Precipitation and Agglutination

Cj, Van Oss

doi:10.1080/01971520009349532

Cited by 9 publications

(9 citation statements)

References 46 publications

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“…An obvious strategy was to employ the equivalence principle of antibody-antigen reactions involved in precipitin formation, [11][12][13] by reducing the concentration of Tag peptidemagnetic particles (a synthetic multivalent antigen) so that lower concentrations of anti-Tag antibodies might achieve aggregation. The Tag peptide from the influenza hemagglutinin was therefore conjugated to nanoparticles (NPs) and to far larger micrometer-sized magnetic particles (MPs) to yield Tag-NPs and Tag-MPs.…”

mentioning

confidence: 99%

Sensitive NMR Sensors Detect Antibodies to Influenza

et al. 2008

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mentioning

confidence: 99%

Sensitive NMR Sensors Detect Antibodies to Influenza

et al. 2008

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“…An obvious strategy was to employ the equivalence principle of antibody–antigen reactions involved in precipitin formation,11–13 by reducing the concentration of Tag peptide–magnetic particles (a synthetic multivalent antigen) so that lower concentrations of anti‐Tag antibodies might achieve aggregation. The Tag peptide from the influenza hemagglutinin was therefore conjugated to nanoparticles (NPs) and to far larger micrometer‐sized magnetic particles (MPs) to yield Tag–NPs and Tag–MPs.…”

Section: Properties Of Magnetic Particles (Mps) and Nanoparticles (Nps)mentioning

confidence: 99%

Sensitive NMR Sensors Detect Antibodies to Influenza

et al. 2008

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“…Biologic macromolecules are capable of sterically specific (chemically anisotropic) binding with particular ligands. 9 The reactants can bind to each other only at certain discrete reactive spots (active sites), which are relatively small comparing to the size of reactants. Therefore, one can expect significant steric factor for aggregation kinetics, since specific binding sites occupy a rather small surface fraction of a particle.…”

Section: Introductionmentioning

confidence: 99%

Brownian aggregation rate of colloid particles with several active sites

Nekrasov

Polshchitsin

Yurkin

et al. 2014

The Journal of Chemical Physics

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We theoretically analyze the aggregation kinetics of colloid particles with several active sites. Such particles (so-called "patchy particles") are well known as chemically anisotropic reactants, but the corresponding rate constant of their aggregation has not yet been established in a convenient analytical form. Using kinematic approximation for the diffusion problem, we derived an analytical formula for the diffusion-controlled reaction rate constant between two colloid particles (or clusters) with several small active sites under the following assumptions: the relative translational motion is Brownian diffusion, and the isotropic stochastic reorientation of each particle is Markovian and arbitrarily correlated. This formula was shown to produce accurate results in comparison with more sophisticated approaches. Also, to account for the case of a low number of active sites per particle we used Monte Carlo stochastic algorithm based on Gillespie method. Simulations showed that such discrete model is required when this number is less than 10. Finally, we applied the developed approach to the simulation of immunoagglutination, assuming that the formed clusters have fractal structure.

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Precipitation and Agglutination

Cited by 9 publications

References 46 publications

Sensitive NMR Sensors Detect Antibodies to Influenza

Sensitive NMR Sensors Detect Antibodies to Influenza

Sensitive NMR Sensors Detect Antibodies to Influenza

Brownian aggregation rate of colloid particles with several active sites

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