Precise Examination of Peripheral Vascular Disease for Diabetics with a Novel Multiplexed NIR-II Fluorescence Imaging Technology

Huang, Haoying; Sun, Zhuqing; Yang, Hongchao; Yang, Xiaohu; Wu, Feng; Sun, Yao; Li, Chunyan; Tian, Mei; Zhang, Hong; Wang, Qiangbin

doi:10.1016/j.nantod.2022.101378

Cited by 34 publications

(24 citation statements)

References 29 publications

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“…An optimized combinational administration was programmed to achieve the enhanced therapeutical effects. In another work, Wang et al [ 87 ] synthesized the SY1100@Au:Ag 2 Te fluorescent probe (SY1100, λ Em = 1025 nm, Au: Ag 2 Te QDs, λ Em = 1600 nm), which not only helped realize NIR‐II two‐color imaging but also enabled precise quantitative grading of ischemia/reperfusion injury. Because SY1100 exhibits responsive quenching after encountering the target, this dual‐color probe can be quantitatively analyzed by ratio correction.…”

Section: Opportunitiesmentioning

confidence: 99%

Fluorescence Imaging in Second Near‐infrared Window: Developments, Challenges, and Opportunities

Liang

2022

Advanced NanoBiomed Research

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Fluorescence imaging is a noninvasive technique that affords real‐time fast feedback, high sensitivity, and harmless radiation and is thus effective in visualizing the anatomy and function of organs. Recently, second near‐infrared (NIR‐II, 1000–1700 nm) fluorescence imaging emerged as a popular imaging technique for both fundamental research and clinical practice, with strong potential for applications in the field of biomedicine. It affords a high signal‐to‐noise ratio and high spatial and temporal resolutions for the imaging of deep tissue owing to reduced scattering, minimal absorption, and negligible autofluorescence. Herein, the performance and advancement of fluorophores for NIR‐II fluorescence imaging are summarized. Further, the challenges to the NIR‐II fluorophores in terms of emission wavelengths, quantum yields, stability, targeting, and biocompatibility are discussed. Finally, perspective on the current development and the orientation for future studies on NIR‐II imaging, such as dual‐mode imaging, multiplexed imaging, surgical navigation, integrated diagnosis and treatment, and biosensing are discussed.

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Section: Opportunitiesmentioning

confidence: 99%

Fluorescence Imaging in Second Near‐infrared Window: Developments, Challenges, and Opportunities

Liang

2022

Advanced NanoBiomed Research

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“…Fluorescence imaging in the second near-infrared window (NIR-II, 1000-1700 nm) is developed rapidly for noninvasive deep tissue investigation with high spatio-temporal resolution due to diminished autofluorescence light attenuation 1 - 8 . For optical in vivo bioimaging, the penetration depth of photons is mainly influenced by the absorption and scattering of tissue components.…”

Section: Introductionmentioning

confidence: 99%

“…NIR-II fluorescence probes show potential in cancer imaging and diagnosis 40 , medical detection 8 , and vascular bioimaging 41 . It is worth noting that, repurposing NIR-I probes with emission in the NIR-II window, especially the ones approved clinically, provides an important development strategy for NIR-II fluorescence proves to accelerate the clinical translation 42 .…”

Section: Introductionmentioning

confidence: 99%

Activatable NIR-II organic fluorescent probes for bioimaging

Zhang¹,

Li²,

Ma³

et al. 2022

Theranostics

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NIR-II imaging is developed rapidly for noninvasive deep tissue inspection with high spatio-temporal resolution, taking advantage of diminished autofluorescence and light attenuation. Activatable NIR‐II fluorescence probes are widely developed to report pathological changes with accurate targeting, among which organic fluorescent probes achieve significant progress. Furthermore, the activatable NIR‐II fluorescent probes exhibited appealing characteristics like tunable physicochemical and optical properties, easy processability, and excellent biocompatibility. In the present review, we highlight the advances of activatable NIR-II fluorescence probes in design, synthesis and applications for imaging pathological changes like reactive oxygen species (ROS), reactive nitrogen species (RNS), reactive sulfur species (RSS), pH, hypoxia, viscosity as well as abnormally expressed enzymes. This non-invasive optical imaging modality shows a promising prospect in targeting the pathological site and is envisioned for potential clinical translation.

