Precipitation parameters and the cytotoxicity of chitosan hydrochloride microparticles production by supercritical assisted atomization

Wu, Hsien-Tsung; Huang, Shih-Chang; Yang, Ching‐Chieh; Chien, Liang-Jung

doi:10.1016/j.supflu.2015.04.013

Cited by 17 publications

(11 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The PSD (Figure 5a) and mean size of the PEG particles (Figure 5b) increased with the concentration of the PEG solution, thus indicating that the high viscosity of the high concentration PEG solution resulted in larger liquid droplets and increased PEG particle sizes. Similar results have been reported, mostly for relevant SAA processes [13,14,15,16,17,18,25,26,27,28,29,30,31,32].…”

Section: Resultssupporting

confidence: 89%

Formation of Polyethylene Glycol Particles Using a Low-Temperature Supercritical Assisted Atomization Process

Tsai

2019

Molecules

Self Cite

View full text Add to dashboard Cite

Polyethylene glycol (PEG) particles were prepared using low-temperature supercritical assisted atomization (LTSAA) with carbon dioxide as the spraying medium or the co-solute and acetone as the solvent. The effects of several key factors on the particle size were investigated. These factors included the concentration of the PEG solution, precipitator temperature, saturator temperature, ratio of the volumetric flow rate of carbon dioxide to the PEG solution, and the molecular weight of PEG. Spherical and non-aggregated PEG particles, with a mean size of 1.7–3.2 µm, were obtained in this study. The optimal conditions to produce fine particles were found to be a low concentration of the PEG solution, a low precipitator temperature, and low molecular weight of the PEG. The phase behavior of the solution mixture in the saturator presented a qualitative relationship. At the optimized volumetric flow rate ratios, the composition of CO2 in the feed streams was near the bubble points of the saturator temperatures. X-ray and differential scanning calorimetry analyses indicated that LTSAA-treated PEG had a reduced degree of crystallinity, which could be modulated via the precipitator temperature. PEG microparticles prepared by a LTSAA process would be promising carriers for drug-controlled formulations of PEG-drug composite particles.

show abstract

Section: Resultssupporting

confidence: 89%

Formation of Polyethylene Glycol Particles Using a Low-Temperature Supercritical Assisted Atomization Process

Tsai

2019

Molecules

Self Cite

View full text Add to dashboard Cite

show abstract

“…Figure 4a indicates that the mean sizes of the HP-β-CD particles increased with the concentration of the HP-β-CD solution, which illustrates that the high viscosity of the HP-β-CD solution at high concentrations may result in large liquid droplets and increase the mean HP-β-CD particle size (d 4,3 ) in SAA. Similar results have been reported, mostly for relevant SAA processes [14,15,20,24,25,[27][28][29][30][31][32][33]. The mean particle size (d4,3) of the micronized HP-β-CD particles produced at different flow ratios (R) in the range of 1.4−2.8 (runs #2, and #16−18 in Table 1) are shown in Figure 4b.…”

Section: Effects Of the Precipitation Parameters On Hp-β-cd Particle Sizesupporting

confidence: 85%

“…RESS and SAS were not adopted in this study because of the solubility limitation of the applied solute in scCO 2 and the aqueous solvent in antisolvent of scCO 2 , respectively. SAA has been applied to aqueous and organic solvent systems to achieve a stable, high-yielding, and easily scalable process [ 13 , 14 , 15 ]. Reverchon and Antonacci [ 16 ] first reported α-CD and HP-β-CD micronization by SAA using water as the solvent.…”

Section: Introductionmentioning

confidence: 99%

Characterization and Aerosolization Performance of HydroxyPropyl-Beta-Cyclodextrin Particles Produced Using Supercritical Assisted Atomization

