Precipitating Auto-Antibodies in the Connective Tissue Diseases

Anderson, John R.; Gray, Kathleen; Beck, J. Swanson; Buchanan, W. Watson; McElhinney, A. James

doi:10.1136/ard.21.4.360

Cited by 89 publications

(22 citation statements)

References 27 publications

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“…IgG antinuclear antibodies have been found in 96%, IgM in 81%o, and IgA in 51%o of SLE sera (7). The nuclear antigens to which these antibodies are directed have been studied by a variety of techniques including complement fixation (8)(9)(10), passive hemagglutination (2), precipitation (11)(12)(13), and agglutination of bentonite particles (14,15). These studies have all shown that a variety of nuclear antigens react with various SLE sera.…”

Section: Introductionmentioning

confidence: 99%

The Relation of Immunoglobulin Class, Pattern of Antinuclear Antibody, and Complement-Fixing Antibodies to DNA in Sera from Patients with Systemic Lupus Erythematosus*

Rothfield¹,

Stollar²

1967

J. Clin. Invest.

166

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Abstract. Sera from 55 patients with systemic lupus erythematosus were studied to clarify the significance of the patterns of nuclear fluorescence observed. The sera in which the IgG fraction produced a peripheral pattern of nuclear fluorescence were found to contain complement-fixing antibodies to native DNA and to DNA-histone complexes. This correlation did not exist when complement-fixing activity was compared to the IgM nuclear patterns. Sera which contained only complement-fixing antibodies to denatured DNA and which did not react with native DNA or nucleoprotein did not produce the peripheral pattern of nuclear fluorescence. The data suggest that single strands of DNA were not the reactive groups in the nucleus responsible for the peripheral pattern. The results support the conclusion that DNA within a DNA-protein complex may be the nuclear antigen responsible for the peripheral pattern of nuclear fluorescence.Analysis of the clinical data revealed that a close correlation existed between the presence of IgG peripheral pattern, complement-fixing antibodies to DNA and histone-DNA complexes, and clinical manifestation of active disease. IntroductionThe presence of antinuclear antibodies in sera from patients with systemic lupus erythematosus (SLE) has been described by many investigators (1-4). These antibodies have been shown to be-

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Section: Introductionmentioning

confidence: 99%

The Relation of Immunoglobulin Class, Pattern of Antinuclear Antibody, and Complement-Fixing Antibodies to DNA in Sera from Patients with Systemic Lupus Erythematosus*

Rothfield¹,

Stollar²

1967

J. Clin. Invest.

166

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“…Immunodiffusion in gel has been used to detect serum precipitating antibodies to tissue antigens (8)(9)(10)(11)(12). In these studies, extracts of human thyroid, spleen, and calf thymus nuclei have been used.…”

Section: Introductionmentioning

confidence: 99%

Antibodies to cellular antigens in Sjögren's syndrome.

Alspaugh¹,

Tan²

1975

J. Clin. Invest.

396

141

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“…46 In myasthenia gravis, an inverse correlation has been observed between levels of total hemolytic complement and exacerbations of disease activity.47 This has subsequently been shown to be due mainly to diminished C'2 and C'4.48 Anti-muscle antibodies also occurring in this disease have been reported to fix complement in v i t~o .~~ Thus activation of the complement system might occur as an integral or secondary feature of these diseases and account for the elevated titers of immunoconglutinin in sera from such patients.…”

Section: Circumstantial Evidence For Antibody-mediated Complement Actmentioning

confidence: 99%

Immunoconglutinin in various rheumatic diseases and certain diseases suspected of an autoimmune pathogenesis

Bienenstock

Bloch

1967

Arthritis & Rheumatism

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Precipitating Auto-Antibodies in the Connective Tissue Diseases

Cited by 89 publications

References 27 publications

The Relation of Immunoglobulin Class, Pattern of Antinuclear Antibody, and Complement-Fixing Antibodies to DNA in Sera from Patients with Systemic Lupus Erythematosus*

The Relation of Immunoglobulin Class, Pattern of Antinuclear Antibody, and Complement-Fixing Antibodies to DNA in Sera from Patients with Systemic Lupus Erythematosus*

Antibodies to cellular antigens in Sjögren's syndrome.

Immunoconglutinin in various rheumatic diseases and certain diseases suspected of an autoimmune pathogenesis

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