Precise control over supramolecular nanostructuresviamanipulation of H-bonding in π-amphiphiles

Abstract

Supramolecular polymers of programmable nanostructures have been achieved by introducing single/multiple H-bonding units in π-amphiphiles.

Elucidating the role of multivalency, shape, size and functional group density on antibacterial activity of diversified supramolecular nanostructures enabled by templated assembly

“…Neutral amphiphiles M1 and M2 were synthesised according to a previously reported procedure. 33 Cationic amphiphile PY was synthesised following the synthetic scheme described in the ESI (Scheme S1) and characterised by 1 H-NMR (Fig S1 ), 13 C-NMR (Fig S2 ) and ESI-MS spectroscopy. The co-assembly was investigated in aqueous medium unless otherwise specified.…”

“…On the other hand, amphiphile M1 is known to form micrometre long cylindrical micelles via π-π stacking and hydrophobic interactions. 33 When M1 and PY were co-assembled (detail sample preparation has been described in SI) in 1:1 ratio (calculated in mole %), UV-Vis of the aqueous solution…”

“…On the other hand, amphiphile M1 is known to form micrometre long cylindrical micelles via p-p stacking and hydrophobic interactions. 33 When M1 and PY were co-assembled (detailed sample preparation has been described in ESI †) in 1 : 1 ratio (calculated in mole %), UV-vis of the aqueous solution showed the emergence of a new peak at 550 nm (Fig. 1a) indicating the formation of the CT-complex by alternate stacking of the M1 and PY chromophores.…”

“…Considering the structural diversity along with conformational and functional integrity, supramolecular polymers are an ideal candidate to form different nanostructures with high structural precision to screen for antibacterial activity. In this context, we have recently reported 33 the formation of different shaped nanoparticles (spherical micelles, cylindrical micelles and 2D-nanoribbons) by interplaying the H-bonding, hydrophobic and π-π interactions using structurally near-identical πamphiphiles (M1 and M2 in Scheme 1) having the same hydrophilichydrophobic balance. Further to this, it is well established that charge-transfer (CT) interactions 34,35 between electron deficient and electron rich chromophores can be utilised for the construction of supramolecular nanomaterials (Scheme 1b).…”

Noncovalent Postmodification Guided Reversible Compartmentalization of Polymeric Micelles

“…Noncovalent interactions (including electrostatic interaction , or directed π–π interaction − ) are dynamically reversible under external stimulus. Externally regulating the assembly structure by noncovalent interaction would avoid some laborious synthetic efforts and make reversible regulation of assembly structures possible.…”