Chuang

Lin

et al. 2021

Polymers

Self Cite

View full text Add to dashboard Cite

In this study, hydroxypropyl-beta-cyclodextrin (HP-β-CD) particles were produced using supercritical assisted atomization (SAA) with carbon dioxide as the spraying medium or co-solute and aqueous ethanol solution as the solvent. The effects of several key factors on the morphology and size of the HP-β-CD particles were investigated. These factors included the solvent effect, temperatures of the precipitator and saturator, concentration of the HP-β-CD solution, and flow rate ratio of carbon dioxide to the HP-β-CD solution. The conducive conditions for producing fine spherical particles were 54.2% (w/w) aqueous ethanol as the solvent; precipitator and saturator temperatures of 373.2 K and 353.2 K, respectively; a flow rate ratio of carbon dioxide to HP-β-CD solution of 1.8; and low concentrations of HP-β-CD solution. The addition of leucine (LEU) enhanced the aerosol performance of the HP-β-CD particles, and the fine particle fraction (FPF) of the HP-β-CD particles with the addition of 13.0 mass% LEU was 1.8 times higher than that of the HP-β-CD particles without LEU. This study shows that LEU can act as a dispersion enhancer and that HP-β-CD particles produced using SAA can be used as pulmonary drug carriers.

show abstract

“…It is interesting to note, that scCO 2 methods produce a zero-net change in atmosphere amounts of CO 2 , as the CO 2 used in processing is gathered from industrial sites. In addition, SCF technologies can be scaled up, so simpler lab-bench equipment is sufficient for optimising methods that can be extrapolated to much larger sized equipment (Cansell et al, 2003;Cardea et al, 2010;Hakuta et al, 2003;Huang et al, 2005;Kim et al, 2007;Shariati and Peters, 2003;Wu et al, 2015). These desirable attributes create a need to explore new methodologies using scCO 2 in the field of liposomal drug delivery and nanotechnology.…”

Section: Introductionmentioning

confidence: 99%

Dispersibility of phospholipids and their optimization for the efficient production of liposomes using supercritical fluid technology

Maqbool

Moyle

Thurecht

et al. 2019

International Journal of Pharmaceutics

View full text Add to dashboard Cite

Liposomes are promising delivery vehicles and offer the added drawcard of being able to be made functional to target tissues such as cardiac muscle and cancerous cells. Current methods to manufacture liposomes need to be improved and supercritical fluid (SCF) technologies may offer a solution. Herein, the dispersibility of six different phospholipids (PLs): determined using supercritical carbon dioxide (scCO 2), and 1,2-distearoyl-sn-glycero-3phosphocholine (DSPC) showed highest post-processing dispersibility, while 1,2-dioleoyl-snglycero-3-phosphocholine (DOPC), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, (DOPE) and 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) showed no dispersibility at all in scCO 2 at the assessed experimental conditions. The zetasizer results showed that the SCF conditions at 37 °C, 250 bar and 200 RPM for 60 min provided nanoparticles with narrowest polydispersity index (PDI) and spherical shaped as shown by cryo-transmission electron microscopy (Cryo-TEM) supported these results. The mean diameter of liposomes using the SCF method for DSPC-PEGylated and DOPC-PEGylated liposomes was 98.3±3.3 nm and 124.5±4.1 nm, while using thin film method it was 153.6 ± 4.5 nm and 131.3±3.4 nm, respectively. The stability of liposomes stored at different temperatures (25 °C, 4 °C and-20 °C) using SCF technology was better over a period of 3 months. The current study would provide green alternative method, less laborious, save time and energy.

show abstract

Precipitation parameters and the cytotoxicity of chitosan hydrochloride microparticles production by supercritical assisted atomization

Cited by 17 publications

References 37 publications

Formation of Polyethylene Glycol Particles Using a Low-Temperature Supercritical Assisted Atomization Process

Formation of Polyethylene Glycol Particles Using a Low-Temperature Supercritical Assisted Atomization Process

Characterization and Aerosolization Performance of HydroxyPropyl-Beta-Cyclodextrin Particles Produced Using Supercritical Assisted Atomization

Dispersibility of phospholipids and their optimization for the efficient production of liposomes using supercritical fluid technology

Contact Info

Product

Resources

About