Precise Design Strategies of Nanotechnologies for Controlled Drug Delivery

Huang, Shiyi; Li, Yiyang

doi:10.3390/jfb13040188

Cited by 3 publications

(3 citation statements)

References 148 publications

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“…The efficiency of cellular absorption is essential for the effectiveness of nanotherapy [ 122 , 123 ]. The cellular absorption of NPs is determined by some variables, including particle size, charge, hydrophilicity, and the presence of ligands.…”

Section: Csnps and Mechanism Anticancer Actionmentioning

confidence: 99%

Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy

et al. 2023

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Despite recent advances, cancer remains the primary killer on a global scale. Numerous forms of research have been conducted to discover novel and efficient anticancer medications. The complexity of breast cancer is a major challenge which is coupled with patient-to-patient variations and heterogeneity between cells within the tumor. Revolutionary drug delivery is expected to provide a solution to that challenge. Chitosan nanoparticles (CSNPs) have prospects as a revolutionary delivery system capable of enhancing anticancer drug activity and reducing negative impacts on normal cells. The use of smart drug delivery systems (SDDs) as delivering materials to improve the bioactivity of NPs and to understand the intricacies of breast cancer has garnered significant interest. There are many reviews about CSNPs that present various points of view, but they have not yet described a series in cancer therapy from cell uptake to cell death. With this description, we will provide a more complete picture for designing preparations for SDDs. This review describes CSNPs as SDDSs, enhancing cancer therapy targeting and stimulus response using their anticancer mechanism. Multimodal chitosan SDDs as targeting and stimulus response medication delivery will improve therapeutic results.

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Section: Csnps and Mechanism Anticancer Actionmentioning

confidence: 99%

Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy

et al. 2023

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“…In particular, nano-sized drug delivery systems have been extensively investigated because of their outstanding properties such as good stability and high drug load and their feasibility of incorporating both hydrophobic and hydrophilic molecules, as well as various drug administration routes (inhalation, oral, topical, and parenteral injection) [ 1 , 2 , 3 , 4 , 5 , 6 ]. Moreover, nanocarriers enable to improve the drug bioavailability, to diminish the dosing frequency, to reduce the side effects, and to achieve targeted drug delivery [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Polysaccharides as a Hydrophilic Building Block of Amphiphilic Block Copolymers for the Conception of Nanocarriers

Lu,

2024

Pharmaceutics

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Polysaccharides are gaining increasing attention for their relevance in the production of sustainable materials. In the domain of biomaterials, polysaccharides play an important role as hydrophilic components in the design of amphiphilic block copolymers for the development of drug delivery systems, in particular nanocarriers due to their outstanding biocompatibility, biodegradability, and structural versatility. The presence of a reducing end in polysaccharide chains allows for the synthesis of polysaccharide-based block copolymers. Compared with polysaccharide-based graft copolymers, the structure of block copolymers can be more precisely controlled. In this review, the synthesis methods of polysaccharide-based amphiphilic block copolymers are discussed in detail, taking into consideration the structural characteristics of polysaccharides. Various synthetic approaches, including reductive amination, oxime ligation, and other chain-end modification reactions, are explored. This review also focuses on the advantages of polysaccharides as hydrophilic blocks in polymeric nanocarriers. The structure and unique properties of different polysaccharides such as cellulose, hyaluronic acid, chitosan, alginate, and dextran are described along with examples of their applications as hydrophilic segments in the synthesis of amphiphilic copolymers to construct nanocarriers for sustained drug delivery.

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“…Leveraging the rapid advancements and diverse benefits of nanomedicine, which integrates nanotechnology with biomedicine, controlled-release nanomaterials have been developed for various therapeutic applications to address the limitations associated with CORMs. CO-releasing nanomaterials (CORNMs) possess several advantages, including: (1) their nanoscale dimensions enable high loading capacity, escape from biological barriers, and passive targeted enrichment [ [35] , [36] , [37] , [38] ], (2) their diverse compositions promote stability, responsiveness, biocompatibility, and degradability [ [39] , [40] , [41] ], and (3) their modified surfaces facilitate dispersibility, targetability and multifunctionality (combined therapy and theranostics) [ [41] , [42] , [43] ]. Additionally, the cytotoxicity can be reduced by removing any remaining metal residues or fragments together with the CORNMs following CO release [ 44 ].…”

Section: Introductionmentioning

confidence: 99%

Recent advances in carbon monoxide-releasing nanomaterials

Ning,

Zhu,

Wang

et al. 2024

Bioactive Materials

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Precise Design Strategies of Nanotechnologies for Controlled Drug Delivery

Cited by 3 publications

References 148 publications

Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy

Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy

Polysaccharides as a Hydrophilic Building Block of Amphiphilic Block Copolymers for the Conception of Nanocarriers

Recent advances in carbon monoxide-releasing nanomaterials

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