

1994

FEMS Microbiology Reviews

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α-Naphthylamine

1998

Toxological Evaluations

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Transposable elements and adaptation of host bacteria

Blot

1994

Genetica

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A transposable element (TE) is a mobile sequence present in the genome of an organism. TEs can cause lethal mutations by inserting into essential genes, promoting deletions or leaving short sequences upon excision. They therefore may be gradually eliminated from mixed populations of haploid micro-organisms such as Escherichia coli if they cannot balance this mutation load. Horizontal transmission between cells is known to occur and promote the transfer of TEs, but at rates often too low to compensate for the burden to their hosts. Therefore, alternative mechanisms should be found by these elements to earn their keep in the cells. Several theories have been suggested to explain their long-term maintenance in prokaryotic genomes, but little molecular evidence has been experimentally obtained. In this paper, the permanence of transposable elements in bacterial populations is discussed in terms of costs or benefits for the element and for the host. It is observed that, in all studies yet reported, the elements do not behave in their host as selfish DNA but as a co-operative component for the evolution of the couple.

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Precise excision of transposons and point mutations induced by chemicals

Cited by 7 publications

References 19 publications

Genetic adaptation of bacteria to chlorinated aromatic compounds

Genetic adaptation of bacteria to chlorinated aromatic compounds

α-Naphthylamine

Transposable elements and adaptation of host bacteria

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