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“…[6][7][8][9] As the kernel of phototheranostic systems, the exploitation of phototheranostic agents (PTAs) with high performance is crucial to the development of phototheranostic research. [10][11][12][13][14][15] Especially, PTAs with second near-infrared (NIR-II, 1000-1700 nm) emission [16][17][18][19] are attracting extensive interest in the last few years for higher signal-to-noise ratio, deeper penetration depth, and lower light absorption, scattering, and autofluorescence interference from biological tissues. [20][21][22][23] In order to attain highly efficient NIR-II PTAs, four strategies are commonly used to red-shift absorption and emission wavelengths of fluorophores: [24][25][26][27][28][29][30][31] 1) lengthening the conjugated chain of fluorophores; 2) enhancing intramolecular donor-acceptor (D-A) interactions; 3) tuning the strength and number of donor/acceptor in the fluorophores; 4) fabricating J-aggregates.…”

mentioning

confidence: 99%

Fluorination Enhances NIR‐II Emission and Photothermal Conversion Efficiency of Phototheranostic Agents for Imaging‐Guided Cancer Therapy

Jiang

Jia

et al. 2022

Advanced Materials

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biotechnology. They play conspicuously and increasingly important roles in precise tumor treatment due to their minimal invasiveness, high temporal-spatial resolution, high biosafety, and highly efficient antitumor ability. [6][7][8][9] As the kernel of phototheranostic systems, the exploitation of phototheranostic agents (PTAs) with high performance is crucial to the development of phototheranostic research. [10][11][12][13][14][15] Especially, PTAs with second near-infrared (NIR-II, 1000-1700 nm) emission [16][17][18][19] are attracting extensive interest in the last few years for higher signal-to-noise ratio, deeper penetration depth, and lower light absorption, scattering, and autofluorescence interference from biological tissues. [20][21][22][23] In order to attain highly efficient NIR-II PTAs, four strategies are commonly used to red-shift absorption and emission wavelengths of fluorophores: [24][25][26][27][28][29][30][31] 1) lengthening the conjugated chain of fluorophores; 2) enhancing intramolecular donor-acceptor (D-A) interactions; 3) tuning the strength and number of donor/acceptor in the fluorophores; 4) fabricating J-aggregates. Although many efforts have been made, most reported NIR-II PTAs so far are mainly D-A-D and D-π-A type fluorophores. [32][33][34] While A-D-A type PTAs are rarely studied [35][36][37][38] Phototheranostics with second near-infrared (NIR-II) imaging and photothermal effect have become a burgeoning biotechnology for tumor diagnosis and precise treatment. As important parameters of phototheranostic agents (PTAs), fluorescence quantum yield (QY) and photothermal conversion efficiency (PCE) are usually considered as a pair of contradictions that is difficult to be simultaneously enhanced. Herein, a fluorination strategy for designing A-D-A type PTAs with synchronously improved QY and PCE is proposed. Experimental results show that the molar extinction coefficient (ε), NIR-II QY, and PCE of all fluorinated PTAs nanoparticles (NPs) are definitely improved compared with the chlorinated counterparts. Theoretical calculation results demonstrate that fluorination can maximize the electrostatic potential difference by virtue of the high electronegativity of fluorine, which may increase intra/intermolecular D-A interactions, tighten molecule packing, and further promote the increase of ε, ultimately leading to simultaneously enhanced QY and PCE. In these PTA NPs, FY6-NPs display NIR-II emission extended to 1400 nm with the highest NIR-II QY (4.2%) and PCE (80%). These features make FY6-NPs perform well in high-resolution imaging of vasculature and NIR-II imaging-guided photothermal therapy (PTT) of tumors. This study develops a valuable guideline for constructing NIR-II organic PTAs with high performance.

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Precise Examination of Peripheral Vascular Disease for Diabetics with a Novel Multiplexed NIR-II Fluorescence Imaging Technology

Cited by 34 publications

References 29 publications

Fluorescence Imaging in Second Near‐infrared Window: Developments, Challenges, and Opportunities

Fluorescence Imaging in Second Near‐infrared Window: Developments, Challenges, and Opportunities

Activatable NIR-II organic fluorescent probes for bioimaging

Fluorination Enhances NIR‐II Emission and Photothermal Conversion Efficiency of Phototheranostic Agents for Imaging‐Guided Cancer Therapy

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